A review of molecular investigations on traditional Chinese medicinal plant-based therapies in multidrug-resistant tuberculosis
Introduction: The escalating threat of drug-resistant tuberculosis (TB) necessitates urgent exploration of alternative treatment methods. Traditional Chinese medicinal (TCM) plants, rich in bioactive phytochemicals, present promising options for addressing this challenge. This review critically exam...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-12-01
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| Series: | Pharmacological Research - Modern Chinese Medicine |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2667142524001635 |
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| author | Robin Raj Arpan Kumar Tripathi P. Saranya Jaskiran kaur Rashmi Saxena Pal Kuldeep Singh Divya Jain MVNL Chaitanya Shivendra Kumar |
| author_facet | Robin Raj Arpan Kumar Tripathi P. Saranya Jaskiran kaur Rashmi Saxena Pal Kuldeep Singh Divya Jain MVNL Chaitanya Shivendra Kumar |
| author_sort | Robin Raj |
| collection | DOAJ |
| description | Introduction: The escalating threat of drug-resistant tuberculosis (TB) necessitates urgent exploration of alternative treatment methods. Traditional Chinese medicinal (TCM) plants, rich in bioactive phytochemicals, present promising options for addressing this challenge. This review critically examines the molecular mechanisms underlying the therapeutic efficacy of phytochemicals derived from selected TCM against drug-resistant TB. Methods: We searched Google Scholar, Scopus, PubMed, and Web of Science, among other search engines, to locate publications about natural compounds that may be utilised to treat multidrug-resistant tuberculosis (MDR TB). Studies from 2007 to 2023 were included, which addressed gaps in our current knowledge of tuberculosis (TB) and the potential of natural compounds. We employed various search terms such as ''Molecular targets and mechanisms,'' ''pathophysiology,'' ''nanotechnology,'' ''natural products,'' ''global statistics and multidrug-resistant TB,'' among others. We selected 108 of the 166 identified papers for evaluation. Only Traditional Chinese Medicinal Plant-Based Treatments for Multidrug-Resistant Tuberculosis were covered. Results: Through an integrative analysis of recent research, we explored the multifaceted interactions between phytochemicals and various molecular targets within Mycobacterium tuberculosis (Mtb). We have highlighted prominent phytochemicals like curcumin from Curcuma longa, resveratrol from Polygonum cuspidatum, and berberine from Berberis spp., elucidating their mechanisms of action and potential synergistic effects with conventional anti-TB drugs. Additionally, we delved into the immunomodulatory properties of phytochemicals, emphasizing their ability to enhance host immune responses against TB infection. Discussion: Innovative approaches such as network pharmacology and molecular docking (mannose receptor targets) are discussed for predicting and validating interactions between phytochemicals and Mtb targets. Moreover, we address challenges related to phytochemical bioavailability, pharmacokinetics, and formulation strategies, proposing methods to enhance their efficacy and clinical translation. Conclusion: In conclusion, this review consolidating existing insights and identifying areas needing further research, this review offers a comprehensive framework for leveraging the therapeutic properties of phytochemicals from traditional medicinal plants, highlighting their potential as supplementary or alternative treatments for drug-resistant TB. |
| format | Article |
| id | doaj-art-bd9976317d394202b3f5ab9b97e6afb5 |
| institution | Kabale University |
| issn | 2667-1425 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Pharmacological Research - Modern Chinese Medicine |
| spelling | doaj-art-bd9976317d394202b3f5ab9b97e6afb52024-12-19T11:02:21ZengElsevierPharmacological Research - Modern Chinese Medicine2667-14252024-12-0113100521A review of molecular investigations on traditional Chinese medicinal plant-based therapies in multidrug-resistant tuberculosisRobin Raj0Arpan Kumar Tripathi1P. Saranya2Jaskiran kaur3Rashmi Saxena Pal4Kuldeep Singh5Divya Jain6MVNL Chaitanya7Shivendra Kumar8School of Pharmaceutical Sciences, Lovely Professional University, Phagwara, Punjab 144402, IndiaFaculty of Pharmaceutical Sciences, Shri Shankaracharya Technical Campus, Bhilai, Chattisgarh, IndiaDepartment of Pharmacy Practice, Saveetha College of Pharmacy, Saveetha Institute of Medical and Technical Sciences SIMATS, Thandalam, Tamil Nadu, IndiaSchool of Pharmaceutical Sciences, Lovely Professional University, Phagwara, Punjab 144402, IndiaSchool of Pharmaceutical Sciences, Lovely