Inhibition of ALKBH5 demethylase of m6A pathway potentiates HIV-1 reactivation from latency

Inhibition of ALKBH5 demethylase of m6A pathway potentiates HIV-1 reactivation from latency

Abstract Background Current latency-reversing agents (LRAs) employed in the “shock-and-kill” strategy primarily focus on relieving epigenetic and transcriptional blocks to reactivate the latent HIV-1. However, their clinical efficacy is limited, partly due to their inability to fully reverse latency...

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Main Authors: Haider Ali, Jakub Wadas, Maryam Bendoumou, Heng-Chang Chen, Paolo Maiuri, Antoine Dutilleul, Simona Selberg, Lorena Nestola, Kamil Lalik, Veronique Avettand-Fenoël, Coca Necsoi, Alessandro Marcello, Esko Kankuri, Mati Karelson, Stéphane De Wit, Krzysztof Pyrc, Alexander O. Pasternak, Carine Van Lint, Anna Kula-Pacurar
Format: Article
Language:English
Published: BMC 2025-04-01
Series:Virology Journal
Subjects:
HIV-1
Latency
Post-transcriptional mechanisms
Epitranscriptomics
m6A
ALKBH5
Online Access:https://doi.org/10.1186/s12985-025-02744-4
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