Evaluation of the LFA-REAL clinician-reported outcome (ClinRO) and patient-reported outcome (PRO): data from the Peruvian Almenara Lupus Cohort
Objective The Lupus Foundation of America Rapid Evaluation of Activity in Lupus (LFA-REAL) clinician-reported outcome (ClinRO) and the LFA-REAL patient-reported outcome (PRO) were developed in order to capture manifestations of SLE from the perspective of both the clinician and the patient. The aim...
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BMJ Publishing Group
2020-11-01
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| Series: | Lupus Science and Medicine |
| Online Access: | https://lupus.bmj.com/content/7/1/e000419.full |
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| author | Manuel Francisco Ugarte-Gil Graciela Alarcon Risto Alfredo Perich-Campos Claudia Elera-Fitzcarrald Cristina Reátegui-Sokolova Rocio Violeta Gamboa-Cardenas Victor Román Pimentel-Quiroz Zoila Rodriguez-Bellido Cesar Augusto Pastor-Asurza Anca D Askanase Paola Zeña-Huancas Samira Garcia-Hirsh Luciana Gil Joan Merrill |
| author_facet | Manuel Francisco Ugarte-Gil Graciela Alarcon Risto Alfredo Perich-Campos Claudia Elera-Fitzcarrald Cristina Reátegui-Sokolova Rocio Violeta Gamboa-Cardenas Victor Román Pimentel-Quiroz Zoila Rodriguez-Bellido Cesar Augusto Pastor-Asurza Anca D Askanase Paola Zeña-Huancas Samira Garcia-Hirsh Luciana Gil Joan Merrill |
| author_sort | Manuel Francisco Ugarte-Gil |
| collection | DOAJ |
| description | Objective The Lupus Foundation of America Rapid Evaluation of Activity in Lupus (LFA-REAL) clinician-reported outcome (ClinRO) and the LFA-REAL patient-reported outcome (PRO) were developed in order to capture manifestations of SLE from the perspective of both the clinician and the patient. The aim of this study is to compare the LFA-REAL ClinRO and PRO with other lupus disease activity measures.Methods A cross-sectional analysis of patients from a single-centre cohort was performed using Spearman’s correlation. Disease activity measures included were LFA-REAL ClinRO (range 0–1400), LFA-REAL PRO (range 0–1200), Systemic Lupus Erythematosus Disease Activity Index 2000 (SLEDAI-2K), clinical SLEDAI-2K and Physician Global Assessment (PGA, range 0–100).Results Two hundred and twenty-seven patients with SLE were studied. The mean age was 46.3 (SD: 13.8); 212 (93.4%) were female. The mean (SD) LFA-REAL ClinRO was 25.4 (34.7), LFA-REAL PRO was 241.1 (187.6), PGA was 11.9 (15.4), SLEDAI-2K was 2.3 (3.3) and clinical SLEDAI-2K was 1.6 (2.9). The LFA-REAL ClinRO correlated with PGA (r=0.758, p<0.001), SLEDAI-2K (r=0.608, p<0.001) and clinical SLEDAI-2K (r=0.697, p<0.001); the LFA-REAL PRO correlated modestly with PGA (r=0.160, p=0.016), SLEDAI-2K (r=0.121, p=0.069), clinical SLEDAI-2K (r=0.143, p=0.031) and LFA-REAL ClinRO (r=0.161, p=0.015).Conclusions The LFA-REAL ClinRO and the LFA-REAL PRO had good and weak correlations, respectively, with several physician-based disease activity measures in a cross-sectional study, suggesting their potential usefulness in establishing disease severity. Longitudinal studies will be required to determine their value in monitoring patients with SLE. |
| format | Article |
| id | doaj-art-bcec9c2fff9a4e8e88ac724e40911ff4 |
| institution | Kabale University |
| issn | 2053-8790 |
| language | English |
| publishDate | 2020-11-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | Lupus Science and Medicine |
| spelling | doaj-art-bcec9c2fff9a4e8e88ac724e40911ff42024-11-12T14:50:10ZengBMJ Publishing GroupLupus Science and Medicine2053-87902020-11-017110.1136/lupus-2020-000419Evaluation of the LFA-REAL clinician-reported outcome (ClinRO) and patient-reported outcome (PRO): data from the Peruvian Almenara Lupus CohortManuel Francisco Ugarte-Gil0Graciela Alarcon1Risto Alfredo Perich-Campos2Claudia Elera-Fitzcarrald3Cristina Reátegui-Sokolova4Rocio Violeta Gamboa-Cardenas5Victor Román Pimentel-Quiroz6Zoila Rodriguez-Bellido7Cesar Augusto Pastor-Asurza8Anca D Askanase9Paola Zeña-Huancas10Samira Garcia-Hirsh11Luciana Gil12Joan Merrill13Rheumatology Department, Hospital Guillermo Almenara Irigoyen, EsSalud, Lima, PeruSchool of Medicine, Universidad Peruana Cayetano Heredia, Lima, PeruRheumatology Department, Hospital Nacional Guillermo