MST1, a novel therapeutic target for Alzheimer's disease, regulates mitochondrial homeostasis by mediating mitochondrial DNA transcription and the PI3K-Akt-ROS pathway

MST1, a novel therapeutic target for Alzheimer's disease, regulates mitochondrial homeostasis by mediating mitochondrial DNA transcription and the PI3K-Akt-ROS pathway

Abstract Background Alzheimer's disease (AD) is a prevalent irreversible neurodegenerative condition marked by gradual cognitive deterioration and neuronal loss. The mammalian Ste20-like kinase (MST1)–Hippo pathway is pivotal in regulating cell apoptosis, immune response, mitochondrial function...

Full description

Saved in:

Bibliographic Details
Main Authors:	Dongqing Cui, Haixia Liu, Lili Cao, Xiaowei Du, Dingxin Liu, Zhiping Liu, Tong Wang, Hui Yang, Xiaolei Zheng, Zhaohong Xie, Shunliang Xu, Jianzhong Bi, Ping Wang
Format:	Article
Language:	English
Published:	BMC 2024-11-01
Series:	Journal of Translational Medicine
Subjects:	MST1 Alzheimer’s disease Mitochondrial homeostasis Oxidative phosphorylation (OXPHOS) PI3K-Akt signaling pathway
Online Access:	https://doi.org/10.1186/s12967-024-05852-x
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

Interdisciplinaridade e solidariedade em experiências cooperativas do MST
by: Alceu Ravanello Ferraro
Published: (2005-01-01)

Targeting mitochondrial metabolism by the mitotoxin bromoxib in leukemia and lymphoma cells
by: Laura Schmitt, et al.
Published: (2024-11-01)

Restriction of mitochondrial oxidation of glutamine or fatty acids enhances intracellular growth of Mycobacterium abscessus in macrophages
by: Ho Won Kim, et al.
Published: (2025-12-01)

MST1 interactomes profiling across cell death in esophageal squamous cell carcinoma
by: Zhang Li, et al.
Published: (2024-12-01)

Genome-wide identification and expression profiling of MST, SUT and SWEET transporters in Dendrobium catenatum
by: Weiwei Fan, et al.
Published: (2024-12-01)

A imagem do MST produzida pela mídia e sua influência sobre a formação discursiva dos discentes de uma Universidade Federal
by: Yuri Gomes Figueiredo, et al.
Published: (2018-12-01)

The subcompartmented oxphosomic model of the phosphorylating system organization in mitochondria
by: I. V. Ukolova
Published: (2021-12-01)

The impact of glucose metabolism on inflammatory processes in sepsis-induced acute lung injury
by: Shilei Cheng, et al.
Published: (2024-12-01)

O Estado no Plano Político Estratégico do MST: breves considerações sobre a aproximação com o executivo do Estado durante o Governo Lula
by: Jetson Lourenço Lopes da Silva
Published: (2021-06-01)

Ocio y procesos educativos en el contexto del movimiento de los trabajadores rurales sin tierra (MST) de la región de ribeirão preto – sp – Brasil (Leisure and educational processes in the context of the movement of rural landless workers (MST) in the re
by: Robson Amaral de Silva, et al.
Published: (2020-07-01)

NCAPD3‐mediated AKT activation regulates prostate cancer progression
by: Yi Zhang, et al.
Published: (2025-02-01)

Exerkines and Sarcopenia: Unveiling the Mechanism Behind Exercise-Induced Mitochondrial Homeostasis
by: Jiayin Wang, et al.
Published: (2025-01-01)

SIRT3 Inhibits Cell Proliferation of Nonsmall Cell Lung Carcinoma by Inducing ROS Production
by: Ze Yu, et al.
Published: (2024-11-01)

ANO7 expression in the prostate modulates mitochondrial function and lipid metabolism
by: Christoffer Löf, et al.
Published: (2025-02-01)

Peroxiredoxin 6 maintains mitochondrial homeostasis and promotes tumor progression through ROS/JNK/p38 MAPK signaling pathway in multiple myeloma
by: Dandan Gao, et al.
Published: (2025-01-01)

Tubular MYDGF Slows Progression of Chronic Kidney Disease by Maintaining Mitochondrial Homeostasis
by: Xiaohan Liu, et al.
Published: (2025-01-01)

Decrecimiento y agroecología: La experiencia del Movimiento de Trabajadores Rurales Sin Tierra (MST) en campamentos y asentamientos rurales en el Gran São Paulo, Brasil
by: Aico Nogueira, et al.

