Serum metabolomic profiling for predicting therapeutic response and toxicity in breast cancer neoadjuvant chemotherapy: a retrospective longitudinal study

Serum metabolomic profiling for predicting therapeutic response and toxicity in breast cancer neoadjuvant chemotherapy: a retrospective longitudinal study

Abstract Background Neoadjuvant chemotherapy (NACT) is the standard-of-care treatment for patients with locally advanced breast cancer (LABC), providing crucial benefits in tumor downstaging. Clinical parameters, such as molecular subtypes, influence the therapeutic impact of NACT. Moreover, severe...

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Bibliographic Details
Main Authors: Zhihao Fang, Guohong Ren, Shouyu Ke, Qimin Xu, Yuhua Chen, Xiaoyuan Shi, Cheng Guo, Jian Huang
Format: Article
Language:English
Published: BMC 2025-01-01
Series:Breast Cancer Research
Subjects:
Breast cancer
Neoadjuvant chemotherapy
Serum
Metabolomics
Acylcarnitine
Essential amino acid
Online Access:https://doi.org/10.1186/s13058-024-01956-w
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