Improved efficacy of therapeutic HPV DNA vaccine using intramuscular injection with electroporation compared to conventional needle and needle-free jet injector methods

Improved efficacy of therapeutic HPV DNA vaccine using intramuscular injection with electroporation compared to conventional needle and needle-free jet injector methods

Abstract Background We have previously developed a candidate therapeutic HPV DNA vaccine (pBI-11) encoding mycobacteria heat shock protein 70 linked to HPV16/18 E6/E7 proteins for the control of advanced HPV-associated oropharyngeal cancer (NCT05799144). While naked DNA vaccines are readily produced...

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Bibliographic Details
Main Authors: Shiwen Peng, Darrell Fan, Hsin-Fang Tu, Michelle Cheng, Rebecca C. Arend, Kimberly Levinson, Julia Tao, Richard B. S. Roden, Chien-Fu Hung, T.-C. Wu
Format: Article
Language:English
Published: BMC 2024-12-01
Series:Cell & Bioscience
Subjects:
Human papillomavirus
HPV16
HPV18
E6
E7
DNA vaccine
Online Access:https://doi.org/10.1186/s13578-024-01338-x
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