Industrial diet intervention modulates the interplay between gut microbiota and host in semi-stray dogs

Abstract Background The gut microbiota and derived metabolites play a key role in regulating host physiology. Diet is identified as a key regulatory factor of the microbiota composition and, potentially, of subsequent functionalities. Demonstrating the role of diet may be complex as most human studi...

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Main Authors: Soufien Rhimi, Amin Jablaoui, Juan Hernandez, Vincent Mariaule, Nizar Akermi, Tristan Méric, Héla Mkaouar, Magdalena Wysocka, Adam Lesner, Mohamed Ali Borgi, Emmanuelle Maguin, Moez Rhimi
Format: Article
Language:English
Published: BMC 2024-11-01
Series:Animal Microbiome
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Online Access:https://doi.org/10.1186/s42523-024-00357-w
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author Soufien Rhimi
Amin Jablaoui
Juan Hernandez
Vincent Mariaule
Nizar Akermi
Tristan Méric
Héla Mkaouar
Magdalena Wysocka
Adam Lesner
Mohamed Ali Borgi
Emmanuelle Maguin
Moez Rhimi
author_facet Soufien Rhimi
Amin Jablaoui
Juan Hernandez
Vincent Mariaule
Nizar Akermi
Tristan Méric
Héla Mkaouar
Magdalena Wysocka
Adam Lesner
Mohamed Ali Borgi
Emmanuelle Maguin
Moez Rhimi
author_sort Soufien Rhimi
collection DOAJ
description Abstract Background The gut microbiota and derived metabolites play a key role in regulating host physiology. Diet is identified as a key regulatory factor of the microbiota composition and, potentially, of subsequent functionalities. Demonstrating the role of diet may be complex as most human studies are cross-sectional and dietary intervention is often accompanied by hygienic changes. The objective of the present study was to investigate the impact of an industrial diet on the modulation of the microbiota and targeted functionalities using a canine “natural” model. Results We carried out a controlled dietary trial in a cohort of Tunisian semi-stray dogs. We made a transition from a natural diet to an industrial kibble diet and monitored the composition of the fecal microbiota, the concentration of short-chain fatty acids (SCFA) and bile acids (BAs), and protease activities. We demonstrated that dietary change significantly decreased fecal primary bile acids levels and protease activities. Interestingly, correlation analyses demonstrated that variation of specific microbial genera were associated with modulated physiological parameters. Conclusions Our study reveals that an industrial diet induces beneficial changes in microbial composition and functions characterised by increased diversity, synthesis of SCFA and secondary bile acids production, stressing the key role of the diet-microbiota-dog crosstalk.
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spelling doaj-art-be72ecc6ae78400796c3465e48a942952024-11-24T12:44:35ZengBMCAnimal Microbiome2524-46712024-11-016111610.1186/s42523-024-00357-wIndustrial diet intervention modulates the interplay between gut microbiota and host in semi-stray dogsSoufien Rhimi0Amin Jablaoui1Juan Hernandez2Vincent Mariaule3Nizar Akermi4Tristan Méric5Héla Mkaouar6Magdalena Wysocka7Adam Lesner8Mohamed Ali Borgi9Emmanuelle Maguin10Moez Rhimi11Microbiota Interaction with Human and Animal Team (MIHA), Micalis Institute, Institut National de Recherche Pour l’Agriculture, l’Alimentation et l’Environnement, AgroParisTech, Université Paris-SaclayMicrobiota Interaction with Human and Animal Team (MIHA), Micalis Institute, Institut National de Recherche Pour l’Agriculture, l’Alimentation et l’Environnement, AgroParisTech, Université Paris-SaclayMicrobiota Interaction with Human and Animal Team (MIHA), Micalis Institute, Institut National de Recherche Pour l’Agriculture, l’Alimentation et l’Environnement, AgroParisTech, Université Paris-SaclayMicrobiota Interaction with Human and Animal Team (MIHA), Micalis Institute, Institut National de Recherche Pour l’Agriculture, l’Alimentation et l’Environnement, AgroParisTech, Université Paris-SaclayMicrobiota