Effect of maternal diet on gut bacteria and autism spectrum disorder in offspring
Autism spectrum disorder (ASD) is a neurodevelopmental disorder that manifests in early childhood, with its specific causes and pathogenesis remaining incompletely understood. The gut bacteria plays a pivotal role in host health and neurodevelopment. Maternal eating disorders may disrupt maternal gu...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-08-01
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| Series: | Frontiers in Cellular Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fncel.2025.1623576/full |
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| author | Zilin Chen Xu Wang Yuchen Hu Si Zhang Fei Han |
| author_facet | Zilin Chen Xu Wang Yuchen Hu Si Zhang Fei Han |
| author_sort | Zilin Chen |
| collection | DOAJ |
| description | Autism spectrum disorder (ASD) is a neurodevelopmental disorder that manifests in early childhood, with its specific causes and pathogenesis remaining incompletely understood. The gut bacteria plays a pivotal role in host health and neurodevelopment. Maternal eating disorders may disrupt maternal gut bacteria and subsequently influence fetal and neonatal gut bacteria through the gut-placental axis and breastfeeding. This disruption can ultimately impact the microbial-gut-brain axis, the immune system, neurotransmitter dysregulation, and metabolite abnormalities, thereby increasing the risk of ASD in offspring. This paper reviews the adverse effects of bad maternal dietary habits, including high-sugar, high-salt, high-fat diets, alcohol consumption, dietary fiber deficiency, and the intake of ultra-processed foods, on the gut bacteria. It also explores the mechanisms by which gut microbiota disorder may induce ASD through the immune system, neurotransmitters, and metabolites. Additionally, the article proposes potential strategies to prevent ASD by adjusting dietary structures and enhancing gut bacteria health. |
| format | Article |
| id | doaj-art-be3fe227c676432ea62f1cc4afc53e5b |
| institution | Kabale University |
| issn | 1662-5102 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cellular Neuroscience |
| spelling | doaj-art-be3fe227c676432ea62f1cc4afc53e5b2025-08-20T03:59:22ZengFrontiers Media S.A.Frontiers in Cellular Neuroscience1662-51022025-08-011910.3389/fncel.2025.16235761623576Effect of maternal diet on gut bacteria and autism spectrum disorder in offspringZilin Chen0Xu Wang1Yuchen Hu2Si Zhang3Fei Han4Department of Pediatrics, Guang’anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, ChinaState Key Laboratory of Traditional Chinese Medicine Syndrome, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, ChinaDepartment of Pediatrics, Guang’anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, ChinaDepartment of Pediatrics, Guang’anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, ChinaDepartment of Pediatrics, Guang’anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, ChinaAutism spectrum disorder (ASD) is a neurodevelopmental disorder that manifests in early childhood, with its specific causes and pathogenesis remaining incompletely understood. The gut bacteria plays a pivotal role in host health and neurodevelopment. Maternal eating disorders may disrupt maternal gut bacteria and subsequently influence fetal and neonatal gut bacteria through the gut-placental axis and breastfeeding. This disruption can ultimately impact the microbial-gut-brain axis, the immune system, neurotransmitter dysregulation, and metabolite abnormalities, thereby increasing the risk of ASD in offspring. This paper reviews the adverse effects of bad maternal dietary habits, including high-sugar, high-salt, high-fat diets, alcohol consumption, dietary fiber deficiency, and the intake of ultra-processed foods, on the gut bacteria. It also explores the mechanisms by which gut microbiota disorder may induce ASD through the immune system, neurotransmitters, and metabolites. Additionally, the article proposes potential strategies to prevent ASD by adjusting dietary structures and enhancing gut bacteria health.https://www.frontiersin.org/articles/10.3389/fncel.2025.1623576/fullautism spectrum disordergut bacteriaimmune-inflammationmaternal dietmicrobial-gut-brain axis |
| spellingShingle | Zilin Chen Xu Wang Yuchen Hu Si Zhang Fei Han Effect of maternal diet on gut bacteria and autism spectrum disorder in offspring Frontiers in Cellular Neuroscience autism spectrum disorder gut bacteria immune-inflammation maternal diet microbial-gut-brain axis |
| title | Effect of maternal diet on gut bacteria and autism spectrum disorder in offspring |
| title_full | Effect of maternal diet on gut bacteria and autism spectrum disorder in offspring |
| title_fullStr | Effect of maternal diet on gut bacteria and autism spectrum disorder in offspring |
| title_full_unstemmed | Effect of maternal diet on gut bacteria and autism spectrum disorder in offspring |
| title_short | Effect of maternal diet on gut bacteria and autism spectrum disorder in offspring |
| title_sort | effect of maternal diet on gut bacteria and autism spectrum disorder in offspring |
| topic | autism spectrum disorder gut bacteria immune-inflammation maternal diet microbial-gut-brain axis |
| url | https://www.frontiersin.org/articles/10.3389/fncel.2025.1623576/full |
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