Inflammasomes in neuroinflammatory and neurodegenerative diseases
Abstract Neuroinflammation and neurodegeneration often result from the aberrant deposition of aggregated host proteins, including amyloid‐β, α‐synuclein, and prions, that can activate inflammasomes. Inflammasomes function as intracellular sensors of both microbial pathogens and foreign as well as ho...
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| Format: | Article |
| Language: | English |
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Springer Nature
2019-04-01
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| Series: | EMBO Molecular Medicine |
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| Online Access: | https://doi.org/10.15252/emmm.201810248 |
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| _version_ | 1849332137677815808 |
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| author | Sofie Voet Sahana Srinivasan Mohamed Lamkanfi Geert van Loo |
| author_facet | Sofie Voet Sahana Srinivasan Mohamed Lamkanfi Geert van Loo |
| author_sort | Sofie Voet |
| collection | DOAJ |
| description | Abstract Neuroinflammation and neurodegeneration often result from the aberrant deposition of aggregated host proteins, including amyloid‐β, α‐synuclein, and prions, that can activate inflammasomes. Inflammasomes function as intracellular sensors of both microbial pathogens and foreign as well as host‐derived danger signals. Upon activation, they induce an innate immune response by secreting the inflammatory cytokines interleukin (IL)‐1β and IL‐18, and additionally by inducing pyroptosis, a lytic cell death mode that releases additional inflammatory mediators. Microglia are the prominent innate immune cells in the brain for inflammasome activation. However, additional CNS‐resident cell types including astrocytes and neurons, as well as infiltrating myeloid cells from the periphery, express and activate inflammasomes. In this review, we will discuss current understanding of the role of inflammasomes in common degenerative diseases of the brain and highlight inflammasome‐targeted strategies that may potentially treat these diseases. |
| format | Article |
| id | doaj-art-bccd4f65bb8748d0804c63bdd1a7a28b |
| institution | Kabale University |
| issn | 1757-4676 1757-4684 |
| language | English |
| publishDate | 2019-04-01 |
| publisher | Springer Nature |
| record_format | Article |
| series | EMBO Molecular Medicine |
| spelling | doaj-art-bccd4f65bb8748d0804c63bdd1a7a28b2025-08-20T03:46:19ZengSpringer NatureEMBO Molecular Medicine1757-46761757-46842019-04-0111611610.15252/emmm.201810248Inflammasomes in neuroinflammatory and neurodegenerative diseasesSofie Voet0Sahana Srinivasan1Mohamed Lamkanfi2Geert van Loo3VIB Center for Inflammation ResearchVIB Center for Inflammation ResearchDepartment of Internal Medicine, Ghent UniversityVIB Center for Inflammation ResearchAbstract Neuroinflammation and neurodegeneration often result from the aberrant deposition of aggregated host proteins, including amyloid‐β, α‐synuclein, and prions, that can activate inflammasomes. Inflammasomes function as intracellular sensors of both microbial pathogens and foreign as well as host‐derived danger signals. Upon activation, they induce an innate immune response by secreting the inflammatory cytokines interleukin (IL)‐1β and IL‐18, and additionally by inducing pyroptosis, a lytic cell death mode that releases additional inflammatory mediators. Microglia are the prominent innate immune cells in the brain for inflammasome activation. However, additional CNS‐resident cell types including astrocytes and neurons, as well as infiltrating myeloid cells from the periphery, express and activate inflammasomes. In this review, we will discuss current understanding of the role of inflammasomes in common degenerative diseases of the brain and highlight inflammasome‐targeted strategies that may potentially treat these diseases.https://doi.org/10.15252/emmm.201810248diseaseinflammasomeinflammationmicroglianeurodegeneration |
| spellingShingle | Sofie Voet Sahana Srinivasan Mohamed Lamkanfi Geert van Loo Inflammasomes in neuroinflammatory and neurodegenerative diseases EMBO Molecular Medicine disease inflammasome inflammation microglia neurodegeneration |
| title | Inflammasomes in neuroinflammatory and neurodegenerative diseases |
| title_full | Inflammasomes in neuroinflammatory and neurodegenerative diseases |
| title_fullStr | Inflammasomes in neuroinflammatory and neurodegenerative diseases |
| title_full_unstemmed | Inflammasomes in neuroinflammatory and neurodegenerative diseases |
| title_short | Inflammasomes in neuroinflammatory and neurodegenerative diseases |
| title_sort | inflammasomes in neuroinflammatory and neurodegenerative diseases |
| topic | disease inflammasome inflammation microglia neurodegeneration |
| url | https://doi.org/10.15252/emmm.201810248 |
| work_keys_str_mv | AT sofievoet inflammasomesinneuroinflammatoryandneurodegenerativediseases AT sahanasrinivasan inflammasomesinneuroinflammatoryandneurodegenerativediseases AT mohamedlamkanfi inflammasomesinneuroinflammatoryandneurodegenerativediseases AT geertvanloo inflammasomesinneuroinflammatoryandneurodegenerativediseases |