Cocoa flavanol supplementation in optimizing post-exercise glycemic control in rats with normoglycemia or diabetes mellitus: findings from the ECODIA study
ABSTRACT Objective: This study investigated the acute effects of cocoa flavanol (CF) supplementation on glucose homeostasis, aerobic performance, and lactate concentration in rats with type 1 diabetes mellitus (T1DM), type 2 diabetes mellitus (T2DM), and normoglycemia (NORM). Materials and methods...
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Brazilian Society of Endocrinology and Metabolism
2024-12-01
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| Series: | Archives of Endocrinology and Metabolism |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S2359-39972024000100381&lng=en&tlng=en |
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| author | Bruno Pereira Melo Joyce Camilla Cruz de Oliveira Aline Cruz Zacarias Letícia Maria de Souza Cordeiro João Gabriel da Silveira Rodrigues Mara Lívia dos Santos Gleide Fernandes de Avelar Romain Meeusen Elsa Heyman Camila Berbert Gomes Pedro Henrique Madureira Ogando Danusa Dias Soares |
| author_facet | Bruno Pereira Melo Joyce Camilla Cruz de Oliveira Aline Cruz Zacarias Letícia Maria de Souza Cordeiro João Gabriel da Silveira Rodrigues Mara Lívia dos Santos Gleide Fernandes de Avelar Romain Meeusen Elsa Heyman Camila Berbert Gomes Pedro Henrique Madureira Ogando Danusa Dias Soares |
| author_sort | Bruno Pereira Melo |
| collection | DOAJ |
| description | ABSTRACT Objective: This study investigated the acute effects of cocoa flavanol (CF) supplementation on glucose homeostasis, aerobic performance, and lactate concentration in rats with type 1 diabetes mellitus (T1DM), type 2 diabetes mellitus (T2DM), and normoglycemia (NORM). Materials and methods: The study included 28 male Wistar rats (220-290 g). Induction of T1DM (n = 8) was achieved through intraperitoneal injection of streptozotocin, while T2DM (n = 10) was induced using an ad libitum high-fat diet combined with a fructose-rich beverage. The rats in the NORM group (n = 10) received a standard diet for 30 days. Two experiments were conducted: (1) T1DM rats performed two successive 30-minute treadmill runs below the anaerobic threshold and (2) T2DM and NORM rats underwent two incremental maximal treadmill running tests, both after CF or placebo supplementation. Blood glucose concentrations were measured from pre-exercise to 60 minutes post-exercise. Results: Glycemic reduction at 60 minutes post-exercise was significantly potentiated by CF compared with placebo supplementation in T1DM, T2DM, and normoglycemic rats (p < 0.05 for all). In T2DM rats, CF induced a glycemic response comparable to the NORM placebo-supplemented condition. These effects of CF persisted despite variations in aerobic performance or lactate concentration after incremental exercise. Conclusion: Supplementation with CF prior to physical exercise elicited a pronounced post-aerobic exercise glycemic reduction. This represents a promising strategy for mitigating the duration of hyperglycemia exposure after physical exercise. |
| format | Article |
| id | doaj-art-be75ab38c4494c1f84d40aa69736a1df |
| institution | Kabale University |
| issn | 2359-4292 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Brazilian Society of Endocrinology and Metabolism |
| record_format | Article |
| series | Archives of Endocrinology and Metabolism |
| spelling | doaj-art-be75ab38c4494c1f84d40aa69736a1df2024-12-17T07:54:44ZengBrazilian Society of Endocrinology and MetabolismArchives of Endocrinology and Metabolism2359-42922024-12-016810.20945/2359-4292-2024-0169Cocoa flavanol supplementation in optimizing post-exercise glycemic control in rats with normoglycemia or diabetes mellitus: findings from the ECODIA studyBruno Pereira Melohttps://orcid.org/0000-0001-9201-8125Joyce Camilla Cruz de Oliveirahttps://orcid.org/0000-0002-6713-9862Aline Cruz Zacariashttps://orcid.org/0000-0002-2574-1775Letícia Maria de Souza Cordeirohttps://orcid.org/0000-0003-2115-2102João