Mechanism-based myofilament manipulation to treat diastolic dysfunction in HFpEF

Mechanism-based myofilament manipulation to treat diastolic dysfunction in HFpEF

Heart failure with preserved ejection fraction (HFpEF) is a major public health challenge, affecting millions worldwide and placing a significant burden on healthcare systems due to high hospitalization rates and limited treatment options. HFpEF is characterized by impaired cardiac relaxation, or di...

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Bibliographic Details
Main Authors:	Katherine L. Dominic, Alexandra V. Schmidt, Henk Granzier, Kenneth S. Campbell, Julian E. Stelzer
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2024-12-01
Series:	Frontiers in Physiology
Subjects:	HFpEF heart failure with preserved ejection fraction cMyBP-C cTnI cardiac troponin I titin
Online Access:	https://www.frontiersin.org/articles/10.3389/fphys.2024.1512550/full
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