Chronic sleep deprivation disturbs energy balance modulated by suprachiasmatic nucleus efferents in mice
Abstract Background Epidemiologic researches show that short sleep duration may affect feeding behaviors resulting in higher energy intake and increased risk of obesity, but the further mechanisms that can interpret the causality remain unclear. The circadian rhythm is fine-tuned by the suprachiasma...
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| Language: | English |
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BMC
2024-12-01
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| Series: | BMC Biology |
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| Online Access: | https://doi.org/10.1186/s12915-024-02097-4 |
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| author | Tingting Du Shuailing Liu Honghong Yu Tian Hu Lina Huang Lanyue Gao Lihong Jia Jiajin Hu Yang Yu Qi Sun |
| author_facet | Tingting Du Shuailing Liu Honghong Yu Tian Hu Lina Huang Lanyue Gao Lihong Jia Jiajin Hu Yang Yu Qi Sun |
| author_sort | Tingting Du |
| collection | DOAJ |
| description | Abstract Background Epidemiologic researches show that short sleep duration may affect feeding behaviors resulting in higher energy intake and increased risk of obesity, but the further mechanisms that can interpret the causality remain unclear. The circadian rhythm is fine-tuned by the suprachiasmatic nucleus (SCN) as the master clock, which is essential for driving rhythms in food intake and energy metabolism through neuronal projections to the arcuate nucleus (ARC) and paraventricular nucleus (PVN). Results We showed that chronic SD-induced aberrant expressions of AgRP/NPY and POMC attributed to compromised JAK/STAT3 signals and reduced energy expenditure in the mice, which can be rescued with AAV-genetic overexpression of BMAL1 into SCN. The potential mechanism may be related to the disruptions of SCN efferent mediated by BMAL1. Conclusions Chronic SD impairs energy balance through directly dampening BMAL1 expression, probably in the transcription level, in the SCN, which in turn affects the neuron projections to ARC and PVN. Remarkably, we provide evidence that may explain the causal mechanisms associated with sleep curtailment and obesity in adolescents. Graphical Abstract |
| format | Article |
| id | doaj-art-be92a463385f45dbb0a5b93c3ab24bf5 |
| institution | Kabale University |
| issn | 1741-7007 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Biology |
| spelling | doaj-art-be92a463385f45dbb0a5b93c3ab24bf52024-12-29T12:47:16ZengBMCBMC Biology1741-70072024-12-0122112910.1186/s12915-024-02097-4Chronic sleep deprivation disturbs energy balance modulated by suprachiasmatic nucleus efferents in miceTingting Du0Shuailing Liu1Honghong Yu2Tian Hu3Lina Huang4Lanyue Gao5Lihong Jia6Jiajin Hu7Yang Yu8Qi Sun9Key Laboratory of Environmental Stress and Chronic Disease Control & Prevention Ministry of Education, China Medical UniversityKey Laboratory of Environmental Stress and Chronic Disease Control & Prevention Ministry of Education, China Medical UniversityKey Laboratory of Environmental Stress and Chronic Disease Control & Prevention Ministry of Education, China Medical UniversityKey Laboratory of Environmental Stress and Chronic Disease Control & Prevention Ministry of Education, China Medical UniversityKey Laboratory of Environmental Stress and Chronic Disease Control & Prevention Ministry of Education, China Medical UniversityExperimental Center, China Medical UniversityKey Laboratory of Environmental Stress and Chronic Disease Control & Prevention Ministry of Education, China Medical UniversityInstitute of Health Sciences, China Medical UniversityInstitute of Health Sciences, China Medical UniversityKey Laboratory of Environmental Stress and Chronic Disease Control & Prevention Ministry of Education, China Medical UniversityAbstract Background Epidemiologic researches show that short sleep duration may affect feeding behaviors resulting in higher energy intake and increased risk of obesity, but the further mechanisms that can interpret the causality remain unclear. The circadian rhythm is fine-tuned by the suprachiasmatic nucleus (SCN) as the master clock, which is essential for driving rhythms in food intake and energy metabolism through neuronal projections to the arcuate nucleus (ARC) and paraventricular nucleus (PVN). Results We showed that chronic SD-induced aberrant expressions of AgRP/NPY and POMC attributed to compromised JAK/STAT3 signals and reduced energy expenditure in the mice, which can be rescued with AAV-genetic overexpression of BMAL1 into SCN. The potential mechanism may be related to the disruptions of SCN efferent mediated by BMAL1. Conclusions Chronic SD impairs energy balance through directly dampening BMAL1 expression, probably in the transcription level, in the SCN, which in turn affects the neuron projections to ARC and PVN. Remarkably, we provide evidence that may explain the causal mechanisms associated with sleep curtailment and obesity in adolescents. Graphical Abstracthttps://doi.org/10.1186/s12915-024-02097-4Chronic sleep deprivationSCNFood intakeEnergy expenditureBMAL1 |
| spellingShingle | Tingting Du Shuailing Liu Honghong Yu Tian Hu Lina Huang Lanyue Gao Lihong Jia Jiajin Hu Yang Yu Qi Sun Chronic sleep deprivation disturbs energy balance modulated by suprachiasmatic nucleus efferents in mice BMC Biology Chronic sleep deprivation SCN Food intake Energy expenditure BMAL1 |
| title | Chronic sleep deprivation disturbs energy balance modulated by suprachiasmatic nucleus efferents in mice |
| title_full | Chronic sleep deprivation disturbs energy balance modulated by suprachiasmatic nucleus efferents in mice |
| title_fullStr | Chronic sleep deprivation disturbs energy balance modulated by suprachiasmatic nucleus efferents in mice |
| title_full_unstemmed | Chronic sleep deprivation disturbs energy balance modulated by suprachiasmatic nucleus efferents in mice |
| title_short | Chronic sleep deprivation disturbs energy balance modulated by suprachiasmatic nucleus efferents in mice |
| title_sort | chronic sleep deprivation disturbs energy balance modulated by suprachiasmatic nucleus efferents in mice |
| topic | Chronic sleep deprivation SCN Food intake Energy expenditure BMAL1 |
| url | https://doi.org/10.1186/s12915-024-02097-4 |
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