Is long-bout sedentary behaviour associated with long-term glucose levels 3 months after acute ischaemic stroke? A prospective observational cohort study
Background and purpose Sedentary behaviour is a risk factor for vascular disease and stroke patients are more sedentary than their age-matched peers. The association with glucose levels, as a potential mediator, is unclear, and we have investigated the association between long-bout sedentary behavio...
Saved in:
| Main Authors: | , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMJ Publishing Group
2020-11-01
|
| Series: | BMJ Open |
| Online Access: | https://bmjopen.bmj.com/content/10/11/e037475.full |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1846157470739726336 |
|---|---|
| author | Coralie English Katinka Nordheim Alme Anne-Brita Knapskog Halvor Næss Mala Naik Mona Beyer Hanne Ellekjaer Hege Ihle Hansen Camilla Sollesnes Kummeneje Ragnhild Munthe-Kaas Ingvild Saltvedt Yngve Seljeseth Xiangchung Tan Pernille Thingstad Torunn Askim |
| author_facet | Coralie English Katinka Nordheim Alme Anne-Brita Knapskog Halvor Næss Mala Naik Mona Beyer Hanne Ellekjaer Hege Ihle Hansen Camilla Sollesnes Kummeneje Ragnhild Munthe-Kaas Ingvild Saltvedt Yngve Seljeseth Xiangchung Tan Pernille Thingstad Torunn Askim |
| author_sort | Coralie English |
| collection | DOAJ |
| description | Background and purpose Sedentary behaviour is a risk factor for vascular disease and stroke patients are more sedentary than their age-matched peers. The association with glucose levels, as a potential mediator, is unclear, and we have investigated the association between long-bout sedentary behaviour and long-term glucose levels in stroke survivors.Methods This study uses data from the Norwegian Cognitive Impairment After Stroke study, a multicentre cohort study. The patients were recruited at hospital admission for acute stroke, and the follow-up was done at the outpatient clinic. Sedentary behaviour—being in a sitting or reclining position—was registered 3 months after stroke using position transition data from the body-worn sensor activPAL attached to the unaffected thigh. A MATLAB script was developed to extract activity data from 08:00 to 10:00 for 4 days and to categorise the data into four bout-length categories. The primary outcome was glycated haemoglobin (HbA1c), analysed at 3 months. Regression models were used to analyse the association between HbA1c and sedentary behaviour in the whole population and stratified based on a diagnosis of diabetes mellitus (DM). Age, body mass index and the use of antidiabetic drugs were added as covariates into the models.Results From a total of 815 included patients, 379 patients fulfilled the inclusion criteria for this study. We found no association between time in sedentary behaviour and HbA1c in the whole stroke population. We found time in sedentary behaviour in bouts of ≥90 min to be associated with a higher HbA1c in patients with DM.Conclusion Long-bout sedentary time is associated with a higher HbA1c in patients with DM 3 months after ischaemic stroke. Future research should investigate the benefit of breaking up sedentary time as a secondary preventive measure.Trial registration number NCT02650531, https://clinicaltrials.gov/ct2/show/NCT02650531 |
| format | Article |
| id | doaj-art-be8e499ef6f34e3db91cfbf4d92731ae |
| institution | Kabale University |
| issn | 2044-6055 |
| language | English |
| publishDate | 2020-11-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | BMJ Open |