Almenara Irigoyen, EsSaalud, Lima, PeruGrupo Peruano de Estudio de Enfermedades Autoinmunes Sistémicas, Universidad Cientifica del Sur, Lima, PeruUnidad de Investigación para la Generación y Síntesis de Evidencias en Salud, Universidad San Ignacio de Loyola, Lima, PeruRheumatology Department, Hospital Nacional Guillermo Almenara Irigoyen, EsSaalud, Lima, PeruRheumatology, Hospital Nivel IV Guillermo Almenara Irigoyen, Lima, PeruUniversidad Nacional Mayor de San Marcos, Lima, PeruRheumatology Department, Hospital Nacional Guillermo Almenara Irigoyen, EsSaalud, Lima, PeruRheumatology, Columbia University Irving Medical Center, New York, New York, USARheumatology, Hospital Nacional Guillermo Almenara Irigoyen, EsSalud, Lima, Peru3Hospital Nacional Guillermo Almenara Essalud, Rheumatology, Lima, Peru3Hospital Nacional Guillermo Almenara Essalud, Rheumatology, Lima, Peru1Oklahoma Medical Research Foundation, Oklahoma City, United States of AmericaObjective The Lupus Foundation of America Rapid Evaluation of Activity in Lupus (LFA-REAL) clinician-reported outcome (ClinRO) and the LFA-REAL patient-reported outcome (PRO) were developed in order to capture manifestations of SLE from the perspective of both the clinician and the patient. The aim of this study is to compare the LFA-REAL ClinRO and PRO with other lupus disease activity measures.Methods A cross-sectional analysis of patients from a single-centre cohort was performed using Spearman’s correlation. Disease activity measures included were LFA-REAL ClinRO (range 0–1400), LFA-REAL PRO (range 0–1200), Systemic Lupus Erythematosus Disease Activity Index 2000 (SLEDAI-2K), clinical SLEDAI-2K and Physician Global Assessment (PGA, range 0–100).Results Two hundred and twenty-seven patients with SLE were studied. The mean age was 46.3 (SD: 13.8); 212 (93.4%) were female. The mean (SD) LFA-REAL ClinRO was 25.4 (34.7), LFA-REAL PRO was 241.1 (187.6), PGA was 11.9 (15.4), SLEDAI-2K was 2.3 (3.3) and clinical SLEDAI-2K was 1.6 (2.9). The LFA-REAL ClinRO correlated with PGA (r=0.758, p<0.001), SLEDAI-2K (r=0.608, p<0.001) and clinical SLEDAI-2K (r=0.697, p<0.001); the LFA-REAL PRO correlated modestly with PGA (r=0.160, p=0.016), SLEDAI-2K (r=0.121, p=0.069), clinical SLEDAI-2K (r=0.143, p=0.031) and LFA-REAL ClinRO (r=0.161, p=0.015).Conclusions The LFA-REAL ClinRO and the LFA-REAL PRO had good and weak correlations, respectively, with several physician-based disease activity measures in a cross-sectional study, suggesting their potential usefulness in establishing disease severity. Longitudinal studies will be required to determine their value in monitoring patients with SLE.https://lupus.bmj.com/content/7/1/e000419.full |
| spellingShingle | Manuel Francisco Ugarte-Gil Graciela Alarcon Risto Alfredo Perich-Campos Claudia Elera-Fitzcarrald Cristina Reátegui-Sokolova Rocio Violeta Gamboa-Cardenas Victor Román Pimentel-Quiroz Zoila Rodriguez-Bellido Cesar Augusto Pastor-Asurza Anca D Askanase Paola Zeña-Huancas Samira Garcia-Hirsh Luciana Gil Joan Merrill Evaluation of the LFA-REAL clinician-reported outcome (ClinRO) and patient-reported outcome (PRO): data from the Peruvian Almenara Lupus Cohort Lupus Science and Medicine |
| title | Evaluation of the LFA-REAL clinician-reported outcome (ClinRO) and patient-reported outcome (PRO): data from the Peruvian Almenara Lupus Cohort |
| title_full | Evaluation of the LFA-REAL clinician-reported outcome (ClinRO) and patient-reported outcome (PRO): data from the Peruvian Almenara Lupus Cohort |
| title_fullStr | Evaluation of the LFA-REAL clinician-reported outcome (ClinRO) and patient-reported outcome (PRO): data from the Peruvian Almenara Lupus Cohort |
| title_full_unstemmed | Evaluation of the LFA-REAL clinician-reported outcome (ClinRO) and patient-reported outcome (PRO): data from the Peruvian Almenara Lupus Cohort |
| title_short | Evaluation of the LFA-REAL clinician-reported outcome (ClinRO) and patient-reported outcome (PRO): data from the Peruvian Almenara Lupus Cohort |
| title_sort | evaluation of the lfa real clinician reported outcome clinro and patient reported outcome pro data from the peruvian almenara lupus cohort |
| url | https://lupus.bmj.com/content/7/1/e000419.full |
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