Royal jelly fermented by honeybee queen (Apis mellifera)-derived Lactobacillus panisapium M1 enhances macrophage phagocytosis through the TLR2/MAPK/SR signaling pathway

Royal jelly fermented by honeybee queen (Apis mellifera)-derived Lactobacillus panisapium M1 enhances macrophage phagocytosis through the TLR2/MAPK/SR signaling pathway

Abstract Background Royal jelly (RJ) has traditionally been used to maintain health, and its fatty acids (10-hydroxy decanoic acid and 10-hydroxy-2-decenoic acid) are reported to have immunomodulatory effects. We recently developed fermented RJ (fRJ) by fermenting RJ with honeybee queen (Apis mellif...

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Main Authors: Shuhei Nonobe, Hideto Okamoto, Takashi Ito, Hayate Itatani, Ayanori Yamaki, Nobuaki Okumura
Format: Article
Language:English
Published: BMC 2025-07-01
Series:BMC Complementary Medicine and Therapies
Subjects:
Royal Jelly (RJ)
Fermented RJ (fRJ)
Macrophage phagocytosis
Lactic acid bacterium
Lactobacillus panisapium M1
Phagocytic receptors
Online Access:https://doi.org/10.1186/s12906-025-04976-x
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