The PerioGene North study reveals that periodontal inflammation and advanced jawbone loss in periodontitis associate with serum gingipain antibodies but not with systemic autoimmunity

The PerioGene North study reveals that periodontal inflammation and advanced jawbone loss in periodontitis associate with serum gingipain antibodies but not with systemic autoimmunity

IntroductionPeriodontitis is associated with rheumatoid arthritis (RA). One hypothesis posits that this connection arises from the formation of autoantibodies against citrullinated proteins (ACPA) in inflamed gums, possibly triggered by Porphyromonas gingivalis. We previously demonstrated an increas...

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Bibliographic Details
Main Authors: Elin Kindstedt, Charlotte de Vries, Magnus Wänman, Barbara Aleksandra Potempa, Jan Potempa, Susanne Lindquist, Anders Esberg, Karin Lundberg, Pernilla Lundberg
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-01-01
Series:Frontiers in Immunology
Subjects:
periodontitis
alveolar bone loss
periodontal inflammation
cysteine peptidase gingipain B
anti-citrullinated protein antibodies
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1504975/full
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