Structural basis for the inhibition of coronaviral main proteases by PF-00835231

Structural basis for the inhibition of coronaviral main proteases by PF-00835231

The main protease (M<sup>pro</sup>) of coronaviruses plays a key role in viral replication, thus serving as a hot target for drug design. PF-00835231 is a promising inhibitor of SARS-CoV-2 M<sup>pro</sup>. Here, we r...

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Bibliographic Details
Main Authors: Zhou Xuelan, Lu Xiaolu, Lin Cheng, Zou Xiaofang, Li Wenwen, Zeng Xiangyi, Wang Jie, Zeng Pei, Wang Weiwei, Zhang Jin, Jiang Haihai, Li Jian
Format: Article
Language:English
Published: China Science Publishing & Media Ltd. 2024-07-01
Series:Acta Biochimica et Biophysica Sinica
Subjects:
coronavirus
main protease
PF-00835231
crystal structure
inhibition
Online Access:https://www.sciengine.com/doi/10.3724/abbs.2024122
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