Optimized chelator and nanoparticle strategies for high-activity 103Pd-loaded biodegradable brachytherapy seeds
Abstract Background Brachytherapy (BT) is routinely used in the treatment of various cancers. Current BT relies on the placement of large sources of radioactivity at the tumor site, requiring applicators that may cause local traumas and lesions. Further, they suffer from inflexibility in where they...
Saved in:
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
SpringerOpen
2024-12-01
|
| Series: | EJNMMI Radiopharmacy and Chemistry |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s41181-024-00309-4 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1841559026409668608 |
|---|---|
| author | Emanuel Sporer Claire Deville Natan J. W. Straathof Linda M. Bruun Ulli Köster Mikael Jensen Thomas L. Andresen Paul J. Kempen Jonas R. Henriksen Andreas I. Jensen |
| author_facet | Emanuel Sporer Claire Deville Natan J. W. Straathof Linda M. Bruun Ulli Köster Mikael Jensen Thomas L. Andresen Paul J. Kempen Jonas R. Henriksen Andreas I. Jensen |
| author_sort | Emanuel Sporer |
| collection | DOAJ |
| description | Abstract Background Brachytherapy (BT) is routinely used in the treatment of various cancers. Current BT relies on the placement of large sources of radioactivity at the tumor site, requiring applicators that may cause local traumas and lesions. Further, they suffer from inflexibility in where they can be placed and some sources reside permanently in the body, causing potential long-term discomfort. These issues can be circumvented through injectable sources, prepared as biodegradable materials containing radionuclides that form solid seeds after administration. The level of radioactivity contained in such seeds must be sufficient to achieve substantial local irradiation. In this report, we investigate two different strategies for biodegradable BT seeds. Results The first strategy entails injectable seeds based on 103Pd-labeled palladium-gold alloy nanoparticles ([103Pd]PdAuNPs). These were prepared by combining [103Pd]PdH2Cl4 and AuHCl4, followed by lipophilic surface coating and dispersed in lactose octaisobutyrate and ethanol (LOIB:EtOH), in overall radiochemical yield (RCY) of 83%. With the second strategy, [103Pd]Pd-SSIB was prepared by conjugating the [16]aneS4 chelator with lipophilic sucrose septaisobutyrate (SSIB) followed by complexation with [103Pd]PdH2Cl4 (RCY = 99%) and mixed with LOIB:EtOH. [103Pd]Pd-SSIB was likewise formulated as injectable liquid forming seeds by mixing with LOIB. Both formulations reached activities of 1.0–1.5 GBq/mL and negligible release of radioactivity after injection of 100 µL (100–150 MBq) into aqueous buffer or mouse serum of less than 1% over one month. Conclusion Both strategies for forming injectable BT seeds containing high 103Pd activity resulted in high radiolabeling yields, high activity per seed, and high activity retention. We consider both strategies suitable for BT, with the preferable strategy using a [16]aneS4 chelator due to its higher biodegradability. |
| format | Article |
| id | doaj-art-bd4c985ee34d4ef39d82ca03dbd4f02a |
| institution | Kabale University |
| issn | 2365-421X |
| language | English |
| publishDate | 2024-12-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | EJNMMI Radiopharmacy and Chemistry |
| spelling | doaj-art-bd4c985ee34d4ef39d82ca03dbd4f02a2025-01-05T12:50:35ZengSpringerOpenEJNMMI Radiopharmacy and Chemistry2365-421X2024-12-019111810.1186/s41181-024-00309-4Optimized chelator and nanoparticle strategies for high-activity 103Pd-loaded biodegradable brachytherapy seedsEmanuel Sporer0Claire Deville1Natan J. W. Straathof2Linda M. Bruun3Ulli Köster4Mikael Jensen5Thomas L. Andresen6Paul J. Kempen7Jonas R. Henriksen8Andreas I. Jensen9The Hevesy Laboratory, DTU Health TechnologyThe Hevesy Laboratory, DTU Health TechnologyThe Hevesy Laboratory, DTU Health TechnologySection for Cell and Drug Technologies, DTU Health TechnologyInstitut Laue-LangevinThe Hevesy Laboratory, DTU Health TechnologyThe Hevesy Laboratory, DTU Health TechnologyNational Centre for Nano Fabrication and Characterization, DTU NanolabSection for Cell and Drug Technologies, DTU Health TechnologyThe Hevesy Laboratory, DTU Health TechnologyAbstract Background Brachytherapy (BT) is routinely used in the treatment of various cancers. Current BT relies on the placement of large sources of radioactivity at the tumor site, requiring