MST1, a novel therapeutic target for Alzheimer's disease, regulates mitochondrial homeostasis by mediating mitochondrial DNA transcription and the PI3K-Akt-ROS pathway

MST1, a novel therapeutic target for Alzheimer's disease, regulates mitochondrial homeostasis by mediating mitochondrial DNA transcription and the PI3K-Akt-ROS pathway

Abstract Background Alzheimer's disease (AD) is a prevalent irreversible neurodegenerative condition marked by gradual cognitive deterioration and neuronal loss. The mammalian Ste20-like kinase (MST1)–Hippo pathway is pivotal in regulating cell apoptosis, immune response, mitochondrial function...

Full description

Saved in:
Bibliographic Details
Main Authors: Dongqing Cui, Haixia Liu, Lili Cao, Xiaowei Du, Dingxin Liu, Zhiping Liu, Tong Wang, Hui Yang, Xiaolei Zheng, Zhaohong Xie, Shunliang Xu, Jianzhong Bi, Ping Wang
Format: Article
Language:English
Published: BMC 2024-11-01
Series:Journal of Translational Medicine
Subjects:
MST1
Alzheimer’s disease
Mitochondrial homeostasis
Oxidative phosphorylation (OXPHOS)
PI3K-Akt signaling pathway
Online Access:https://doi.org/10.1186/s12967-024-05852-x
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

https://doi.org/10.1186/s12967-024-05852-x

Similar Items