Topical xenogeneic exosome therapy in a dog with toxic epidermal necrolysis
This report describes a positive outcome of topical exosome therapy for toxic epidermal necrolysis (TEN) in a dog. Enrofloxacin was administered subcutaneously one day before and for 7 days after the surgery for urolithiasis. Fourteen days after discontinuing the treatment, the dog was presented to...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Kafkas University, Faculty of Veterinary Medicine
2024-11-01
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| Series: | Kafkas Universitesi Veteriner Fakültesi Dergisi |
| Subjects: | |
| Online Access: | https://vetdergikafkas.org/pdf.php?id=3151 |
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| Summary: | This report describes a positive outcome of topical exosome therapy for toxic epidermal
necrolysis (TEN) in a dog. Enrofloxacin was administered subcutaneously one day
before and for 7 days after the surgery for urolithiasis. Fourteen days after discontinuing
the treatment, the dog was presented to the clinic for disseminated superficial tissue
loss in the dorsal region which is associated with adverse drug reaction based on the
scores for assessment of drug causality for epidermal necrolysis. Bovine-derived cord
blood exosome was applied in the dose of 1 million/kg, twice a day, with intradermal
and spraying routes to multiple points around the wound. The dog was monitored
weekly, and complete recovery was observed 58 days after treatment. This report shows
that topical xenogeneic exosome may be an alternative treatment approach for wound
healing in dogs. |
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| ISSN: | 1309-2251 |