Comparison of Inactivated and Oral Poliovirus Vaccines
Introduction: The aim of this study was to compare the rates of systemic and fever reactions of inactivated poliovirus vaccine (IPV) and oral poliovirus vaccine (OPV) at 2, 4, 6 and 18 months of age. Materials and Methods: The study population was made up of 1634 infants at 2, 4, 6, and 18 months o...
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| Language: | English |
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Galenos Publishing House
2013-04-01
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| Series: | Güncel Pediatri |
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| Online Access: | http://dx.doi.org/10.4274/Jcp.11.01 |
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| author | Hüseyin Anıl Korkmaz Adem Aydın Belgin Ünal |
| author_facet | Hüseyin Anıl Korkmaz Adem Aydın Belgin Ünal |
| author_sort | Hüseyin Anıl Korkmaz |
| collection | DOAJ |
| description | Introduction: The aim of this study was to compare the rates of systemic and fever reactions of inactivated poliovirus vaccine (IPV) and oral poliovirus vaccine (OPV) at 2, 4, 6 and 18 months of age.
Materials and Methods: The study population was made up of 1634 infants at 2, 4, 6, and 18 months of age who had received IPV and OPV vaccines between 2003 and 2008. All parents reported systemic and fever adverse events to the investigator.
Results: Systemic and fever reactions were more commonly observed in infants received OPV vaccines than those received IPV vaccines (2.33% vs. 1.12% and 5.2% vs. 2.8%; p<0.05). Infants received IPV vaccines at 2 months of age had higher rates of systemic reactions than those received IPV vaccines at 4, 6 and 18 months of age (1.8%, 0.77%, 0.67% and 0.62%, respectively; p<0.05). Infants who received IPV vaccines at 4 and 6 months of age had higher fever reactions than those received IPV vaccines at 2 and 18 months of age (1.64%, 3.81%, 3.52% and 0.62%, respectively; p<0.05). Similarly, infants who received OPV vaccines at 2 and 4 month of age had higher systemic and fever reactions than those at 6 and 18 months of age (systemic reactions were 15%, 11.11%, 0.77% and 0.17%, respectively; fever reactions were 27.1%, 24.6%, 2.7% and 1.02%, respectively; p<0.001). Irritability and fever were the most frequently reported reactions.
Conclusions: This study showed that IPV had lower rates of adverse events than OPV and emphasized the importance of vaccine adverse event reporting system (Journal of Current Pediatrics 2013; 11: 1-5) |
| format | Article |
| id | doaj-art-be8370c864df4f58b677befd06fb6596 |
| institution | Kabale University |
| issn | 1304-9054 |
| language | English |
| publishDate | 2013-04-01 |
| publisher | Galenos Publishing House |
| record_format | Article |
| series | Güncel Pediatri |
| spelling | doaj-art-be8370c864df4f58b677befd06fb65962025-01-02T20:51:18ZengGalenos Publishing HouseGüncel Pediatri1304-90542013-04-011111510.4274/Jcp.11.01Comparison of Inactivated and Oral Poliovirus VaccinesHüseyin Anıl Korkmaz0Adem Aydın1Belgin Ünal2Dokuz Eylül Üniversitesi Tıp Fakültesi, Çocuk Sağlığı ve Hastalıkları Anabilim Dalı, İzmir, TürkiyeDokuz Eylül Üniversitesi Tıp Fakültesi, Çocuk Sağlığı ve Hastalıkları Anabilim Dalı, Sosyal Pediatri Bilim Dalı, İzmir, TürkiyeDokuz Eylül Üniversitesi Tıp Fakültesi, Halk Sağlığı Anabilim Dalı, İzmir, TürkiyeIntroduction: The aim of this study was to compare the rates of systemic and fever reactions of inactivated poliovirus vaccine (IPV) and oral poliovirus vaccine (OPV) at 2, 4, 6 and 18 months of age. Materials and Methods: The study population was made up of 1634 infants at 2, 4, 6, and 18 months of age who had received IPV and OPV vaccines between 2003 and 2008. All parents reported systemic and fever adverse events to the investigator. Results: Systemic and fever reactions were more commonly observed in infants received OPV vaccines than those received IPV vaccines (2.33% vs. 1.12% and 5.2% vs. 2.8%; p<0.05). Infants received IPV vaccines at 2 months of age had higher rates of systemic reactions than those received IPV vaccines at 4, 6 and 18 months of age (1.8%, 0.77%, 0.67% and 0.62%, respectively; p<0.05). Infants who received IPV vaccines at 4 and 6 months of age had higher fever reactions than those received IPV vaccines at 2 and 18 months of age (1.64%, 3.81%, 3.52% and 0.62%, respectively; p<0.05). Similarly, infants who received OPV vaccines at 2 and 4 month of age had higher systemic and fever reactions than those at 6 and 18 months of age (systemic reactions were 15%, 11.11%, 0.77% and 0.17%, respectively; fever reactions were 27.1%, 24.6%, 2.7% and 1.02%, respectively; p<0.001). Irritability and fever were the most frequently reported reactions. Conclusions: This study showed that IPV had lower rates of adverse events than OPV and emphasized the importance of vaccine adverse event reporting system (Journal of Current Pediatrics 2013; 11: 1-5)http://dx.doi.org/10.4274/Jcp.11.01Inactivated poliovirus vaccineoral poliovirus vaccinevaccinesinfants |
| spellingShingle | Hüseyin Anıl Korkmaz Adem Aydın Belgin Ünal Comparison of Inactivated and Oral Poliovirus Vaccines Güncel Pediatri Inactivated poliovirus vaccine oral poliovirus vaccine vaccines infants |
| title | Comparison of Inactivated and Oral Poliovirus Vaccines |
| title_full | Comparison of Inactivated and Oral Poliovirus Vaccines |
| title_fullStr | Comparison of Inactivated and Oral Poliovirus Vaccines |
| title_full_unstemmed | Comparison of Inactivated and Oral Poliovirus Vaccines |
| title_short | Comparison of Inactivated and Oral Poliovirus Vaccines |
| title_sort | comparison of inactivated and oral poliovirus vaccines |
| topic | Inactivated poliovirus vaccine oral poliovirus vaccine vaccines infants |
| url | http://dx.doi.org/10.4274/Jcp.11.01 |
| work_keys_str_mv | AT huseyinanılkorkmaz comparisonofinactivatedandoralpoliovirusvaccines AT ademaydın comparisonofinactivatedandoralpoliovirusvaccines AT belginunal comparisonofinactivatedandoralpoliovirusvaccines |