Daptomycin in treatment of Gram-positive infections in children with hematological disorders
The study of efficacy and toxicity of daptoycin in treatment of Gram-positive infectons n children with hematological disorders wasperformed. Twelve patients (4 girls and 8 boys) with signs of Gram-positive infections were examined. Staphylococcus aureus wasfound in 66,6% (8 patients), among them in...
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| Format: | Article |
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"Paediatrician" Publishers LLC
2012-05-01
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| Series: | Вопросы современной педиатрии |
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| Online Access: | https://vsp.spr-journal.ru/jour/article/view/485 |
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| author | Z. M. Dyshlevaya A. N. Arkhipova Yu. V. Pashko L. V. Guk E. V. Skorobogatova G. P. Pavlova A. A. Bologov |
| author_facet | Z. M. Dyshlevaya A. N. Arkhipova Yu. V. Pashko L. V. Guk E. V. Skorobogatova G. P. Pavlova A. A. Bologov |
| author_sort | Z. M. Dyshlevaya |
| collection | DOAJ |
| description | The study of efficacy and toxicity of daptoycin in treatment of Gram-positive infectons n children with hematological disorders wasperformed. Twelve patients (4 girls and 8 boys) with signs of Gram-positive infections were examined. Staphylococcus aureus wasfound in 66,6% (8 patients), among them in 3 patients strains were methicillin-resistant; Staphylococcus epidermidis — was found in 16,6% (2 patients); Enterococcus faecalis — in 16,6% (2 patients). By the time of development of infectious complications 7 patients (58,3%) have received antibiotic treatment, in 5 other patients daptomycin was the first-line antibacterial drug. The mean dosage of the drug was 5,8 mg/kg/day. In order to reveal the drug toxicity the monitoring of biochemical serum markers (fibrinogen, ALT, AST, LDG, CPK, creatinine) was performed. The complete resolution of infectious complications occurred in 12,1 ± 4,3 days. The mean duration of daptomycin treatment was 14,2 ± 3,2 days. During the treatment reliable lower of fibrinogen (6,4 ± 1,1 g/l and 3,1 ± 0,9 g/l, р = 0,05) and c-reactive protein (CRP) (12,5 ± 7,1 mg/dL and 3,4 ± 1,8 mg/dL, р = 0,04) was observed. No side effects were observed in all the patients. The performed study allowed to make a conclusion, that daptomycin is an effective and safe drug in treatment of Grampositive infections in children with hematological disorders even with concomitant hypogranulocytosis.Key words: daptomycin, Gram-positive infections, onco-hematology. |
| format | Article |
| id | doaj-art-bda22a72d7fb48b69ceaa7a04a4f1c9c |
| institution | Kabale University |
| issn | 1682-5527 1682-5535 |
| language | English |
| publishDate | 2012-05-01 |
| publisher | "Paediatrician" Publishers LLC |
| record_format | Article |
| series | Вопросы современной педиатрии |
| spelling | doaj-art-bda22a72d7fb48b69ceaa7a04a4f1c9c2025-08-20T03:59:52Zeng"Paediatrician" Publishers LLCВопросы современной педиатрии1682-55271682-55352012-05-01113707410.15690/vsp.v11i3.299485Daptomycin in treatment of Gram-positive infections in children with hematological disordersZ. M. Dyshlevaya0A. N. Arkhipova1Yu. V. Pashko2L. V. Guk3E. V. Skorobogatova4G. P. Pavlova5A. A. Bologov6Russian Children Clinical Hospital of Ministry of Health Care and Social Development, MoscowRussian Children Clinical Hospital of Ministry of Health Care and Social Development, MoscowRussian Children Clinical Hospital of Ministry of Health Care and Social Development, MoscowRussian Children Clinical Hospital of Ministry of Health Care and Social Development, MoscowRussian Children Clinical Hospital of Ministry of Health Care and Social Development, MoscowRussian Children Clinical Hospital of Ministry of Health Care and Social Development, MoscowRussian Children Clinical Hospital of Ministry of Health Care and Social Development, MoscowThe study of efficacy and toxicity of daptoycin in treatment of Gram-positive infectons n children with hematological disorders wasperformed. Twelve patients (4 girls and 8 boys) with signs of Gram-positive infections were examined. Staphylococcus aureus wasfound in 66,6% (8 patients), among them in 3 patients strains were methicillin-resistant; Staphylococcus epidermidis — was found in 16,6% (2 patients); Enterococcus faecalis — in 16,6% (2 patients). By the time of development of infectious complications 7 patients (58,3%) have received antibiotic treatment, in 5 other patients daptomycin was the first-line antibacterial drug. The mean dosage of the drug was 5,8 mg/kg/day. In order to reveal the drug toxicity the monitoring of biochemical serum markers (fibrinogen, ALT, AST, LDG, CPK, creatinine) was performed. The complete resolution of infectious complications occurred in 12,1 ± 4,3 days. The mean duration of daptomycin treatment was 14,2 ± 3,2 days. During the treatment reliable lower of fibrinogen (6,4 ± 1,1 g/l and 3,1 ± 0,9 g/l, р = 0,05) and c-reactive protein (CRP) (12,5 ± 7,1 mg/dL and 3,4 ± 1,8 mg/dL, р = 0,04) was observed. No side effects were observed in all the patients. The performed study allowed to make a conclusion, that daptomycin is an effective and safe drug in treatment of Grampositive infections in children with hematological disorders even with concomitant hypogranulocytosis.Key words: daptomycin, Gram-positive infections, onco-hematology.https://vsp.spr-journal.ru/jour/article/view/485daptomycingram-positive infectionsonco-hematology |
| spellingShingle | Z. M. Dyshlevaya A. N. Arkhipova Yu. V. Pashko L. V. Guk E. V. Skorobogatova G. P. Pavlova A. A. Bologov Daptomycin in treatment of Gram-positive infections in children with hematological disorders Вопросы современной педиатрии daptomycin gram-positive infections onco-hematology |
| title | Daptomycin in treatment of Gram-positive infections in children with hematological disorders |
| title_full | Daptomycin in treatment of Gram-positive infections in children with hematological disorders |
| title_fullStr | Daptomycin in treatment of Gram-positive infections in children with hematological disorders |
| title_full_unstemmed | Daptomycin in treatment of Gram-positive infections in children with hematological disorders |
| title_short | Daptomycin in treatment of Gram-positive infections in children with hematological disorders |
| title_sort | daptomycin in treatment of gram positive infections in children with hematological disorders |
| topic | daptomycin gram-positive infections onco-hematology |
| url | https://vsp.spr-journal.ru/jour/article/view/485 |
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