Multidimensional comparative evaluation of first-line therapies for extensive-stage small cell lung cancer: a systematic review and network meta-analysis of clinical efficacy and safety profiles

Multidimensional comparative evaluation of first-line therapies for extensive-stage small cell lung cancer: a systematic review and network meta-analysis of clinical efficacy and safety profiles

Abstract Background The first-line treatment for extensive-stage small cell lung cancer (ES-SCLC) has evolved from chemotherapy alone to chemoimmunotherapy. However, the improvements in overall survival (OS) and progression-free survival (PFS) have been modest. Therefore, this study employs a compre...

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Bibliographic Details
Main Authors: Ziyao Jiang, Fangrui Zhao, Butuo Li, Junyi He, Huiwen Yang, Yuhan Ji, Bing Zou, Jinming Yu, Linlin Wang
Format: Article
Language:English
Published: BMC 2025-08-01
Series:BMC Cancer
Subjects:
Small cell lung cancer
Extensive-stage
Chemoimmunotherapy
Immune checkpoint inhibitor
Angiogenesis
Network meta-analysis
Online Access:https://doi.org/10.1186/s12885-025-14750-4
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