Synergic action of MicroRNAs and Wnts delivered by motor neuron EVs in promoting AChR clustering

Synergic action of MicroRNAs and Wnts delivered by motor neuron EVs in promoting AChR clustering

Abstract Background The neuromuscular junction (NMJ) establishment occurs through complex communication events between motor neurons and muscle fibers; however, the molecular mechanisms leading to NMJ formation have yet to be fully elucidated. Little is known about the significance of extracellular...

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Main Authors: Rachele Agostini, Paola Ceccaroli, Emanuela Polidori, Manuela Ferracin, Ilaria Pace, Serena Maggio, Andrea Cioccoloni, Michela Battistelli, Giulia Matacchione, Matilde Sbriscia, Fabiola Olivieri, Fabrizia Cesca, Vilberto Stocchi, Michele Guescini
Format: Article
Language:English
Published: BMC 2025-08-01
Series:Cell Communication and Signaling
Subjects:
Neuromuscular junctions
Wnt signalling
Agrin
β-catenin
Acetylcholine receptor
Extracellular vesicles
Online Access:https://doi.org/10.1186/s12964-025-02312-x
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