Edgetic perturbation models of human inherited disorders

Edgetic perturbation models of human inherited disorders

Abstract Cellular functions are mediated through complex systems of macromolecules and metabolites linked through biochemical and physical interactions, represented in interactome models as ‘nodes’ and ‘edges’, respectively. Better understanding of genotype‐to‐phenotype relationships in human diseas...

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Main Authors: Quan Zhong, Nicolas Simonis, Qian‐Ru Li, Benoit Charloteaux, Fabien Heuze, Niels Klitgord, Stanley Tam, Haiyuan Yu, Kavitha Venkatesan, Danny Mou, Venus Swearingen, Muhammed A Yildirim, Han Yan, Amélie Dricot, David Szeto, Chenwei Lin, Tong Hao, Changyu Fan, Stuart Milstein, Denis Dupuy, Robert Brasseur, David E Hill, Michael E Cusick, Marc Vidal
Format: Article
Language:English
Published: Springer Nature 2009-11-01
Series:Molecular Systems Biology
Subjects:
binary protein interaction
genotype‐to‐phenotype relationships
human Mendelian disorders
network perturbation
Online Access:https://doi.org/10.1038/msb.2009.80
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https://doi.org/10.1038/msb.2009.80

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