Case Report: IVCM of corneal chlorpromazine toxicity drug deposits
To investigate corneal deposits in a patient undergoing long-term chlorpromazine therapy using in vivo confocal microscopy with the HRT II Rostock Corneal Module. We reported a 45-year-old woman with a 7-year history of chlorpromazine therapy presented with bilateral photophobia and a 4-year history...
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Frontiers Media S.A.
2025-08-01
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| Series: | Frontiers in Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2025.1614699/full |
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| author | Xianwen Xiao Xianwen Xiao Xianwen Xiao Xianwen Xiao Xianwen Xiao Xianwen Xiao Xie Fang Xie Fang Xie Fang Xie Fang Xie Fang Xie Fang Zhiwen Xie Zhiwen Xie Zhiwen Xie Zhiwen Xie Zhiwen Xie Zhiwen Xie Shunrong Luo Shunrong Luo Shunrong Luo Shunrong Luo Shunrong Luo Shunrong Luo Yuan Lin Yuan Lin Yuan Lin Yuan Lin Yuan Lin Yuan Lin Huping Wu Huping Wu Huping Wu Huping Wu Huping Wu Huping Wu |
| author_facet | Xianwen Xiao Xianwen Xiao Xianwen Xiao Xianwen Xiao Xianwen Xiao Xianwen Xiao Xie Fang Xie Fang Xie Fang Xie Fang Xie Fang Xie Fang Zhiwen Xie Zhiwen Xie Zhiwen Xie Zhiwen Xie Zhiwen Xie Zhiwen Xie Shunrong Luo Shunrong Luo Shunrong Luo Shunrong Luo Shunrong Luo Shunrong Luo Yuan Lin Yuan Lin Yuan Lin Yuan Lin Yuan Lin Yuan Lin Huping Wu Huping Wu Huping Wu Huping Wu Huping Wu Huping Wu |
| author_sort | Xianwen Xiao |
| collection | DOAJ |
| description | To investigate corneal deposits in a patient undergoing long-term chlorpromazine therapy using in vivo confocal microscopy with the HRT II Rostock Corneal Module. We reported a 45-year-old woman with a 7-year history of chlorpromazine therapy presented with bilateral photophobia and a 4-year history of gradual-onset blurred vision. Slit-lamp examination revealed yellowish deposits in the corneal endothelium and Descemet’s membrane. In vivo confocal microscopy identified irregular hyper-reflective deposits in all corneal layers. The epithelial and superficial stromal deposits had well-defined edges, while the posterior stromal, Descemet’s membrane, and endothelial deposits appeared as hollow granules and streaks. This study is the first to use in vivo confocal microscopy to identify crystalline deposits in the corneal stroma and endothelium caused by high-dose chlorpromazine. These findings offer new insights into drug metabolism on the ocular surface and provide a basis for future research. |
| format | Article |
| id | doaj-art-bd5706c74a7d4c8c8d0e5030be13ac17 |
| institution | Kabale University |
| issn | 2296-858X |
| language | English |
| publishDate | 2025-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Medicine |
| spelling | doaj-art-bd5706c74a7d4c8c8d0e5030be13ac172025-08-20T05:33:00ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2025-08-011210.3389/fmed.2025.16146991614699Case Report: IVCM of corneal chlorpromazine toxicity drug depositsXianwen Xiao0Xianwen Xiao1Xianwen Xiao2Xianwen Xiao3Xianwen Xiao4Xianwen Xiao5Xie Fang6Xie Fang7Xie Fang8Xie Fang9Xie Fang10Xie Fang11Zhiwen Xie12Zhiwen Xie13Zhiwen Xie14Zhiwen Xie15Zhiwen Xie16Zhiwen Xie17Shunrong Luo18Shunrong Luo19Shunrong Luo20Shunrong Luo21Shunrong Luo22Shunrong Luo23Yuan Lin24Yuan Lin25Yuan Lin26Yuan Lin27Yuan Lin28Yuan Lin29Huping Wu30Huping Wu31Huping Wu32Huping Wu33Huping Wu34Huping Wu35Xiamen Eye Center and Eye Institute of Xiamen University, School of Medicine, Xiamen, ChinaXiamen Clinical Research Center for Eye Diseases, Xiamen, Fujian, ChinaXiamen Key Laboratory of Ophthalmology, Xiamen, Fujian, ChinaFujian Key Laboratory of Corneal & Ocular Surface Diseases, Xiamen, Fujian, ChinaXiamen Key Laboratory of Corneal & Ocular Surface Diseases, Xiamen, Fujian, ChinaTranslational Medicine Institute of Xiamen Eye Center of Xiamen University, Xiamen, Fujian, ChinaXiamen Eye Center and Eye Institute of Xiamen University, School of Medicine, Xiamen, ChinaXiamen Clinical Research Center for Eye Diseases, Xiamen, Fujian, ChinaXiamen Key Laboratory of Ophthalmology, Xiamen, Fujian, ChinaFujian Key Laboratory of Corneal & Ocular Surface Diseases, Xiamen, Fujian, ChinaXiamen Key Laboratory of Corneal & Ocular Surface Diseases, Xiamen, Fujian, ChinaTranslational Medicine Institute of Xiamen Eye Center of Xiamen University, Xiamen, Fujian, ChinaXiamen Eye