GPR37 Activation Alleviates Bone Cancer Pain via the Inhibition of Osteoclastogenesis and Neuronal Hyperexcitability

GPR37 Activation Alleviates Bone Cancer Pain via the Inhibition of Osteoclastogenesis and Neuronal Hyperexcitability

Abstract Osteolytic bone cancer pain is a primary concern for cancer patients with bone metastasis, and current therapies offer inadequate pain relief. The present study demonstrates that activation of the G protein‐coupled receptor 37 (GPR37) by neuroprotectin D1 (NPD1) or artesunate (ARU) alleviat...

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Bibliographic Details
Main Authors: Kaiyuan Wang, Yongfang Zhang, Ruichen Shu, Limei Yuan, Huifang Tu, Shengran Wang, Bo Ni, Yi‐Fan Zhang, Changyu Jiang, Yuhui Luo, Yiqing Yin
Format: Article
Language:English
Published: Wiley 2025-04-01
Series:Advanced Science
Subjects:
cancer pain, GPR37
neuroimmune modulation
neuroprotectin D1
osteoclastogenesis
Online Access:https://doi.org/10.1002/advs.202417367
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