Metapneumovirus infection in children in modern conditions: clinical and immunological parallels
Aim. The study of metapneumovirus infection clinical and immunological features in children of different ages. Patients and methods. An analysis of 22 patients with mono-metapneumovirus infection is presented. There were 7 (31.8%) children under the age of 1 year, 8 (36.4%) — 1—3 years old, 7 (31.8%...
Saved in:
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | Russian |
| Published: |
LLC "Diagnostics and Vaccines"
2024-03-01
|
| Series: | Детские инфекции (Москва) |
| Subjects: | |
| Online Access: | https://detinf.elpub.ru/jour/article/view/910 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850074501024317440 |
|---|---|
| author | O. P. Popova S. V. Trushakova I. M. Fedorova S. I. Koteleva S. V. Bunin Ju. V. Shvetsova R. V. Vartyanyan I. G. Lyubeznova |
| author_facet | O. P. Popova S. V. Trushakova I. M. Fedorova S. I. Koteleva S. V. Bunin Ju. V. Shvetsova R. V. Vartyanyan I. G. Lyubeznova |
| author_sort | O. P. Popova |
| collection | DOAJ |
| description | Aim. The study of metapneumovirus infection clinical and immunological features in children of different ages. Patients and methods. An analysis of 22 patients with mono-metapneumovirus infection is presented. There were 7 (31.8%) children under the age of 1 year, 8 (36.4%) — 1—3 years old, 7 (31.8%) — 4—7 years old. Diagnosis of metapneumovirus infection was based on clinical data and on PCR analysis of nasopharyngeal mucus. Immunological studies in 10 patients included immunophenotype of patient's blood lymphocytes and analysis of the interferon system. Results. Among children under the age of 1 year 71.4 ± 17.1% were diagnosed with obstructive bronchitis and 28.6 ± 17.1% had pneumonia. In patients aged 1—3 years pneumonia was observed more often (55.6 ± 17.6%), obstructive bronchitis — less often (33.3 ± 16.7%), and in 11.1 ± 11.1% bronchitis occurred without symptoms of bronchial obstruction. In children aged 4—7 years only the upper respiratory tract was affected in 14.3 ± 13.2% of cases, 57.1 ± 18.7% developed bronchitis and 28.6 ± 17.1% — pneumonia. The immune system state was characterized by a low content of T-helpers (CD3 + CD4 + ) and NK-cells (CD3-CD16 + CD56 + ) detected in 7 (70%) and 5 (50%) patients respectively. IFNγ production was reduced in 70% of children and IFNα in 80%. Conclusion. Metapneumovirus infection in children in modern conditions is characterized by the frequent development of inflammatory changes in the bronchopulmonary system in the early stages of the disease. The disease severity was due to both manifestations of respiratory failure and severe symptoms of intoxication. Immunological studies revealed changes in the cellular link and the interferon system in all age groups. |
| format | Article |
| id | doaj-art-bc8d4da20bb541d5bd3aa0da95701983 |
| institution | DOAJ |
| issn | 2072-8107 |
| language | Russian |
| publishDate | 2024-03-01 |
| publisher | LLC "Diagnostics and Vaccines" |
| record_format | Article |
| series | Детские инфекции (Москва) |
| spelling | doaj-art-bc8d4da20bb541d5bd3aa0da957019832025-08-20T02:46:33ZrusLLC "Diagnostics and Vaccines"Детские инфекции (Москва)2072-81072024-03-01231121710.22627/2072-8107-2024-23-1-12-17646Metapneumovirus infection in children in modern conditions: clinical and immunological parallelsO. P. Popova0S. V. Trushakova1I. M. Fedorova2S. I. Koteleva3S. V. Bunin4Ju. V. Shvetsova5R. V. Vartyanyan6I. G. Lyubeznova7Russian medical Academy of continuous postgraduate education; G.N. Gabrichevsky Moscow Scientific Research Institute of Epidemiology and MicrobiologyN. F. Gamaleya Federal Research Center for Epidemiology & MicrobiologyG.N. Gabrichevsky Moscow Scientific Research Institute of Epidemiology and MicrobiologyG.N. Gabrichevsky Moscow Scientific Research Institute of Epidemiology and MicrobiologyInfectious Clinical Hospital No 1, Moscow Department of HealthcareInfectious Clinical Hospital No 1, Moscow Department of