Genetic deletion of the sodium phosphate cotransporter NaPi2a ameliorates heart failure in mice

Genetic deletion of the sodium phosphate cotransporter NaPi2a ameliorates heart failure in mice

Abstract Apical membrane sodium transporters in renal proximal tubules, such as sodium-glucose co-transporter 2, are attractive therapeutic targets for the treatment of heart failure (HF). Sodium-phosphate co-transporter 2a (NaPi2a) is predominantly expressed in the apical membrane of proximal tubul...

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Main Authors: Hiroko Yamauchi-Sawada, Tomoharu Ida, Masashi Nakamura, Minato Umehara, Natsuko Okuno-Ozeki, Itaru Nakamura, Yayoi Matoba, Atsushi Minamida, Yasuto Sunahara, Tomohiro Nakata, Kunihiro Nakai, Aya Yagi-Tomita, Noriko Uehara-Watanabe, Noriyuki Yamashita, Yuhei Kirita, Keiichi Tamagaki, Benjamin D. Humphreys, Satoaki Matoba, Tetsuro Kusaba
Format: Article
Language:English
Published: Nature Portfolio 2025-08-01
Series:Scientific Reports
Subjects:
Heart failure
Cardiac hypertrophy
Sodium/phosphate co-transporter
Fibroblast growth factor 23
Online Access:https://doi.org/10.1038/s41598-025-12691-3
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