applicators that may cause local traumas and lesions. Further, they suffer from inflexibility in where they can be placed and some sources reside permanently in the body, causing potential long-term discomfort. These issues can be circumvented through injectable sources, prepared as biodegradable materials containing radionuclides that form solid seeds after administration. The level of radioactivity contained in such seeds must be sufficient to achieve substantial local irradiation. In this report, we investigate two different strategies for biodegradable BT seeds. Results The first strategy entails injectable seeds based on 103Pd-labeled palladium-gold alloy nanoparticles ([103Pd]PdAuNPs). These were prepared by combining [103Pd]PdH2Cl4 and AuHCl4, followed by lipophilic surface coating and dispersed in lactose octaisobutyrate and ethanol (LOIB:EtOH), in overall radiochemical yield (RCY) of 83%. With the second strategy, [103Pd]Pd-SSIB was prepared by conjugating the [16]aneS4 chelator with lipophilic sucrose septaisobutyrate (SSIB) followed by complexation with [103Pd]PdH2Cl4 (RCY = 99%) and mixed with LOIB:EtOH. [103Pd]Pd-SSIB was likewise formulated as injectable liquid forming seeds by mixing with LOIB. Both formulations reached activities of 1.0–1.5 GBq/mL and negligible release of radioactivity after injection of 100 µL (100–150 MBq) into aqueous buffer or mouse serum of less than 1% over one month. Conclusion Both strategies for forming injectable BT seeds containing high 103Pd activity resulted in high radiolabeling yields, high activity per seed, and high activity retention. We consider both strategies suitable for BT, with the preferable strategy using a [16]aneS4 chelator due to its higher biodegradability.https://doi.org/10.1186/s41181-024-00309-4BrachytherapyPalladium-103Auger radiotherapyRadiochemistryGold nanoparticlesBiodegradable gels |
| spellingShingle | Emanuel Sporer Claire Deville Natan J. W. Straathof Linda M. Bruun Ulli Köster Mikael Jensen Thomas L. Andresen Paul J. Kempen Jonas R. Henriksen Andreas I. Jensen Optimized chelator and nanoparticle strategies for high-activity 103Pd-loaded biodegradable brachytherapy seeds EJNMMI Radiopharmacy and Chemistry Brachytherapy Palladium-103 Auger radiotherapy Radiochemistry Gold nanoparticles Biodegradable gels |
| title | Optimized chelator and nanoparticle strategies for high-activity 103Pd-loaded biodegradable brachytherapy seeds |
| title_full | Optimized chelator and nanoparticle strategies for high-activity 103Pd-loaded biodegradable brachytherapy seeds |
| title_fullStr | Optimized chelator and nanoparticle strategies for high-activity 103Pd-loaded biodegradable brachytherapy seeds |
| title_full_unstemmed | Optimized chelator and nanoparticle strategies for high-activity 103Pd-loaded biodegradable brachytherapy seeds |
| title_short | Optimized chelator and nanoparticle strategies for high-activity 103Pd-loaded biodegradable brachytherapy seeds |
| title_sort | optimized chelator and nanoparticle strategies for high activity 103pd loaded biodegradable brachytherapy seeds |
| topic | Brachytherapy Palladium-103 Auger radiotherapy Radiochemistry Gold nanoparticles Biodegradable gels |
| url | https://doi.org/10.1186/s41181-024-00309-4 |
| work_keys_str_mv | AT emanuelsporer optimizedchelatorandnanoparticlestrategiesforhighactivity103pdloadedbiodegradablebrachytherapyseeds AT clairedeville optimizedchelatorandnanoparticlestrategiesforhighactivity103pdloadedbiodegradablebrachytherapyseeds AT natanjwstraathof optimizedchelatorandnanoparticlestrategiesforhighactivity103pdloadedbiodegradablebrachytherapyseeds AT lindambruun optimizedchelatorandnanoparticlestrategiesforhighactivity103pdloadedbiodegradablebrachytherapyseeds AT ullikoster optimizedchelatorandnanoparticlestrategiesforhighactivity103pdloadedbiodegradablebrachytherapyseeds AT mikaeljensen optimizedchelatorandnanoparticlestrategiesforhighactivity103pdloadedbiodegradablebrachytherapyseeds AT thomaslandresen optimizedchelatorandnanoparticlestrategiesforhighactivity103pdloadedbiodegradablebrachytherapyseeds AT pauljkempen optimizedchelatorandnanoparticlestrategiesforhighactivity103pdloadedbiodegradablebrachytherapyseeds AT jonasrhenriksen optimizedchelatorandnanoparticlestrategiesforhighactivity103pdloadedbiodegradablebrachytherapyseeds AT andreasijensen optimizedchelatorandnanoparticlestrategiesforhighactivity103pdloadedbiodegradablebrachytherapyseeds |