| spelling | doaj-art-be8e499ef6f34e3db91cfbf4d92731ae2024-11-25T10:15:07ZengBMJ Publishing GroupBMJ Open2044-60552020-11-01101110.1136/bmjopen-2020-037475Is long-bout sedentary behaviour associated with long-term glucose levels 3 months after acute ischaemic stroke? A prospective observational cohort studyCoralie English0Katinka Nordheim Alme1Anne-Brita Knapskog2Halvor Næss3Mala Naik4Mona Beyer5Hanne Ellekjaer6Hege Ihle Hansen7Camilla Sollesnes Kummeneje8Ragnhild Munthe-Kaas9Ingvild Saltvedt10Yngve Seljeseth11Xiangchung Tan12Pernille Thingstad13Torunn Askim14Heart and Stroke Research Program, The University of Newcastle Hunter Medical Research Institute, Newcastle, New South Wales, AustraliaDepartment of Clinical Medicine (K1), University of Bergen, Bergen, NorwayDepartment of Geriatric Medicine, Oslo University Hospital Ullevaal, Oslo, NorwayDepartment of Clinical Medicine (K1), University of Bergen, Bergen, NorwayDepartment of Clinical Science, University of Bergen, Bergen, NorwayInstitute of Clinical Medicine, University of Oslo, Oslo, NorwayDepartment of Neuromedicine and Movement Science, Faculty of Medicine and Health Sciences, NTNU-Norwegian University of Science and Technology, Trondheim, NorwayOslo Stroke Unit, Neurological Department, Oslo University Hospital, Ullevål, Oslo, NorwayDepartment of Neuromedicine and Movement Science, Norwegian University of Science and Technology, Trondheim, NorwayInstitute of Clinical Medicine, University of Oslo, Oslo, NorwayDepartment of Geriatric Medicine, St Olavs Hospital, Trondheim University Hospital, Trondheim, NorwayDepartment of Medicine, Ålesund Hospital, Helse More og Romsdal HF, Ålesund, NorwayDepartment of Neuromedicine and Movement Science, Norwegian University of Science and Technology, Trondheim, NorwayDepartment of Neuromedicine and Movement Science, Norwegian University of Science and Technology, Trondheim, NorwayDepartment of Neuromedicine and Movement Science, Faculty of Medicine and Health Sciences, NTNU-Norwegian University of Science and Technology, Trondheim, NorwayBackground and purpose Sedentary behaviour is a risk factor for vascular disease and stroke patients are more sedentary than their age-matched peers. The association with glucose levels, as a potential mediator, is unclear, and we have investigated the association between long-bout sedentary behaviour and long-term glucose levels in stroke survivors.Methods This study uses data from the Norwegian Cognitive Impairment After Stroke study, a multicentre cohort study. The patients were recruited at hospital admission for acute stroke, and the follow-up was done at the outpatient clinic. Sedentary behaviour—being in a sitting or reclining position—was registered 3 months after stroke using position transition data from the body-worn sensor activPAL attached to the unaffected thigh. A MATLAB script was developed to extract activity data from 08:00 to 10:00 for 4 days and to categorise the data into four bout-length categories. The primary outcome was glycated haemoglobin (HbA1c), analysed at 3 months. Regression models were used to analyse the association between HbA1c and sedentary behaviour in the whole population and stratified based on a diagnosis of diabetes mellitus (DM). Age, body mass index and the use of antidiabetic drugs were added as covariates into the models.Results From a total of 815 included patients, 379 patients fulfilled the inclusion criteria for this study. We found no association between time in sedentary behaviour and HbA1c in the whole stroke population. We found time in sedentary behaviour in bouts of ≥90 min to be associated with a higher HbA1c in patients with DM.Conclusion Long-bout sedentary time is associated with a higher HbA1c in patients with DM 3 months after ischaemic stroke. Future research should investigate the benefit of breaking up sedentary time as a secondary preventive measure.Trial registration number NCT02650531, https://clinicaltrials.gov/ct2/show/NCT02650531https://bmjopen.bmj.com/content/10/11/e037475.full |