Center and Eye Institute of Xiamen University, School of Medicine, Xiamen, ChinaXiamen Clinical Research Center for Eye Diseases, Xiamen, Fujian, ChinaXiamen Key Laboratory of Ophthalmology, Xiamen, Fujian, ChinaFujian Key Laboratory of Corneal & Ocular Surface Diseases, Xiamen, Fujian, ChinaXiamen Key Laboratory of Corneal & Ocular Surface Diseases, Xiamen, Fujian, ChinaTranslational Medicine Institute of Xiamen Eye Center of Xiamen University, Xiamen, Fujian, ChinaXiamen Eye Center and Eye Institute of Xiamen University, School of Medicine, Xiamen, ChinaXiamen Clinical Research Center for Eye Diseases, Xiamen, Fujian, ChinaXiamen Key Laboratory of Ophthalmology, Xiamen, Fujian, ChinaFujian Key Laboratory of Corneal & Ocular Surface Diseases, Xiamen, Fujian, ChinaXiamen Key Laboratory of Corneal & Ocular Surface Diseases, Xiamen, Fujian, ChinaTranslational Medicine Institute of Xiamen Eye Center of Xiamen University, Xiamen, Fujian, ChinaXiamen Eye Center and Eye Institute of Xiamen University, School of Medicine, Xiamen, ChinaXiamen Clinical Research Center for Eye Diseases, Xiamen, Fujian, ChinaXiamen Key Laboratory of Ophthalmology, Xiamen, Fujian, ChinaFujian Key Laboratory of Corneal & Ocular Surface Diseases, Xiamen, Fujian, ChinaXiamen Key Laboratory of Corneal & Ocular Surface Diseases, Xiamen, Fujian, ChinaTranslational Medicine Institute of Xiamen Eye Center of Xiamen University, Xiamen, Fujian, ChinaXiamen Eye Center and Eye Institute of Xiamen University, School of Medicine, Xiamen, ChinaXiamen Clinical Research Center for Eye Diseases, Xiamen, Fujian, ChinaXiamen Key Laboratory of Ophthalmology, Xiamen, Fujian, ChinaFujian Key Laboratory of Corneal & Ocular Surface Diseases, Xiamen, Fujian, ChinaXiamen Key Laboratory of Corneal & Ocular Surface Diseases, Xiamen, Fujian, ChinaTranslational Medicine Institute of Xiamen Eye Center of Xiamen University, Xiamen, Fujian, ChinaTo investigate corneal deposits in a patient undergoing long-term chlorpromazine therapy using in vivo confocal microscopy with the HRT II Rostock Corneal Module. We reported a 45-year-old woman with a 7-year history of chlorpromazine therapy presented with bilateral photophobia and a 4-year history of gradual-onset blurred vision. Slit-lamp examination revealed yellowish deposits in the corneal endothelium and Descemet’s membrane. In vivo confocal microscopy identified irregular hyper-reflective deposits in all corneal layers. The epithelial and superficial stromal deposits had well-defined edges, while the posterior stromal, Descemet’s membrane, and endothelial deposits appeared as hollow granules and streaks. This study is the first to use in vivo confocal microscopy to identify crystalline deposits in the corneal stroma and endothelium caused by high-dose chlorpromazine. These findings offer new insights into drug metabolism on the ocular surface and provide a basis for future research.https://www.frontiersin.org/articles/10.3389/fmed.2025.1614699/fullchlorpromazineocular surfacetoxicitycornealdrug depositsin vivo confocal microscopy |
| spellingShingle | Xianwen Xiao Xianwen Xiao Xianwen Xiao Xianwen Xiao Xianwen Xiao Xianwen Xiao Xie Fang Xie Fang Xie Fang Xie Fang Xie Fang Xie Fang Zhiwen Xie Zhiwen Xie Zhiwen Xie Zhiwen Xie Zhiwen Xie Zhiwen Xie Shunrong Luo Shunrong Luo Shunrong Luo Shunrong Luo Shunrong Luo Shunrong Luo Yuan Lin Yuan Lin Yuan Lin Yuan Lin Yuan Lin Yuan Lin Huping Wu Huping Wu Huping Wu Huping Wu Huping Wu Huping Wu Case Report: IVCM of corneal chlorpromazine toxicity drug deposits Frontiers in Medicine chlorpromazine ocular surface toxicity corneal drug deposits in vivo confocal microscopy |
| title | Case Report: IVCM of corneal chlorpromazine toxicity drug deposits |
| title_full | Case Report: IVCM of corneal chlorpromazine toxicity drug deposits |
| title_fullStr | Case Report: IVCM of corneal chlorpromazine toxicity drug deposits |
| title_full_unstemmed | Case Report: IVCM of corneal chlorpromazine toxicity drug deposits |
| title_short | Case Report: IVCM of corneal chlorpromazine toxicity drug deposits |
| title_sort | case report ivcm of corneal chlorpromazine toxicity drug deposits |
| topic | chlorpromazine ocular surface toxicity corneal drug deposits in vivo confocal microscopy |
| url | https://www.frontiersin.org/articles/10.3389/fmed.2025.1614699/full |
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