The cancer-associated fibroblasts interact with malignant T cells in mycosis fungoides and promote the disease progression

The cancer-associated fibroblasts interact with malignant T cells in mycosis fungoides and promote the disease progression

BackgroundCutaneous T-cell lymphoma (CTCL) is a heterogeneous group of T-cell lymphomas characterized with the presence of clonal malignant T cells. Mycosis fungoides (MF) is the most common type of CTCL. However, the pathogenesis of MF and the role of the tumor microenvironment (TME) remain unclear...

Full description

Saved in:

Bibliographic Details
Main Authors:	Yige Zhao, Yong Li, Panpan Wang, Mengyan Zhu, Jiaqi Wang, Bo Xie, Chenyu Tang, Yangyang Ma, Shiwen Wang, Sha Jin, Jinhui Xu, Zhao Li, Xiaoyan Zhang, Liuyu Li, Xiuzu Song, Ping Wang
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2025-02-01
Series:	Frontiers in Immunology
Subjects:	mycosis fungoides (MF) cutaneous T cell lymphoma (CTCL) tissue resident memory T cell (TRM) cancer-associated fibroblast (CAF) tumor microenvironment SOX4
Online Access:	https://www.frontiersin.org/articles/10.3389/fimmu.2024.1474564/full
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

Application of immunohistochemical markers in mycosis fungoides
by: SHAO Kaixin, et al.
Published: (2025-01-01)

Kasr-Al-Ainy cutaneous lymphoma unit protocol for management of mycosis fungoides
by: Randa Youssef, et al.
Published: (2024-01-01)

Insights into treatment of patients with mycosis fungoides or Sézary syndrome using mogamulizumab
by: Francine Foss, et al.
Published: (2025-12-01)

A Case Series of Diagnostic Challenges in Mycosis Fungoides in Resource-poor Settings: Blood Film Examination – A Useful Tool
by: Erere Otrofanowei, et al.
Published: (2024-12-01)

Hypopigmented mycosis fungoides: an important differential diagnosis of hypochromias in childhood
by: Maria Fernanda de Almeida Cavalcante Aranha, et al.
Published: (2025-01-01)

The Progression of Mycosis Fungoides During Treatment with Mogamulizumab: A BIO-MUSE Case Study of the Tumor and Immune Response in Peripheral Blood and Tissue
by: Angelica Johansson, et al.
Published: (2025-01-01)

Dermoscopy of Early-Stage Mycosis Fungoides: Comparative Study with Inflammatory Dermatoses
by: Amel Chabbouh, et al.
Published: (2025-01-01)

Chlormethine Gel for Treatment of Patients with Mycosis Fungoides: Best Practices and Guidance to Clinicians
by: Larisa Geskin, et al.
Published: (2024-11-01)

Cutaneous manifestations associated with unknown HIV infection: a case report
by: Paolo Iacovelli, et al.
Published: (2025-01-01)

Impact of coronavirus disease 2019 on the prognosis of mucor mycosis in diabetic patients in Egypt: a comparative multicenter study
by: Mahmoud ElSamkary, et al.
Published: (2025-01-01)

Liver metastases of colorectal cancer contain different subsets of tissue-resident memory CD8 T cells correlated with a distinct risk of relapse following surgery
by: Syrine Abdeljaoued, et al.
Published: (2025-12-01)

Evaluating biomarkers in canine cytotoxic interface dermatitis reactions to account for clinical and histopathological similarities and differences
by: Shriya Kannan, et al.
Published: (2025-01-01)

Tissue‐resident memory T cells in diseases and therapeutic strategies
by: Daoyuan Xie, et al.
Published: (2025-01-01)

Mycosis Fungoides Involving the Dorsal Tongue
by: Ashley E. Brown, et al.
Published: (2018-01-01)

Single-cell profiling transcriptomic reveals cellular heterogeneity and cellular crosstalk in breast cancer lymphatic node, bone, and brain metastases
by: Longyu Zhu, et al.
Published: (2025-01-01)

Utilizing sc-linker to integrate single-cell RNA sequencing and human genetics to identify cell types and driver genes associated with non-small cell lung cancer
by: Yangfan Zhou, et al.
Published: (2025-01-01)

