Marine Lectins and Lectin-like Proteins as Promising Molecules Targeting Aberrant Glycosylation Signatures in Human Brain Tumors
Glycosylation is a ubiquitous and the most structurally diverse post-translational modification of proteins. High levels of phenotypic heterogeneity in brain tumors affect the biosynthetic pathway of glycosylation machinery, resulting in aberrant glycosylation patterns. Traditionally, unique glycoco...
Saved in:
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2024-11-01
|
| Series: | Marine Drugs |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1660-3397/22/12/527 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1846103814362365952 |
|---|---|
| author | Ivan Buriak Vadim Kumeiko |
| author_facet | Ivan Buriak Vadim Kumeiko |
| author_sort | Ivan Buriak |
| collection | DOAJ |
| description | Glycosylation is a ubiquitous and the most structurally diverse post-translational modification of proteins. High levels of phenotypic heterogeneity in brain tumors affect the biosynthetic pathway of glycosylation machinery, resulting in aberrant glycosylation patterns. Traditionally, unique glycocode readers, carbohydrate-binding proteins, have been used to identify differentially expressed carbohydrate determinants associated with the tumor cell surface. However, identifying novel distinctive glycosylation signatures in brain tumors requires the timely development of molecular tools capable of targeting them. We classified marine-derived lectins and lectin-like molecules according to their ability to cover aberrant glycosylation patterns in brain tumors to encourage exploration of the potential of these molecules for precision diagnostics and personalized therapy. |
| format | Article |
| id | doaj-art-bc5a1fe909ca43c3be3af87f797602d6 |
| institution | Kabale University |
| issn | 1660-3397 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Marine Drugs |
| spelling | doaj-art-bc5a1fe909ca43c3be3af87f797602d62024-12-27T14:37:33ZengMDPI AGMarine Drugs1660-33972024-11-01221252710.3390/md22120527Marine Lectins and Lectin-like Proteins as Promising Molecules Targeting Aberrant Glycosylation Signatures in Human Brain TumorsIvan Buriak0Vadim Kumeiko1School of Medicine and Life Sciences, Far Eastern Federal University, 690922 Vladivostok, RussiaSchool of Medicine and Life Sciences, Far Eastern Federal University, 690922 Vladivostok, RussiaGlycosylation is a ubiquitous and the most structurally diverse post-translational modification of proteins. High levels of phenotypic heterogeneity in brain tumors affect the biosynthetic pathway of glycosylation machinery, resulting in aberrant glycosylation patterns. Traditionally, unique glycocode readers, carbohydrate-binding proteins, have been used to identify differentially expressed carbohydrate determinants associated with the tumor cell surface. However, identifying novel distinctive glycosylation signatures in brain tumors requires the timely development of molecular tools capable of targeting them. We classified marine-derived lectins and lectin-like molecules according to their ability to cover aberrant glycosylation patterns in brain tumors to encourage exploration of the potential of these molecules for precision diagnostics and personalized therapy.https://www.mdpi.com/1660-3397/22/12/527bivalvecancergliomadiagnosticslectinC1qDC |
| spellingShingle | Ivan Buriak Vadim Kumeiko Marine Lectins and Lectin-like Proteins as Promising Molecules Targeting Aberrant Glycosylation Signatures in Human Brain Tumors Marine Drugs bivalve cancer glioma diagnostics lectin C1qDC |
| title | Marine Lectins and Lectin-like Proteins as Promising Molecules Targeting Aberrant Glycosylation Signatures in Human Brain Tumors |
| title_full | Marine Lectins and Lectin-like Proteins as Promising Molecules Targeting Aberrant Glycosylation Signatures in Human Brain Tumors |
| title_fullStr | Marine Lectins and Lectin-like Proteins as Promising Molecules Targeting Aberrant Glycosylation Signatures in Human Brain Tumors |
| title_full_unstemmed | Marine Lectins and Lectin-like Proteins as Promising Molecules Targeting Aberrant Glycosylation Signatures in Human Brain Tumors |
| title_short | Marine Lectins and Lectin-like Proteins as Promising Molecules Targeting Aberrant Glycosylation Signatures in Human Brain Tumors |
| title_sort | marine lectins and lectin like proteins as promising molecules targeting aberrant glycosylation signatures in human brain tumors |
| topic | bivalve cancer glioma diagnostics lectin C1qDC |
| url | https://www.mdpi.com/1660-3397/22/12/527 |
| work_keys_str_mv | AT ivanburiak marinelectinsandlectinlikeproteinsaspromisingmoleculestargetingaberrantglycosylationsignaturesinhumanbraintumors AT vadimkumeiko marinelectinsandlectinlikeproteinsaspromisingmoleculestargetingaberrantglycosylationsignaturesinhumanbraintumors |