Targeting EP2 Receptor Improves Muscle and Bone Health in Dystrophin<sup>−/−</sup>/Utrophin<sup>−/−</sup> Double-Knockout Mice

Targeting EP2 Receptor Improves Muscle and Bone Health in Dystrophin<sup>−/−</sup>/Utrophin<sup>−/−</sup> Double-Knockout Mice

Duchenne muscular dystrophy (DMD) is a severe genetic muscle disease occurring due to mutations of the dystrophin gene. There is no cure for DMD. Using a dystrophin<sup>−/−</sup>utrophin<sup>−/−</sup> (DKO-Hom) mouse model, we investigated the PGE2/EP2 pathway in the pathogen...

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Bibliographic Details
Main Authors: Xueqin Gao, Yan Cui, Greg Zhang, Joseph J. Ruzbarsky, Bing Wang, Jonathan E. Layne, Xiang Xiao, Johnny Huard
Format: Article
Language:English
Published: MDPI AG 2025-01-01
Series:Cells
Subjects:
muscular dystrophy
EP2
EP4
PGE2
bone microarchitecture
heterotopic ossification
Online Access:https://www.mdpi.com/2073-4409/14/2/116
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