Association between the systemic immunity-inflammation index and stroke: a population-based study from NHANES (2015–2020)
Abstract Background The systemic immunity-inflammation index(SII) is a new indicator of composite inflammatory response. Inflammatory response is an important pathological process in stroke. Therefore, this study sought to investigate the association between SII and stroke. Methods We collected data...
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Nature Portfolio
2025-01-01
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| Online Access: | https://doi.org/10.1038/s41598-024-83073-4 |
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| author | Rui Shi Ye Tian Junbiao Tian Qiming Liu Jiayun Zhang Zhe Zhang Yaping Sun Zhanwei Xie |
| author_facet | Rui Shi Ye Tian Junbiao Tian Qiming Liu Jiayun Zhang Zhe Zhang Yaping Sun Zhanwei Xie |
| author_sort | Rui Shi |
| collection | DOAJ |
| description | Abstract Background The systemic immunity-inflammation index(SII) is a new indicator of composite inflammatory response. Inflammatory response is an important pathological process in stroke. Therefore, this study sought to investigate the association between SII and stroke. Methods We collected data on participants with SII and stroke from the 2015–2020 cycle of National Health and Nutrition Examination Survey (NHANES) for the cross-sectional investigation. Multivariate linear regression models were used to test the association between SII and stroke. Fitted smoothing curves and threshold effect analysis were applied to describe the nonlinear relationship. Results A total of 13,287 participants were included in our study, including 611 (4.598%) participants with stroke. In a multivariate linear regression analysis, we found a significant positive association between SII and stroke, and the odds ratio (OR) [95% CI] of SII associating with prevalence of stroke was [1.02 (1.01, 1.04)] (P < 0.01). In subgroup analysis and interaction experiments, we found that this positive relationship was not significantly correlated among different population settings such as age, gender, race, education level, smoking status, high blood pressure, diabetes and coronary heart disease (P for trend > 0.05). Moreover, we found an nonlinear relationship between SII and stroke with an inflection point of 740 (1,000 cells /µl) by using a two-segment linear regression model. Conclusions This study implies that increased SII levels are linked to stroke. To confirm our findings, more large-scale prospective investigations are needed. |
| format | Article |
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| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-01-01 |
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| spelling | doaj-art-bc6b78968571450e9aeef43f01beb9032025-01-05T12:18:46ZengNature PortfolioScientific Reports2045-23222025-01-0115111210.1038/s41598-024-83073-4Association between the systemic immunity-inflammation index and stroke: a population-based study from NHANES (2015–2020)Rui Shi0Ye Tian1Junbiao Tian2Qiming Liu3Jiayun Zhang4Zhe Zhang5Yaping Sun6Zhanwei Xie7Graduate School of Hebei University of Chinese MedicineDepartment of Neurology, The Second Hospital of Hebei Medical UniversityGraduate School of Hebei University of Chinese MedicineGraduate School of Hebei University of Chinese MedicineGraduate School of Hebei University of Chinese MedicineGraduate School of Hebei University of Chinese MedicineDepartment of Traditional Chinese Medicine, Hebei General HospitalDepartment of Geriatrics, The Third Hospital of ShijiazhuangAbstract Background The systemic immunity-inflammation index(SII) is a new indicator of composite inflammatory response. Inflammatory response is an important pathological process in stroke. Therefore, this study sought to investigate the association between SII and stroke. Methods We collected data on participants with SII and stroke from the 2015–2020 cycle of National Health and Nutrition Examination Survey (NHANES) for the cross-sectional investigation. Multivariate linear regression models were used to test the association between SII and stroke. Fitted smoothing curves and threshold effect analysis were applied to describe the nonlinear relationship. Results A total of 13,287 participants were included in our study, including 611 (4.598%) participants with stroke. In a multivariate linear regression analysis, we found a significant positive association between SII and stroke, and the odds ratio (OR) [95% CI] of SII associating with prevalence of stroke was [1.02 (1.01, 1.04)] (P < 0.01). In subgroup analysis and interaction experiments, we found that this positive relationship was not significantly correlated among different population settings such as age, gender, race, education level, smoking status, high blood pressure, diabetes and coronary heart disease (P for trend > 0.05). Moreover, we found an nonlinear relationship between SII and stroke with an inflection point of 740 (1,000 cells /µl) by using a two-segment linear regression model. Conclusions This study implies that increased SII levels are linked to stroke. To confirm our findings, more large-scale prospective investigations are needed.https://doi.org/10.1038/s41598-024-83073-4Systemic immunity-inflammation indexStrokeInflammatory responseCross-sectional studyNHANES |
| spellingShingle | Rui Shi Ye Tian Junbiao Tian Qiming Liu Jiayun Zhang Zhe Zhang Yaping Sun Zhanwei Xie Association between the systemic immunity-inflammation index and stroke: a population-based study from NHANES (2015–2020) Scientific Reports Systemic immunity-inflammation index Stroke Inflammatory response Cross-sectional study NHANES |
| title | Association between the systemic immunity-inflammation index and stroke: a population-based study from NHANES (2015–2020) |
| title_full | Association between the systemic immunity-inflammation index and stroke: a population-based study from NHANES (2015–2020) |
| title_fullStr | Association between the systemic immunity-inflammation index and stroke: a population-based study from NHANES (2015–2020) |
| title_full_unstemmed | Association between the systemic immunity-inflammation index and stroke: a population-based study from NHANES (2015–2020) |
| title_short | Association between the systemic immunity-inflammation index and stroke: a population-based study from NHANES (2015–2020) |
| title_sort | association between the systemic immunity inflammation index and stroke a population based study from nhanes 2015 2020 |
| topic | Systemic immunity-inflammation index Stroke Inflammatory response Cross-sectional study NHANES |
| url | https://doi.org/10.1038/s41598-024-83073-4 |
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