Response to Hydralazine-Valproate in a Patient with Mycosis Fungoides
by: Alfonso Dueñas-Gonzalez, et al.
Published: (2010-01-01)

Childhood Hypopigmented Mycosis Fungoides: A Rare Diagnosis
by: Cláudia Patraquim, et al.
Published: (2016-01-01)

Human neural rosettes secrete bioactive extracellular vesicles enriched in neuronal and glial cellular components
by: Malena Herrera Lopez, et al.
Published: (2025-01-01)

HDAC10 and its implications in Sézary syndrome pathogenesis
by: Monika Pieniawska, et al.
Published: (2025-01-01)

SOX7 is involved in polyphyllin D-induced G0/G1 cell cycle arrest through down-regulation of cyclin D1
by: Zheng Bin, et al.
Published: (2020-06-01)

Mature tertiary lymphoid structure associated CD103+ CD8+ Trm cells determined improved anti-tumor immune in breast cancer
by: Qin Fang, et al.
Published: (2025-01-01)

Hypopigmented Mycosis Fungoides in an 11-Year-Old Palestinian Boy
by: Duha Rabi, et al.
Published: (2023-01-01)

A Case of Histiocytic Sarcoma Arising from Mycosis Fungoides
by: Ethan A. Burns, et al.
Published: (2019-01-01)

Suggested Guidelines for the Treatment of Mycosis Fungoides in Countries with Limited Resources
by: Mona Abdel-Halim Ibrahim, et al.
Published: (2023-01-01)

PUVA Induced Bullous Pemphigoid in a Patient with Mycosis Fungoides
by: Birgül Özkesici, et al.
Published: (2017-01-01)

Editorial: Impact of the innate and adaptive immune system in driving type 1 inflammatory skin disease
by: Mark Mellett, et al.
Published: (2025-02-01)

TGF-β signaling orchestrates cancer-associated fibroblasts in the tumor microenvironment of human hepatocellular carcinoma: unveiling insights and clinical significance
by: Junwei Ge, et al.
Published: (2025-01-01)

Tumors in the setting of dupilumab use: A review of the literature
by: Shumeng Guo, et al.
Published: (2025-01-01)

Voriconazole Pharmacokinetics Administered at 4 mg/kg IM and IV in Nursehound Sharks (<i>Scyliorhinus stellaris</i>) Under Human Care
by: Daniela Cañizares-Cooz, et al.
Published: (2025-01-01)

Comparative Evaluation of Coronally Advanced Flap and Vestibular Incision Sub-Periosteal Tunnel Access Technique with Platelet-Rich Fibrin in the Treatment of Gingival Recession Defects- A Clinical Study
by: Nidhi Yadav, et al.
Published: (2024-12-01)

Research on Fire Suppression Characteristics of Compressed Air Foams in Full-Scale 220 kV Converter Transformer
by: Yike Guo, et al.
Published: (2024-12-01)

SL$_{4}(\textbf{Z})$ is not purely matricial field
by: Magee, Michael, et al.
Published: (2024-10-01)

A Case of Superficial Mycoses in a Patient with Systemic Lupus Erythematosus
by: Li Z, et al.
Published: (2025-01-01)

Cutaneous granulomas preceding peripheral cutaneous T-cell lymphoma NOS: A call for ongoing surveillance for late-onset malignancy
by: Selin Kolsuz, et al.
Published: (2024-12-01)

Interstitial Mycosis Fungoides: An Unusual Mimic of Interstitial Granuloma Annulare Not to Miss
by: Neha Singh, et al.
Published: (2022-01-01)

COMMON SELF-EVALUATION FRAMEWORK (CAF) FOR THE EDUCATION SYSTEM
by: Alexandra IANCU
Published: (2024-05-01)

Pembrolizumab for the Treatment of Locally Advanced Cutaneous Squamous Cell Carcinoma: Patient Selection and Special Considerations
by: Stewart M, et al.
Published: (2025-02-01)

Flow Cytometric Analysis of T, B, and NK Cells Antigens in Patients with Mycosis Fungoides
by: Serkan Yazıcı, et al.
Published: (2015-01-01)

Hypopigmented Mycosis Fungoides in Type V Skin: A Report of 5 Cases
by: Ranthilaka R. Ranawaka, et al.
Published: (2011-01-01)