Interaction with Human and Animal Team (MIHA), Micalis Institute, Institut National de Recherche Pour l’Agriculture, l’Alimentation et l’Environnement, AgroParisTech, Université Paris-SaclayMicrobiota Interaction with Human and Animal Team (MIHA), Micalis Institute, Institut National de Recherche Pour l’Agriculture, l’Alimentation et l’Environnement, AgroParisTech, Université Paris-SaclayMicrobiota Interaction with Human and Animal Team (MIHA), Micalis Institute, Institut National de Recherche Pour l’Agriculture, l’Alimentation et l’Environnement, AgroParisTech, Université Paris-SaclayFaculty of Chemistry, University of GdanskFaculty of Chemistry, University of GdanskLaboratory of Biotechnology and Biomonitoring of the Environment and Oasis Ecosystems (LBBEEO), Faculty of Sciences of Gafsa, University of GafsaMicrobiota Interaction with Human and Animal Team (MIHA), Micalis Institute, Institut National de Recherche Pour l’Agriculture, l’Alimentation et l’Environnement, AgroParisTech, Université Paris-SaclayMicrobiota Interaction with Human and Animal Team (MIHA), Micalis Institute, Institut National de Recherche Pour l’Agriculture, l’Alimentation et l’Environnement, AgroParisTech, Université Paris-SaclayAbstract Background The gut microbiota and derived metabolites play a key role in regulating host physiology. Diet is identified as a key regulatory factor of the microbiota composition and, potentially, of subsequent functionalities. Demonstrating the role of diet may be complex as most human studies are cross-sectional and dietary intervention is often accompanied by hygienic changes. The objective of the present study was to investigate the impact of an industrial diet on the modulation of the microbiota and targeted functionalities using a canine “natural” model. Results We carried out a controlled dietary trial in a cohort of Tunisian semi-stray dogs. We made a transition from a natural diet to an industrial kibble diet and monitored the composition of the fecal microbiota, the concentration of short-chain fatty acids (SCFA) and bile acids (BAs), and protease activities. We demonstrated that dietary change significantly decreased fecal primary bile acids levels and protease activities. Interestingly, correlation analyses demonstrated that variation of specific microbial genera were associated with modulated physiological parameters. Conclusions Our study reveals that an industrial diet induces beneficial changes in microbial composition and functions characterised by increased diversity, synthesis of SCFA and secondary bile acids production, stressing the key role of the diet-microbiota-dog crosstalk.https://doi.org/10.1186/s42523-024-00357-wDogDiet interventionSemi-stray dogIndustrial dietGut microbiotaHost response
spellingShingle Soufien Rhimi
Amin Jablaoui
Juan Hernandez
Vincent Mariaule
Nizar Akermi
Tristan Méric
Héla Mkaouar
Magdalena Wysocka
Adam Lesner
Mohamed Ali Borgi
Emmanuelle Maguin
Moez Rhimi
Industrial diet intervention modulates the interplay between gut microbiota and host in semi-stray dogs
Animal Microbiome
Dog
Diet intervention
Semi-stray dog
Industrial diet
Gut microbiota
Host response
title Industrial diet intervention modulates the interplay between gut microbiota and host in semi-stray dogs
title_full Industrial diet intervention modulates the interplay between gut microbiota and host in semi-stray dogs
title_fullStr Industrial diet intervention modulates the interplay between gut microbiota and host in semi-stray dogs
title_full_unstemmed Industrial diet intervention modulates the interplay between gut microbiota and host in semi-stray dogs
title_short Industrial diet intervention modulates the interplay between gut microbiota and host in semi-stray dogs
title_sort industrial diet intervention modulates the interplay between gut microbiota and host in semi stray dogs
topic Dog
Diet intervention
Semi-stray dog
Industrial diet
Gut microbiota
Host response
url https://doi.org/10.1186/s42523-024-00357-w
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