The cation channel mechanisms of subthreshold inward depolarizing currents in the mice VTA dopaminergic neurons and their roles in the chronic-stress-induced depression-like behavior

The cation channel mechanisms of subthreshold inward depolarizing currents in the mice VTA dopaminergic neurons and their roles in the chronic-stress-induced depression-like behavior

The slow-intrinsic-pacemaker dopaminergic (DA) neurons originating in the ventral tegmental area (VTA) are implicated in various mood- and emotion-related disorders, such as anxiety, fear, stress and depression. Abnormal activity of projection-specific VTA DA neurons is the key factor in the develop...

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Bibliographic Details
Main Authors: Jing Wang, Min Su, Dongmei Zhang, Ludi Zhang, Chenxu Niu, Chaoyi Li, Shuangzhu You, Yuqi Sang, Yongxue Zhang, Xiaona Du, Hailin Zhang
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2024-12-01
Series:eLife
Subjects:
ventral tegmental area
dopaminergic neurons
cation channels
NALCN
TRPC6 channel
Online Access:https://elifesciences.org/articles/88319
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