Trikafta Rescues F508del‐CFTR by Tightening Specific Phosphorylation‐Dependent Interdomain Interactions
ABSTRACT Trikafta effectively corrects the thermal and gating defects associated with the F508del mutation, the most common cause of cystic fibrosis (CF), even at physiological temperatures. However, the exact correction pathway is still unclear. Here, noncovalent interactions among two transmembran...
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| Format: | Article |
| Language: | English |
| Published: |
Wiley-VCH
2025-07-01
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| Series: | Natural Sciences |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/ntls.70009 |
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