Molecular Circuits of Resolution in Airway Inflammation
Inflammatory diseases of the lung are common, cause significant morbidity, and can be refractory to therapy. Airway responses to injury, noxious stimuli, or microbes lead to leukocyte recruitment for host defense. As leukocytes respond, they interact with lung resident cells and can elaborate specif...
Saved in:
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2010-01-01
|
| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1100/tsw.2010.143 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1841524416472678400 |
|---|---|
| author | Troy Carlo Bruce D. Levy |
| author_facet | Troy Carlo Bruce D. Levy |
| author_sort | Troy Carlo |
| collection | DOAJ |
| description | Inflammatory diseases of the lung are common, cause significant morbidity, and can be refractory to therapy. Airway responses to injury, noxious stimuli, or microbes lead to leukocyte recruitment for host defense. As leukocytes respond, they interact with lung resident cells and can elaborate specific mediators that are enzymatically generated from polyunsaturated fatty acids via transcellular biosynthesis. These bioactive, lipid-derived, small molecules serve as agonists at specific receptors and are rapidly inactivated in the local environment. This review will focus on the biosynthesis, receptors, cellular responses, and in vivo actions of lipoxins, resolvins, and protectins as exemplary molecular signaling circuits in the airway that are anti-inflammatory and proresolving. |
| format | Article |
| id | doaj-art-be41970d9d5149d5a44b7ecd5a8d0854 |
| institution | Kabale University |
| issn | 1537-744X |
| language | English |
| publishDate | 2010-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-be41970d9d5149d5a44b7ecd5a8d08542025-02-03T05:53:22ZengWileyThe Scientific World Journal1537-744X2010-01-01101386139910.1100/tsw.2010.143Molecular Circuits of Resolution in Airway InflammationTroy Carlo0Bruce D. Levy1Pulmonary and Critical Care Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USAPulmonary and Critical Care Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USAInflammatory diseases of the lung are common, cause significant morbidity, and can be refractory to therapy. Airway responses to injury, noxious stimuli, or microbes lead to leukocyte recruitment for host defense. As leukocytes respond, they interact with lung resident cells and can elaborate specific mediators that are enzymatically generated from polyunsaturated fatty acids via transcellular biosynthesis. These bioactive, lipid-derived, small molecules serve as agonists at specific receptors and are rapidly inactivated in the local environment. This review will focus on the biosynthesis, receptors, cellular responses, and in vivo actions of lipoxins, resolvins, and protectins as exemplary molecular signaling circuits in the airway that are anti-inflammatory and proresolving.http://dx.doi.org/10.1100/tsw.2010.143 |
| spellingShingle | Troy Carlo Bruce D. Levy Molecular Circuits of Resolution in Airway Inflammation The Scientific World Journal |
| title | Molecular Circuits of Resolution in Airway Inflammation |
| title_full | Molecular Circuits of Resolution in Airway Inflammation |
| title_fullStr | Molecular Circuits of Resolution in Airway Inflammation |
| title_full_unstemmed | Molecular Circuits of Resolution in Airway Inflammation |
| title_short | Molecular Circuits of Resolution in Airway Inflammation |
| title_sort | molecular circuits of resolution in airway inflammation |
| url | http://dx.doi.org/10.1100/tsw.2010.143 |
| work_keys_str_mv | AT troycarlo molecularcircuitsofresolutioninairwayinflammation AT brucedlevy molecularcircuitsofresolutioninairwayinflammation |