| spellingShingle | Coralie English Katinka Nordheim Alme Anne-Brita Knapskog Halvor Næss Mala Naik Mona Beyer Hanne Ellekjaer Hege Ihle Hansen Camilla Sollesnes Kummeneje Ragnhild Munthe-Kaas Ingvild Saltvedt Yngve Seljeseth Xiangchung Tan Pernille Thingstad Torunn Askim Is long-bout sedentary behaviour associated with long-term glucose levels 3 months after acute ischaemic stroke? A prospective observational cohort study BMJ Open |
| title | Is long-bout sedentary behaviour associated with long-term glucose levels 3 months after acute ischaemic stroke? A prospective observational cohort study |
| title_full | Is long-bout sedentary behaviour associated with long-term glucose levels 3 months after acute ischaemic stroke? A prospective observational cohort study |
| title_fullStr | Is long-bout sedentary behaviour associated with long-term glucose levels 3 months after acute ischaemic stroke? A prospective observational cohort study |
| title_full_unstemmed | Is long-bout sedentary behaviour associated with long-term glucose levels 3 months after acute ischaemic stroke? A prospective observational cohort study |
| title_short | Is long-bout sedentary behaviour associated with long-term glucose levels 3 months after acute ischaemic stroke? A prospective observational cohort study |
| title_sort | is long bout sedentary behaviour associated with long term glucose levels 3 months after acute ischaemic stroke a prospective observational cohort study |
| url | https://bmjopen.bmj.com/content/10/11/e037475.full |
| work_keys_str_mv | AT coralieenglish islongboutsedentarybehaviourassociatedwithlongtermglucoselevels3monthsafteracuteischaemicstrokeaprospectiveobservationalcohortstudy AT katinkanordheimalme islongboutsedentarybehaviourassociatedwithlongtermglucoselevels3monthsafteracuteischaemicstrokeaprospectiveobservationalcohortstudy AT annebritaknapskog islongboutsedentarybehaviourassociatedwithlongtermglucoselevels3monthsafteracuteischaemicstrokeaprospectiveobservationalcohortstudy AT halvornæss islongboutsedentarybehaviourassociatedwithlongtermglucoselevels3monthsafteracuteischaemicstrokeaprospectiveobservationalcohortstudy AT malanaik islongboutsedentarybehaviourassociatedwithlongtermglucoselevels3monthsafteracuteischaemicstrokeaprospectiveobservationalcohortstudy AT monabeyer islongboutsedentarybehaviourassociatedwithlongtermglucoselevels3monthsafteracuteischaemicstrokeaprospectiveobservationalcohortstudy AT hanneellekjaer islongboutsedentarybehaviourassociatedwithlongtermglucoselevels3monthsafteracuteischaemicstrokeaprospectiveobservationalcohortstudy AT hegeihlehansen islongboutsedentarybehaviourassociatedwithlongtermglucoselevels3monthsafteracuteischaemicstrokeaprospectiveobservationalcohortstudy AT camillasollesneskummeneje islongboutsedentarybehaviourassociatedwithlongtermglucoselevels3monthsafteracuteischaemicstrokeaprospectiveobservationalcohortstudy AT ragnhildmunthekaas islongboutsedentarybehaviourassociatedwithlongtermglucoselevels3monthsafteracuteischaemicstrokeaprospectiveobservationalcohortstudy AT ingvildsaltvedt islongboutsedentarybehaviourassociatedwithlongtermglucoselevels3monthsafteracuteischaemicstrokeaprospectiveobservationalcohortstudy AT yngveseljeseth islongboutsedentarybehaviourassociatedwithlongtermglucoselevels3monthsafteracuteischaemicstrokeaprospectiveobservationalcohortstudy AT xiangchungtan islongboutsedentarybehaviourassociatedwithlongtermglucoselevels3monthsafteracuteischaemicstrokeaprospectiveobservationalcohortstudy AT pernillethingstad islongboutsedentarybehaviourassociatedwithlongtermglucoselevels3monthsafteracuteischaemicstrokeaprospectiveobservationalcohortstudy AT torunnaskim islongboutsedentarybehaviourassociatedwithlongtermglucoselevels3monthsafteracuteischaemicstrokeaprospectiveobservationalcohortstudy |