Professional University, Phagwara, Punjab 144402, IndiaDepartment of Pharmacology, Institute of Pharmaceutical Research, GLA University Mathura, Uttar Pradesh, IndiaDepartment of Microbiology, School of Applied & Life sciences, Uttaranchal University, Dehradun, Uttarakhand 248007, India; Corresponding authors.School of Pharmaceutical Sciences, Lovely Professional University, Phagwara, Punjab 144402, India; Corresponding authors.Department of Pharmacology, Rajiv Academy for Pharmacy, Mathura, Uttar Pradesh, IndiaIntroduction: The escalating threat of drug-resistant tuberculosis (TB) necessitates urgent exploration of alternative treatment methods. Traditional Chinese medicinal (TCM) plants, rich in bioactive phytochemicals, present promising options for addressing this challenge. This review critically examines the molecular mechanisms underlying the therapeutic efficacy of phytochemicals derived from selected TCM against drug-resistant TB. Methods: We searched Google Scholar, Scopus, PubMed, and Web of Science, among other search engines, to locate publications about natural compounds that may be utilised to treat multidrug-resistant tuberculosis (MDR TB). Studies from 2007 to 2023 were included, which addressed gaps in our current knowledge of tuberculosis (TB) and the potential of natural compounds. We employed various search terms such as ''Molecular targets and mechanisms,'' ''pathophysiology,'' ''nanotechnology,'' ''natural products,'' ''global statistics and multidrug-resistant TB,'' among others. We selected 108 of the 166 identified papers for evaluation. Only Traditional Chinese Medicinal Plant-Based Treatments for Multidrug-Resistant Tuberculosis were covered. Results: Through an integrative analysis of recent research, we explored the multifaceted interactions between phytochemicals and various molecular targets within Mycobacterium tuberculosis (Mtb). We have highlighted prominent phytochemicals like curcumin from Curcuma longa, resveratrol from Polygonum cuspidatum, and berberine from Berberis spp., elucidating their mechanisms of action and potential synergistic effects with conventional anti-TB drugs. Additionally, we delved into the immunomodulatory properties of phytochemicals, emphasizing their ability to enhance host immune responses against TB infection. Discussion: Innovative approaches such as network pharmacology and molecular docking (mannose receptor targets) are discussed for predicting and validating interactions between phytochemicals and Mtb targets. Moreover, we address challenges related to phytochemical bioavailability, pharmacokinetics, and formulation strategies, proposing methods to enhance their efficacy and clinical translation. Conclusion: In conclusion, this review consolidating existing insights and identifying areas needing further research, this review offers a comprehensive framework for leveraging the therapeutic properties of phytochemicals from traditional medicinal plants, highlighting their potential as supplementary or alternative treatments for drug-resistant TB.http://www.sciencedirect.com/science/article/pii/S2667142524001635Traditional Chinese medicinal plantsPhytochemicalsMolecular mechanismsImmunomodulationTuberculosis |
| spellingShingle | Robin Raj Arpan Kumar Tripathi P. Saranya Jaskiran kaur Rashmi Saxena Pal Kuldeep Singh Divya Jain MVNL Chaitanya Shivendra Kumar A review of molecular investigations on traditional Chinese medicinal plant-based therapies in multidrug-resistant tuberculosis Pharmacological Research - Modern Chinese Medicine Traditional Chinese medicinal plants Phytochemicals Molecular mechanisms Immunomodulation Tuberculosis |
| title | A review of molecular investigations on traditional Chinese medicinal plant-based therapies in multidrug-resistant tuberculosis |
| title_full | A review of molecular investigations on traditional Chinese medicinal plant-based therapies in multidrug-resistant tuberculosis |
| title_fullStr | A review of molecular investigations on traditional Chinese medicinal plant-based therapies in multidrug-resistant tuberculosis |
| title_full_unstemmed | A review of molecular investigations on traditional Chinese medicinal plant-based therapies in multidrug-resistant tuberculosis |
| title_short | A review of molecular investigations on traditional Chinese medicinal plant-based therapies in multidrug-resistant tuberculosis |
| title_sort | review of molecular investigations on traditional chinese medicinal plant based therapies in multidrug resistant tuberculosis |
| topic | Traditional Chinese medicinal plants Phytochemicals Molecular mechanisms Immunomodulation Tuberculosis |
| url | http://www.sciencedirect.com/science/article/pii/S2667142524001635 |
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