AKT1-Mediated NOTCH1 phosphorylation promotes gastric cancer progression via targeted regulation of IRS-1 transcription
by: Lingshan Zhou, et al.
Published: (2024-12-01)

RETRACTED ARTICLE: LRPPRC regulates malignant behaviors, protects mitochondrial homeostasis, mitochondrial function in osteosarcoma and derived cancer stem-like cells
by: Ziyi Zhao, et al.
Published: (2023-10-01)

Dual inhibition of AKT‐mTOR and AR signaling by targeting HDAC3 in PTEN‐ or SPOP‐mutated prostate cancer
by: Yuqian Yan, et al.
Published: (2018-03-01)

The Switching of the Type of a ROS Signal from Mitochondria: The Role of Respiratory Substrates and Permeability Transition
by: Alexey G. Kruglov, et al.
Published: (2024-10-01)

ROS-induced cytosolic release of mitochondrial PGAM5 promotes colorectal cancer progression by interacting with MST3
by: Shiyang Wang, et al.
Published: (2025-02-01)

TBL2 Promotes Tumorigenesis via PRMT5/WDR77‐Mediated AKT Activation in Breast Cancer
by: Xiuqing Lu, et al.
Published: (2024-12-01)

Notoginsenoside R1 Attenuates H/R Injury in H9c2 Cells by Maintaining Mitochondrial Homeostasis
by: Yuanbo Xu, et al.
Published: (2025-01-01)

Protective effect of compound K against podocyte injury in chronic kidney disease by maintaining mitochondrial homeostasis
by: Fugang Huang, et al.
Published: (2025-01-01)

USP26 Combats Age‐Related Declines in Self‐Renewal and Multipotent Differentiation of BMSC by Maintaining Mitochondrial Homeostasis
by: Yiming Xu, et al.
Published: (2024-11-01)

Mitochondrial Dysfunction: Effects and Therapeutic Implications in Cerebral Gliomas
by: Gerardo Caruso, et al.
Published: (2024-11-01)

Metabolic plasticity in pancreatic cancer: The mitochondrial connection
by: Noemi Ghiglione, et al.
Published: (2025-02-01)

Molecular Insights in the Anticancer Activity of Natural Tocotrienols: Targeting Mitochondrial Metabolism and Cellular Redox Homeostasis
by: Raffaella Chiaramonte, et al.
Published: (2025-01-01)

Mammalian Ste-20-like Kinase 1/2 (MST1/2) Inhibitor XMU-MP-1: A Potential Compound to Improve Spermatogenesis in Mouse Model of Diabetes Mellitus
by: Bella Amanda, et al.
Published: (2024-11-01)

Dexmedetomidine alleviates intestinal ischemia/reperfusion injury by modulating intestinal neuron autophagy and mitochondrial homeostasis via Nupr1 regulation
by: Qiong Wu, et al.
Published: (2024-11-01)

Therapies for Mitochondrial Disorders
by: Kayli Sousa Smyth, et al.
Published: (2022-12-01)

Territórios sob tensão: disputas por recursos naturais na reserva legal em bloco do assentamento Margarida Alves, Rondônia
by: Marcelo Pires Negrão, et al.
Published: (2020-05-01)

Autophagy-lysosome pathway in insulin & glucagon homeostasis
by: Yi Wu, et al.
Published: (2025-02-01)

Assessment of mitochondrial function and its prognostic role in sepsis: a literature review
by: Wagner Nedel, et al.
Published: (2024-11-01)

Mitochondria-targeted antioxidant mitoquinone mitigates vitrification-induced damage in mouse ovarian tissue by maintaining mitochondrial homeostasis via the p38 MAPK pathway
by: Tianqi Du, et al.
Published: (2024-12-01)

Differential gene expression analysis supports dysregulation of mitochondrial activity as a new perspective for glioblastoma's aggressiveness
by: Ricardo Cunha de Oliveira, et al.
Published: (2024-11-01)

Enhanced Oxidative Phosphorylation Driven by TACO1 Mitochondrial Translocation Promotes Stemness and Cisplatin Resistance in Bladder Cancer
by: Minhua Deng, et al.
Published: (2025-02-01)

Mitochondrial abnormalities as a target of intervention in acute myeloid leukemia
by: Elissa Tjahjono, et al.
Published: (2025-01-01)

Tetrandrine induces muscle atrophy involving ROS-mediated inhibition of Akt and FoxO3
by: Xin-qi Shan, et al.
Published: (2024-11-01)