Chitooligosaccharides promote diabetic wound healing by mediating fibroblast proliferation and migration
Abstract Diabetic wounds are notoriously difficult to heal due to impaired cell repair mechanisms, reduced angiogenesis, and a heightened risk of infection. Fibroblasts play a vital role in wound healing by producing extracellular matrix (ECM) components and various growth factors, but their functio...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2025-01-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-024-84398-w |
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| author | Zihan Li Chuwei Zhang Lei Wang Qingrong Zhang Yipeng Dong Xinyu Sha Bolin Wang Zhihan Zhu Wenmiao Wang Yongjun Wang Youlang Zhou Yi Zhang |
| author_facet | Zihan Li Chuwei Zhang Lei Wang Qingrong Zhang Yipeng Dong Xinyu Sha Bolin Wang Zhihan Zhu Wenmiao Wang Yongjun Wang Youlang Zhou Yi Zhang |
| author_sort | Zihan Li |
| collection | DOAJ |
| description | Abstract Diabetic wounds are notoriously difficult to heal due to impaired cell repair mechanisms, reduced angiogenesis, and a heightened risk of infection. Fibroblasts play a vital role in wound healing by producing extracellular matrix (ECM) components and various growth factors, but their function is inhibited in diabetic wounds. Chitooligosaccharides (COS), intermediate products of chitosan degradation, have shown efficacy in promoting tissue repair, yet their role in diabetic wound healing remains underexplored. In a mouse model of diabetic wounds, COS treatment demonstrated substantial bioactivity in accelerating wound healing by enhancing fibroblast proliferation and migration. Additionally, COS increased collagen III deposition and angiogenesis at the wound sites. The COS also mitigated inflammatory responses by controlling leukocyte infiltration and bacterial infection. Mechanistically, COS regulated fibroblast activity via the PI3K/Akt signaling pathway, providing a novel bioactive material for chronic wound healing. |
| format | Article |
| id | doaj-art-bc2e90670fd14d77be75864ea1dbc838 |
| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj-art-bc2e90670fd14d77be75864ea1dbc8382025-01-05T12:18:00ZengNature PortfolioScientific Reports2045-23222025-01-0115111510.1038/s41598-024-84398-wChitooligosaccharides promote diabetic wound healing by mediating fibroblast proliferation and migrationZihan Li0Chuwei Zhang1Lei Wang2Qingrong Zhang3Yipeng Dong4Xinyu Sha5Bolin Wang6Zhihan Zhu7Wenmiao Wang8Yongjun Wang9Youlang Zhou10Yi Zhang11Department of Burn and Plastic Surgery, Affiliated Hospital of Nantong UniversityDepartment of Burn and Plastic Surgery, Affiliated Hospital of Nantong UniversityDepartment of Burn and Plastic Surgery, Affiliated Hospital of Nantong UniversityDepartment of Burn and Plastic Surgery, Affiliated Hospital of Nantong UniversityShanghai Children’s Medical Center, Shanghai Jiao Tong University School of MedicineAffiliated Hospital of Jiangnan UniversityDepartment of Burn and Plastic Surgery, Affiliated Hospital of Nantong UniversityDepartment of Burn and Plastic Surgery, Affiliated Hospital of Nantong UniversityShandong UniversityKey Laboratory of Neuroregeneration of Jiangsu and Ministry of Education, Co-Innovation Center of Neuroregeneration, Nantong UniversityDepartment of Burn and Plastic Surgery, Affiliated Hospital of Nantong UniversityDepartment of Burn and Plastic Surgery, Affiliated Hospital of Nantong UniversityAbstract Diabetic wounds are notoriously difficult to heal due to impaired cell repair mechanisms, reduced angiogenesis, and a heightened risk of infection. Fibroblasts play a vital role in wound healing by producing extracellular matrix (ECM) components and various growth factors, but their function is inhibited in diabetic wounds. Chitooligosaccharides (COS), intermediate products of chitosan degradation, have shown efficacy in promoting tissue repair, yet their role in diabetic wound healing remains underexplored. In a mouse model of diabetic wounds, COS treatment demonstrated substantial bioactivity in accelerating wound healing by enhancing fibroblast proliferation and migration. Additionally, COS increased collagen III deposition and angiogenesis at the wound sites. The COS also mitigated inflammatory responses by controlling leukocyte infiltration and bacterial infection. Mechanistically, COS regulated fibroblast activity via the PI3K/Akt signaling pathway, providing a novel bioactive material for chronic wound healing.https://doi.org/10.1038/s41598-024-84398-w |
| spellingShingle | Zihan Li Chuwei Zhang Lei Wang Qingrong Zhang Yipeng Dong Xinyu Sha Bolin Wang Zhihan Zhu Wenmiao Wang Yongjun Wang Youlang Zhou Yi Zhang Chitooligosaccharides promote diabetic wound healing by mediating fibroblast proliferation and migration Scientific Reports |
| title | Chitooligosaccharides promote diabetic wound healing by mediating fibroblast proliferation and migration |
| title_full | Chitooligosaccharides promote diabetic wound healing by mediating fibroblast proliferation and migration |
| title_fullStr | Chitooligosaccharides promote diabetic wound healing by mediating fibroblast proliferation and migration |
| title_full_unstemmed | Chitooligosaccharides promote diabetic wound healing by mediating fibroblast proliferation and migration |
| title_short | Chitooligosaccharides promote diabetic wound healing by mediating fibroblast proliferation and migration |
| title_sort | chitooligosaccharides promote diabetic wound healing by mediating fibroblast proliferation and migration |
| url | https://doi.org/10.1038/s41598-024-84398-w |
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