Addressing the need for genetic cancer risk assessment in Mexico: From establishment of a formal program to delivery innovation and expansion
Purpose: The purpose of this manuscript is to show the process of the establishment and adaptation of an oncogenetics program in Mexico. Methods: The oncogentics program at the Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán was established as a traditional in-person service and...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-01-01
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| Series: | Genetics in Medicine Open |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2949774424010203 |
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| author | Yanin Chávarri-Guerra José Luis Rodríguez-Olivares Alfredo Ramírez-González José Manuel Moreno-Mirón Alex Lagunas-Medina José Carlos Peñafort-Zamora Jazmin Arteaga-Vázquez Gregorio Quintero-Beuló Roberto Sánchez-Reyes Jeffrey N. Weitzel |
| author_facet | Yanin Chávarri-Guerra José Luis Rodríguez-Olivares Alfredo Ramírez-González José Manuel Moreno-Mirón Alex Lagunas-Medina José Carlos Peñafort-Zamora Jazmin Arteaga-Vázquez Gregorio Quintero-Beuló Roberto Sánchez-Reyes Jeffrey N. Weitzel |
| author_sort | Yanin Chávarri-Guerra |
| collection | DOAJ |
| description | Purpose: The purpose of this manuscript is to show the process of the establishment and adaptation of an oncogenetics program in Mexico. Methods: The oncogentics program at the Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán was established as a traditional in-person service and adapted to include telemedicine counseling to expand services to other hospitals and persists as a mixed counseling model with research/commercial genetic testing. Results: A total of 2222 participants were included with a median age of 47 years and 77.6% were women; 64% and 36% were enrolled in person and by phone, respectively; 91.1% had research testing, 4.7% commercial testing, 2% complementary pharma testing, and 2.1% had more than 1 testing. Results disclosure was by phone for 49.6%, in person for 43.3%, and by videocall for 7.1% of the cases. Cascade testing proportion was similar in both groups (88%), and 14.8% probands and 40.8% family members had a positive result for a pathogenic cancer susceptibility gene variant. Conclusion: Our results demonstrated that genetic cancer risk assessment is feasible in limited resources settings and provide evidence that telemedicine is effective and can be used as an alternative in real-world populations. Our model could be adapted and potentially replicated in other institutions and countries that face similar barriers for health care. |
| format | Article |
| id | doaj-art-bd474574b1634dc8a8c0ef1d80f5f056 |
| institution | Kabale University |
| issn | 2949-7744 |
| language | English |
| publishDate | 2024-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Genetics in Medicine Open |
| spelling | doaj-art-bd474574b1634dc8a8c0ef1d80f5f0562024-12-15T06:19:13ZengElsevierGenetics in Medicine Open2949-77442024-01-012101874Addressing the need for genetic cancer risk assessment in Mexico: From establishment of a formal program to delivery innovation and expansionYanin Chávarri-Guerra0José Luis Rodríguez-Olivares1Alfredo Ramírez-González2José Manuel Moreno-Mirón3Alex Lagunas-Medina4José Carlos Peñafort-Zamora5Jazmin Arteaga-Vázquez6Gregorio Quintero-Beuló7Roberto Sánchez-Reyes8Jeffrey N. Weitzel9Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, MexicoInstituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, MexicoMedical Oncology Affairs, AstraZeneca, Mexico CityUniversidad Panamericana, Mexico City, MexicoInstituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, MexicoInstituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, MexicoInstituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, MexicoMedical Oncology Affairs, AstraZeneca, Mexico City; Hospital General de Mexico Dr. Eduardo Liceaga, Mexico City, MexicoUniversidad Panamericana, Mexico City, Mexico; Centro Médico Nacional La Raza, Instituto Mexicano del Seguro Social, Mexico City, MexicoHospital General de Mexico Dr. Eduardo Liceaga, Mexico City, Mexico; Division of Precision Prevention, University of Kansas Comprehensive Cancer Center, Kansas City, Kansas; Correspondence and requests for materials should be addressed to Jeffrey N. Weitzel, The University of Kansas Comprehensive Cancer Center, 4001 Rainbow Blvd, Kansas City, KC 66160.Purpose: The purpose of this manuscript is to show the process of the establishment and adaptation of an oncogenetics program in Mexico. Methods: The oncogentics program at the Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán was established as a traditional in-person service and adapted to include telemedicine counseling to expand services to other hospitals and persists as a mixed counseling model with research/commercial genetic testing. Results: A total of 2222 participants were included with a median age of 47 years and 77.6% were women; 64% and 36% were enrolled in person and by phone, respectively; 91.1% had research testing, 4.7% commercial testing, 2% complementary pharma testing, and 2.1% had more than 1 testing. Results disclosure was by phone for 49.6%, in person for 43.3%, and by videocall for 7.1% of the cases. Cascade testing proportion was similar in both groups (88%), and 14.8% probands and 40.8% family members had a positive result for a pathogenic cancer susceptibility gene variant. Conclusion: Our results demonstrated that genetic cancer risk assessment is feasible in limited resources settings and provide evidence that telemedicine is effective and can be used as an alternative in real-world populations. Our model could be adapted and potentially replicated in other institutions and countries that face similar barriers for health care.http://www.sciencedirect.com/science/article/pii/S2949774424010203Genetic cancer risk assessmentHereditary cancerLatin AmericaLow- and middle-income countriesTelemedicine |
| spellingShingle | Yanin Chávarri-Guerra José Luis Rodríguez-Olivares Alfredo Ramírez-González José Manuel Moreno-Mirón Alex Lagunas-Medina José Carlos Peñafort-Zamora Jazmin Arteaga-Vázquez Gregorio Quintero-Beuló Roberto Sánchez-Reyes Jeffrey N. Weitzel Addressing the need for genetic cancer risk assessment in Mexico: From establishment of a formal program to delivery innovation and expansion Genetics in Medicine Open Genetic cancer risk assessment Hereditary cancer Latin America Low- and middle-income countries Telemedicine |
| title | Addressing the need for genetic cancer risk assessment in Mexico: From establishment of a formal program to delivery innovation and expansion |
| title_full | Addressing the need for genetic cancer risk assessment in Mexico: From establishment of a formal program to delivery innovation and expansion |
| title_fullStr | Addressing the need for genetic cancer risk assessment in Mexico: From establishment of a formal program to delivery innovation and expansion |
| title_full_unstemmed | Addressing the need for genetic cancer risk assessment in Mexico: From establishment of a formal program to delivery innovation and expansion |
| title_short | Addressing the need for genetic cancer risk assessment in Mexico: From establishment of a formal program to delivery innovation and expansion |
| title_sort | addressing the need for genetic cancer risk assessment in mexico from establishment of a formal program to delivery innovation and expansion |
| topic | Genetic cancer risk assessment Hereditary cancer Latin America Low- and middle-income countries Telemedicine |
| url | http://www.sciencedirect.com/science/article/pii/S2949774424010203 |
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