Histopathological Evaluation of Benign Prostate Lesions - Utility or Futility? A Retrospective Study in a Limited Resource Setting
Objective: To identify the characteristic morphological features of benign prostate lesions, chiefly the mimickers of carcinoma, and to distinguish them from malignancy. Materials and Methods: All prostate specimens diagnosed as benign lesions during the two-year period from January 2022 to December...
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| Language: | English |
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Light House Polyclinic Mangalore
2024-10-01
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| Series: | Online Journal of Health & Allied Sciences |
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| Online Access: | https://www.ojhas.org/issue91/2024-3-4.html |
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| author | Barbie Mech Deepa Hatwal Srijan Srivastav Pawan Bhat |
| author_facet | Barbie Mech Deepa Hatwal Srijan Srivastav Pawan Bhat |
| author_sort | Barbie Mech |
| collection | DOAJ |
| description | Objective: To identify the characteristic morphological features of benign prostate lesions, chiefly the mimickers of carcinoma, and to distinguish them from malignancy. Materials and Methods: All prostate specimens diagnosed as benign lesions during the two-year period from January 2022 to December 2023 were included. Malignant prostate lesions and autolyzed specimens were excluded. Haematoxylin and eosin-stained tissue sections were examined, and their medical records were reviewed. Results: A total of 173 prostate specimens were studied. The most common alteration was Basal cell hyperplasia, and the least common was Nephrogenic metaplasia. For comparison, the lesions were broadly classified into five categories: hyperplasia, atrophy, metaplasia, inflammation, and premalignant lesions. Conclusion: Various prostatic atrophy patterns, metaplasias, and hyperplasias mimic prostatic adenocarcinoma. Transitional cell metaplasia and basal cell hyperplasia mimic HGPIN. HGPIN mimics and leads to carcinoma. Hence, it is important to identify them correctly and prevent any false positive interpretation. |
| format | Article |
| id | doaj-art-bc4fca9a009345f68ea6e904dfe937ad |
| institution | Kabale University |
| issn | 0972-5997 |
| language | English |
| publishDate | 2024-10-01 |
| publisher | Light House Polyclinic Mangalore |
| record_format | Article |
| series | Online Journal of Health & Allied Sciences |
| spelling | doaj-art-bc4fca9a009345f68ea6e904dfe937ad2024-11-13T14:02:11ZengLight House Polyclinic MangaloreOnline Journal of Health & Allied Sciences0972-59972024-10-01233Histopathological Evaluation of Benign Prostate Lesions - Utility or Futility? A Retrospective Study in a Limited Resource SettingBarbie Mech0Deepa Hatwal1Srijan Srivastav2Pawan Bhat3Postgraduate Student, Department of Pathology, Veer Chandra Singh Garhwali Government Institute of Medical Sciences and Research, Srinagar, Uttarakhand, IndiaProfessor, Department of Pathology, Veer Chandra Singh Garhwali Government Institute of Medical Sciences and Research, Srinagar, Uttarakhand, IndiaAssistant Professor, Department of Pathology, Veer Chandra Singh Garhwali Government Institute of Medical Sciences and Research, Srinagar, Uttarakhand, IndiaAssociate Professor, Department of Pathology, Veer Chandra Singh Garhwali Government Institute of Medical Sciences and Research, Srinagar, Uttarakhand, IndiaObjective: To identify the characteristic morphological features of benign prostate lesions, chiefly the mimickers of carcinoma, and to distinguish them from malignancy. Materials and Methods: All prostate specimens diagnosed as benign lesions during the two-year period from January 2022 to December 2023 were included. Malignant prostate lesions and autolyzed specimens were excluded. Haematoxylin and eosin-stained tissue sections were examined, and their medical records were reviewed. Results: A total of 173 prostate specimens were studied. The most common alteration was Basal cell hyperplasia, and the least common was Nephrogenic metaplasia. For comparison, the lesions were broadly classified into five categories: hyperplasia, atrophy, metaplasia, inflammation, and premalignant lesions. Conclusion: Various prostatic atrophy patterns, metaplasias, and hyperplasias mimic prostatic adenocarcinoma. Transitional cell metaplasia and basal cell hyperplasia mimic HGPIN. HGPIN mimics and leads to carcinoma. Hence, it is important to identify them correctly and prevent any false positive interpretation.https://www.ojhas.org/issue91/2024-3-4.htmlprostatebenigncarcinomamimickers |
| spellingShingle | Barbie Mech Deepa Hatwal Srijan Srivastav Pawan Bhat Histopathological Evaluation of Benign Prostate Lesions - Utility or Futility? A Retrospective Study in a Limited Resource Setting Online Journal of Health & Allied Sciences prostate benign carcinoma mimickers |
| title | Histopathological Evaluation of Benign Prostate Lesions - Utility or Futility? A Retrospective Study in a Limited Resource Setting |
| title_full | Histopathological Evaluation of Benign Prostate Lesions - Utility or Futility? A Retrospective Study in a Limited Resource Setting |
| title_fullStr | Histopathological Evaluation of Benign Prostate Lesions - Utility or Futility? A Retrospective Study in a Limited Resource Setting |
| title_full_unstemmed | Histopathological Evaluation of Benign Prostate Lesions - Utility or Futility? A Retrospective Study in a Limited Resource Setting |
| title_short | Histopathological Evaluation of Benign Prostate Lesions - Utility or Futility? A Retrospective Study in a Limited Resource Setting |
| title_sort | histopathological evaluation of benign prostate lesions utility or futility a retrospective study in a limited resource setting |
| topic | prostate benign carcinoma mimickers |
| url | https://www.ojhas.org/issue91/2024-3-4.html |
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