HealthcareN. F. Gamaleya Federal Research Center for Epidemiology & MicrobiologyG.N. Speransky Children's Hospital No 9, Moscow Department of HealthcareAim. The study of metapneumovirus infection clinical and immunological features in children of different ages. Patients and methods. An analysis of 22 patients with mono-metapneumovirus infection is presented. There were 7 (31.8%) children under the age of 1 year, 8 (36.4%) — 1—3 years old, 7 (31.8%) — 4—7 years old. Diagnosis of metapneumovirus infection was based on clinical data and on PCR analysis of nasopharyngeal mucus. Immunological studies in 10 patients included immunophenotype of patient's blood lymphocytes and analysis of the interferon system. Results. Among children under the age of 1 year 71.4 ± 17.1% were diagnosed with obstructive bronchitis and 28.6 ± 17.1% had pneumonia. In patients aged 1—3 years pneumonia was observed more often (55.6 ± 17.6%), obstructive bronchitis — less often (33.3 ± 16.7%), and in 11.1 ± 11.1% bronchitis occurred without symptoms of bronchial obstruction. In children aged 4—7 years only the upper respiratory tract was affected in 14.3 ± 13.2% of cases, 57.1 ± 18.7% developed bronchitis and 28.6 ± 17.1% — pneumonia. The immune system state was characterized by a low content of T-helpers (CD3 + CD4 + ) and NK-cells (CD3-CD16 + CD56 + ) detected in 7 (70%) and 5 (50%) patients respectively. IFNγ production was reduced in 70% of children and IFNα in 80%. Conclusion. Metapneumovirus infection in children in modern conditions is characterized by the frequent development of inflammatory changes in the bronchopulmonary system in the early stages of the disease. The disease severity was due to both manifestations of respiratory failure and severe symptoms of intoxication. Immunological studies revealed changes in the cellular link and the interferon system in all age groups.https://detinf.elpub.ru/jour/article/view/910metapneumovirus infectioncoughbronchitispneumoniarespiratory failureinterferons |
| spellingShingle | O. P. Popova S. V. Trushakova I. M. Fedorova S. I. Koteleva S. V. Bunin Ju. V. Shvetsova R. V. Vartyanyan I. G. Lyubeznova Metapneumovirus infection in children in modern conditions: clinical and immunological parallels Детские инфекции (Москва) metapneumovirus infection cough bronchitis pneumonia respiratory failure interferons |
| title | Metapneumovirus infection in children in modern conditions: clinical and immunological parallels |
| title_full | Metapneumovirus infection in children in modern conditions: clinical and immunological parallels |
| title_fullStr | Metapneumovirus infection in children in modern conditions: clinical and immunological parallels |
| title_full_unstemmed | Metapneumovirus infection in children in modern conditions: clinical and immunological parallels |
| title_short | Metapneumovirus infection in children in modern conditions: clinical and immunological parallels |
| title_sort | metapneumovirus infection in children in modern conditions clinical and immunological parallels |
| topic | metapneumovirus infection cough bronchitis pneumonia respiratory failure interferons |
| url | https://detinf.elpub.ru/jour/article/view/910 |
| work_keys_str_mv | AT oppopova metapneumovirusinfectioninchildreninmodernconditionsclinicalandimmunologicalparallels AT svtrushakova metapneumovirusinfectioninchildreninmodernconditionsclinicalandimmunologicalparallels AT imfedorova metapneumovirusinfectioninchildreninmodernconditionsclinicalandimmunologicalparallels AT sikoteleva metapneumovirusinfectioninchildreninmodernconditionsclinicalandimmunologicalparallels AT svbunin metapneumovirusinfectioninchildreninmodernconditionsclinicalandimmunologicalparallels AT juvshvetsova metapneumovirusinfectioninchildreninmodernconditionsclinicalandimmunologicalparallels AT rvvartyanyan metapneumovirusinfectioninchildreninmodernconditionsclinicalandimmunologicalparallels AT iglyubeznova metapneumovirusinfectioninchildreninmodernconditionsclinicalandimmunologicalparallels |