A shorter linker in the bispecific antibody RmAb158-scFv8D3 improves TfR-mediated blood-brain barrier transcytosis in vitro

A shorter linker in the bispecific antibody RmAb158-scFv8D3 improves TfR-mediated blood-brain barrier transcytosis in vitro

Abstract Transferrin Receptor (TfR)-mediated transcytosis across the blood-brain barrier (BBB) enables the uptake of bispecific therapeutic antibodies into the brain. At therapeutically relevant concentrations, bivalent binding to TfR appears to reduce the transcytosis efficiency by receptor crossli...

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Bibliographic Details
Main Authors:	Inga Petersen, Jamie I. Morrison, Alex Petrovic, Neira Babic, Nicole G. Metzendorf, Ana Godec, Andrés de la Rosa, Fadi Rofo, Sina Bondza, Jos Buijs, Farahnaz Ranjbarian, Anders Hofer, Dag Sehlin, Greta Hultqvist
Format:	Article
Language:	English
Published:	Nature Portfolio 2024-12-01
Series:	Scientific Reports
Subjects:	Blood-brain-barrier (BBB) shuttle Transferrin receptor (TfR) RmAb158-scFv8D3 Receptor crosslinking Bispecific antibodies Monovalent and bivalent binding
Online Access:	https://doi.org/10.1038/s41598-024-83627-6
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