Distinctive function of Tetraspanins: Implication in viral infections
Harboring four transmembrane domains in their structural hallmark, Tetraspanins (Tspans) are a family of glycoproteins with pivotal functions in a variety of biological and cellular processes. Through interacting laterally with each other or specific membrane proteins, Tspans organize tetraspanin-en...
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| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2025-12-01
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| Series: | Virulence |
| Subjects: | |
| Online Access: | https://www.tandfonline.com/doi/10.1080/21505594.2025.2474188 |
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| _version_ | 1849326871030792192 |
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| author | Yuzhi Zhang Chengwei Pan Sijie Wang Yidan Zhou Jiawei Chen Xiaoyu Yu Ruining Peng Nu Zhang Hui Yang |
| author_facet | Yuzhi Zhang Chengwei Pan Sijie Wang Yidan Zhou Jiawei Chen Xiaoyu Yu Ruining Peng Nu Zhang Hui Yang |
| author_sort | Yuzhi Zhang |
| collection | DOAJ |
| description | Harboring four transmembrane domains in their structural hallmark, Tetraspanins (Tspans) are a family of glycoproteins with pivotal functions in a variety of biological and cellular processes. Through interacting laterally with each other or specific membrane proteins, Tspans organize tetraspanin-enriched microdomains (TEMs), modulating cellular signaling, adhesion, fusion, and proliferation. An abundance of evidence has identified the multiple functions in the progression of cancer as well as the underlying molecular mechanisms. Recently, plenty of studies have focused on the utilities of Tspans by pathogens for infection, especially the infection of viruses. The expression of Tspans correlates with the phase of viral infection, the type of virus, and targeted therapies. In particular, perturbations of Tspans in host cells can affect viral attachment, intracellular trafficking, translation, virus assembly, and release. In this review, we summarize and provide a historical overview of the discovery and characterization of various kinds of virus infection and highlight their diversity and complexity, along with the virus life cycle. Furthermore, we examined the current understanding of how various Tspans are involved in the regulatory mechanisms underlying viral infection. This review aims to offer a comprehensive understanding of the targeting of Tspans for therapeutic intervention in infections caused by diverse pathogens. |
| format | Article |
| id | doaj-art-be59d0eb9a504cae938cbc3f1bb43e52 |
| institution | Kabale University |
| issn | 2150-5594 2150-5608 |
| language | English |
| publishDate | 2025-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Virulence |
| spelling | doaj-art-be59d0eb9a504cae938cbc3f1bb43e522025-08-20T03:48:02ZengTaylor & Francis GroupVirulence2150-55942150-56082025-12-0116110.1080/21505594.2025.2474188Distinctive function of Tetraspanins: Implication in viral infectionsYuzhi Zhang0Chengwei Pan1Sijie Wang2Yidan Zhou3Jiawei Chen4Xiaoyu Yu5Ruining Peng6Nu Zhang7Hui Yang8School of Life Sciences, Northwestern Polytechnical University, Xi’an, Shaanxi, ChinaDepartment of Mechanical Engineering, University of Victoria, Victoria, BC, CanadaSchool of Life Sciences, Northwestern Polytechnical University, Xi’an, Shaanxi, ChinaSchool of Life Sciences, Northwestern Polytechnical University, Xi’an, Shaanxi, ChinaSchool of Life Sciences, Northwestern Polytechnical University, Xi’an, Shaanxi, ChinaSchool of Life Sciences, Northwestern Polytechnical University, Xi’an, Shaanxi, ChinaSchool of Life Sciences, Northwestern Polytechnical University, Xi’an, Shaanxi, ChinaSchool of Life Sciences, Northwestern Polytechnical University, Xi’an, Shaanxi, ChinaSchool of Life Sciences, Northwestern Polytechnical University, Xi’an, Shaanxi, ChinaHarboring four transmembrane domains in their structural hallmark, Tetraspanins (Tspans) are a family of glycoproteins with pivotal functions in a variety of biological and cellular processes. Through interacting laterally with each other or specific membrane proteins, Tspans organize tetraspanin-enriched microdomains (TEMs), modulating cellular signaling, adhesion, fusion, and proliferation. An abundance of evidence has identified the multiple functions in the progression of cancer as well as the underlying molecular mechanisms. Recently, plenty of studies have focused on the utilities of Tspans by pathogens for infection, especially the infection of viruses. The expression of Tspans correlates with the phase of viral infection, the type of virus, and targeted therapies. In particular, perturbations of Tspans in host cells can affect viral attachment, intracellular trafficking, translation, virus assembly, and release. In this review, we summarize and provide a historical overview of the discovery and characterization of various kinds of virus infection and highlight their diversity and complexity, along with the virus life cycle. Furthermore, we examined the current understanding of how various Tspans are involved in the regulatory mechanisms underlying viral infection. This review aims to offer a comprehensive understanding of the targeting of Tspans for therapeutic intervention in infections caused by diverse pathogens.https://www.tandfonline.com/doi/10.1080/21505594.2025.2474188Tetraspaninsvirus infectiontargeted therapyregulatory mechanism |
| spellingShingle | Yuzhi Zhang Chengwei Pan Sijie Wang Yidan Zhou Jiawei Chen Xiaoyu Yu Ruining Peng Nu Zhang Hui Yang Distinctive function of Tetraspanins: Implication in viral infections Virulence Tetraspanins virus infection targeted therapy regulatory mechanism |
| title | Distinctive function of Tetraspanins: Implication in viral infections |
| title_full | Distinctive function of Tetraspanins: Implication in viral infections |
| title_fullStr | Distinctive function of Tetraspanins: Implication in viral infections |
| title_full_unstemmed | Distinctive function of Tetraspanins: Implication in viral infections |
| title_short | Distinctive function of Tetraspanins: Implication in viral infections |
| title_sort | distinctive function of tetraspanins implication in viral infections |
| topic | Tetraspanins virus infection targeted therapy regulatory mechanism |
| url | https://www.tandfonline.com/doi/10.1080/21505594.2025.2474188 |
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