New formyl indole derivatives based on thiobarbituric acid and their nano-formulations; synthesis, characterization, parasitology and histopathology investigations

New formyl indole derivatives based on thiobarbituric acid and their nano-formulations; synthesis, characterization, parasitology and histopathology investigations

Abstract New formyl indole derivatives based on thiobarbituric acid were designed for targeting parasitological applications. The new compounds (5-((1H-indol-3-yl)methylene)-2-thioxodihydropyrimidine-4,6(1H,5H)-dione (3a), and 5-((1-benzyl-1H-indol-3-yl)methylene)-2-thioxodihydropyrimidine-4,6(1H,5H...

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Bibliographic Details
Main Authors: Walaa Ali Abdelhalim, Ahmed R. Rabee, Saied M. Soliman, Mohamed Hagar, Esraa A. Moneer, Basant A. Bakr, Assem Barakat, Matti Haukka, Hanaa A. Rasheed
Format: Article
Language:English
Published: Nature Portfolio 2025-01-01
Series:Scientific Reports
Subjects:
Thiobarbituric acid
Aldol condensation
Nano formulation
Parasitology
Histopathology investigation
Online Access:https://doi.org/10.1038/s41598-024-81683-6
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