Daikenchuto improves methotrexate-induced chronic small intestinal mucositis by promoting angiogenesis

Daikenchuto improves methotrexate-induced chronic small intestinal mucositis by promoting angiogenesis

AimChronic small-intestinal mucositis (CIM) is a severe gastrointestinal complication that has limited treatment options. This study investigated the potential therapeutic effects of Daikenchuto (DKT), a traditional medicine, on mitigating methotrexate (MTX)-induced CIM in rats.MethodsMale Sprague-D...

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Main Authors: Peilin Li, Yusuke Inoue, Daichi Sadatomi, Sachiko Mogami, Daisuke Miyamoto, Toshiyuki Adachi, Tomohiko Adachi, Akihiko Soyama, Kengo Kanetaka, Weili Gu, Susumu Eguchi
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-08-01
Series:Frontiers in Pharmacology
Subjects:
chemotherapy
methotrexate
intestinal mucositis
daikenchuto
angiogenesis
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1623726/full
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https://www.frontiersin.org/articles/10.3389/fphar.2025.1623726/full

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