PIXSIC: A Wireless Intracerebral Radiosensitive Probe in Freely Moving Rats
The aim of this study was to demonstrate the potential of a wireless pixelated β+-sensitive intracerebral probe (PIXSIC) for in vivo positron emission tomographic (PET) radiopharmacology in awake and freely moving rodents. The binding of [ 11 C]raclopride to D 2 dopamine receptors was measured in an...
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| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2015-09-01
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| Series: | Molecular Imaging |
| Online Access: | https://doi.org/10.2310/7290.2015.00020 |
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| _version_ | 1841564124869296128 |
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| author | Laure Balasse Julia Maerk Frédéric Pain Aurelie Genoux Sylvain Fieux Françoise Lefebvre Christian Morel Pascale Gisquet-Verrier Philippe Lanièce Luc Zimmer |
| author_facet | Laure Balasse Julia Maerk Frédéric Pain Aurelie Genoux Sylvain Fieux Françoise Lefebvre Christian Morel Pascale Gisquet-Verrier Philippe Lanièce Luc Zimmer |
| author_sort | Laure Balasse |
| collection | DOAJ |
| description | The aim of this study was to demonstrate the potential of a wireless pixelated β+-sensitive intracerebral probe (PIXSIC) for in vivo positron emission tomographic (PET) radiopharmacology in awake and freely moving rodents. The binding of [ 11 C]raclopride to D 2 dopamine receptors was measured in anesthetized and awake rats following injection of the radiotracer. Competitive binding was assessed with a cold raclopride injection 20 minutes later. The device can accurately monitor binding of PET ligands in freely moving rodents with a high spatiotemporal resolution. Reproducible time-activity curves were obtained for pixels throughout the striatum and cerebellum. A significantly lower [ 11 C]raclopride tracer-specific binding was observed in awake animals. These first results pave the way for PET tracer pharmacokinetics measurements in freely moving rodents. |
| format | Article |
| id | doaj-art-bd605371fd544075b1bf4e9c63bb301e |
| institution | Kabale University |
| issn | 1536-0121 |
| language | English |
| publishDate | 2015-09-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Molecular Imaging |
| spelling | doaj-art-bd605371fd544075b1bf4e9c63bb301e2025-01-02T23:11:32ZengSAGE PublishingMolecular Imaging1536-01212015-09-011410.2310/7290.2015.0002010.2310_7290.2015.00020PIXSIC: A Wireless Intracerebral Radiosensitive Probe in Freely Moving RatsLaure BalasseJulia MaerkFrédéric PainAurelie GenouxSylvain FieuxFrançoise LefebvreChristian MorelPascale Gisquet-VerrierPhilippe LanièceLuc ZimmerThe aim of this study was to demonstrate the potential of a wireless pixelated β+-sensitive intracerebral probe (PIXSIC) for in vivo positron emission tomographic (PET) radiopharmacology in awake and freely moving rodents. The binding of [ 11 C]raclopride to D 2 dopamine receptors was measured in anesthetized and awake rats following injection of the radiotracer. Competitive binding was assessed with a cold raclopride injection 20 minutes later. The device can accurately monitor binding of PET ligands in freely moving rodents with a high spatiotemporal resolution. Reproducible time-activity curves were obtained for pixels throughout the striatum and cerebellum. A significantly lower [ 11 C]raclopride tracer-specific binding was observed in awake animals. These first results pave the way for PET tracer pharmacokinetics measurements in freely moving rodents.https://doi.org/10.2310/7290.2015.00020 |
| spellingShingle | Laure Balasse Julia Maerk Frédéric Pain Aurelie Genoux Sylvain Fieux Françoise Lefebvre Christian Morel Pascale Gisquet-Verrier Philippe Lanièce Luc Zimmer PIXSIC: A Wireless Intracerebral Radiosensitive Probe in Freely Moving Rats Molecular Imaging |
| title | PIXSIC: A Wireless Intracerebral Radiosensitive Probe in Freely Moving Rats |
| title_full | PIXSIC: A Wireless Intracerebral Radiosensitive Probe in Freely Moving Rats |
| title_fullStr | PIXSIC: A Wireless Intracerebral Radiosensitive Probe in Freely Moving Rats |
| title_full_unstemmed | PIXSIC: A Wireless Intracerebral Radiosensitive Probe in Freely Moving Rats |
| title_short | PIXSIC: A Wireless Intracerebral Radiosensitive Probe in Freely Moving Rats |
| title_sort | pixsic a wireless intracerebral radiosensitive probe in freely moving rats |
| url | https://doi.org/10.2310/7290.2015.00020 |
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