Neutrophil to albumin ratio predicts cardiovascular and all cause mortality in CVD patients with abnormal glucose metabolism

Neutrophil to albumin ratio predicts cardiovascular and all cause mortality in CVD patients with abnormal glucose metabolism

Abstract This study examined the relationship between the neutrophil-to-albumin ratio (NPAR) and both all-cause and cardiovascular mortality in U.S. patients with cardiovascular disease (CVD) and abnormal glucose metabolism, using NHANES data from 1999 to 2018. Restricted cubic spline analysis ident...

Full description

Saved in:
Bibliographic Details
Main Authors: Jiaxin Li, Mingyue Yang, Xue Zhang, Rui Huang, Ying Zhang, Kuanlu Fan
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
Subjects:
Neutrophil-percentage-to-albumin ratio
NHANES
Mortality
Cardiovascular
Mediation analysis
Online Access:https://doi.org/10.1038/s41598-025-08130-y
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Abstract This study examined the relationship between the neutrophil-to-albumin ratio (NPAR) and both all-cause and cardiovascular mortality in U.S. patients with cardiovascular disease (CVD) and abnormal glucose metabolism, using NHANES data from 1999 to 2018. Restricted cubic spline analysis identified a significant nonlinear association between NPAR and mortality (p < 0.001). Cox regression results showed that patients in the highest NPAR group (T3, ≥ 15.8) had higher risks of all-cause (HR 1.75, 95% CI 1.50–2.04) and cardiovascular mortality (HR 2.03, 95% CI 1.53–2.68) compared to the lowest group (T1, < 13.5), both with p < 0.0001. Kaplan–Meier survival curves confirmed greater mortality in the T3 group. Mediation analysis found that renal function, measured by eGFR, accounted for 14.49% of the effect on all-cause mortality and 13.38% on cardiovascular mortality. Among the 3163 participants, 1342 experienced all-cause deaths and 462 cardiovascular deaths. This study demonstrated a significant correlation of high NPAR and increased mortality in patients with abnormal glucose metabolism and CVD, suggesting that NPAR may represent a reliable predictor of mortality risk in this population, and emphasizing the importance of both inflammation and renal function monitoring.
ISSN:2045-2322

Similar Items