Gabriel da Silveira Rodrigueshttps://orcid.org/0000-0003-2646-5079Mara Lívia dos Santoshttps://orcid.org/0009-0005-6880-865XGleide Fernandes de Avelarhttps://orcid.org/0000-0002-2132-3218Romain Meeusenhttps://orcid.org/0000-0001-7553-9957Elsa Heymanhttps://orcid.org/0000-0002-9340-7592Camila Berbert Gomeshttps://orcid.org/0009-0007-6776-2498Pedro Henrique Madureira Ogandohttps://orcid.org/0000-0003-4385-3217Danusa Dias Soareshttps://orcid.org/0000-0002-5705-8890ABSTRACT Objective: This study investigated the acute effects of cocoa flavanol (CF) supplementation on glucose homeostasis, aerobic performance, and lactate concentration in rats with type 1 diabetes mellitus (T1DM), type 2 diabetes mellitus (T2DM), and normoglycemia (NORM). Materials and methods: The study included 28 male Wistar rats (220-290 g). Induction of T1DM (n = 8) was achieved through intraperitoneal injection of streptozotocin, while T2DM (n = 10) was induced using an ad libitum high-fat diet combined with a fructose-rich beverage. The rats in the NORM group (n = 10) received a standard diet for 30 days. Two experiments were conducted: (1) T1DM rats performed two successive 30-minute treadmill runs below the anaerobic threshold and (2) T2DM and NORM rats underwent two incremental maximal treadmill running tests, both after CF or placebo supplementation. Blood glucose concentrations were measured from pre-exercise to 60 minutes post-exercise. Results: Glycemic reduction at 60 minutes post-exercise was significantly potentiated by CF compared with placebo supplementation in T1DM, T2DM, and normoglycemic rats (p < 0.05 for all). In T2DM rats, CF induced a glycemic response comparable to the NORM placebo-supplemented condition. These effects of CF persisted despite variations in aerobic performance or lactate concentration after incremental exercise. Conclusion: Supplementation with CF prior to physical exercise elicited a pronounced post-aerobic exercise glycemic reduction. This represents a promising strategy for mitigating the duration of hyperglycemia exposure after physical exercise.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S2359-39972024000100381&lng=en&tlng=enDiabetespolyphenolsglucosephysical exerciseobesity |
| spellingShingle | Bruno Pereira Melo Joyce Camilla Cruz de Oliveira Aline Cruz Zacarias Letícia Maria de Souza Cordeiro João Gabriel da Silveira Rodrigues Mara Lívia dos Santos Gleide Fernandes de Avelar Romain Meeusen Elsa Heyman Camila Berbert Gomes Pedro Henrique Madureira Ogando Danusa Dias Soares Cocoa flavanol supplementation in optimizing post-exercise glycemic control in rats with normoglycemia or diabetes mellitus: findings from the ECODIA study Archives of Endocrinology and Metabolism Diabetes polyphenols glucose physical exercise obesity |
| title | Cocoa flavanol supplementation in optimizing post-exercise glycemic control in rats with normoglycemia or diabetes mellitus: findings from the ECODIA study |
| title_full | Cocoa flavanol supplementation in optimizing post-exercise glycemic control in rats with normoglycemia or diabetes mellitus: findings from the ECODIA study |
| title_fullStr | Cocoa flavanol supplementation in optimizing post-exercise glycemic control in rats with normoglycemia or diabetes mellitus: findings from the ECODIA study |
| title_full_unstemmed | Cocoa flavanol supplementation in optimizing post-exercise glycemic control in rats with normoglycemia or diabetes mellitus: findings from the ECODIA study |
| title_short | Cocoa flavanol supplementation in optimizing post-exercise glycemic control in rats with normoglycemia or diabetes mellitus: findings from the ECODIA study |
| title_sort | cocoa flavanol supplementation in optimizing post exercise glycemic control in rats with normoglycemia or diabetes mellitus findings from the ecodia study |
| topic | Diabetes polyphenols glucose physical exercise obesity |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S2359-39972024000100381&lng=en&tlng=en |
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