KAT6A chimeras form a self-reinforcing epigenetic module with NURF and MLL/COMPASS to sustain AML

KAT6A chimeras form a self-reinforcing epigenetic module with NURF and MLL/COMPASS to sustain AML

Abstract Background KAT6A-CBP (K/C) and KAT6A-P300 (K/P) fusions are recurrent genetic alterations in acute myeloid leukemia (AML) associated with poor prognosis. Despite their strong oncogenic potential, the mechanisms underlying their genomic targeting and leukemogenic function remain unclear. A m...

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Main Authors: Junhui Lv, Zhinang Yin, Conghui Li, Honglin Wen, Jian Ni, Peiyuan Yang, Zemin Song, Ying Xiang, Honghong Wang, Rui Lu, Li Huang, Ying Zhou, Hai-Bing Zhou, Ruijing Xiao, Pingping Fang, Kaiwei Liang
Format: Article
Language:English
Published: BMC 2025-08-01
Series:Genome Biology
Subjects:
Acute myeloid leukemia
AML
KAT6A
KAT6A-CBP
KAT6A-P300
Nucleosome Remodeling Factor
Online Access:https://doi.org/10.1186/s13059-025-03743-y
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https://doi.org/10.1186/s13059-025-03743-y

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