Evaluating quality of life improvements in endometriosis patients following laparoscopic surgery using EHP-30 scale
Abstract This study aims to evaluate whether laparoscopic surgery enhances health-related quality of life (HRQoL) in endometriosis patients, utilizing the Endometriosis Health Profile-30 (EHP-30) questionnaire. The study also explores the correlations between disease severity, preoperative scores, a...
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Nature Portfolio
2025-01-01
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| Online Access: | https://doi.org/10.1038/s41598-024-84370-8 |
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| author | Yuyan Guo Penghui Huang Chaobin Liu Zhenna Wang Yi Wang Wei Qi Xi Xie Zhenhong Wang Jinna Zhang Shunhe Lin |
| author_facet | Yuyan Guo Penghui Huang Chaobin Liu Zhenna Wang Yi Wang Wei Qi Xi Xie Zhenhong Wang Jinna Zhang Shunhe Lin |
| author_sort | Yuyan Guo |
| collection | DOAJ |
| description | Abstract This study aims to evaluate whether laparoscopic surgery enhances health-related quality of life (HRQoL) in endometriosis patients, utilizing the Endometriosis Health Profile-30 (EHP-30) questionnaire. The study also explores the correlations between disease severity, preoperative scores, and the subsequent changes following surgical intervention. This is a prospective observational study. Seventy women undergoing laparoscopic surgery for endometriosis at Fujian Maternity and Child Health Hospital were prospectively recruited. Each participant was assessed using the EHP-30 questionnaire both 4 weeks prior to and 3 months post-surgery to obtain preoperative and postoperative subscale scores. The Wilcoxon signed-rank test was applied to determine the statistical significance of changes in these scores. Spearman’s rank correlation coefficient was employed to explore the relationships between preoperative EHP-30 scores, serum CA125 levels, and intraoperative revised American Society for Reproductive Medicine (rASRM) scores. Statistically significant correlations were further examined using multivariate linear regression analysis to adjust for potential confounders. Laparoscopic surgery resulted in a significant reduction in EHP-30 subscale scores (P ≤ 0.002), indicating a marked improvement in HRQoL among endometriosis patients. Spearman correlation analysis revealed positive correlations between preoperative serum CA125 levels (P = 0.005) and intraoperative rASRM scores with preoperative pain (P = 0.035) and sexual intercourse scores (P = 0.046). Additionally, multivariate linear regression analyses demonstrated that changes in pain scores (ΔPain), control and powerlessness (ΔControl and Powerlessness), and work life (ΔWork Life) were significantly interrelated (P < 0.01). Emotional well-being (ΔEmotional Well-being), control and powerlessness (ΔControl and Powerlessness), and work life (ΔWork Life) also exhibited significant mutual influences (P < 0.01). Furthermore, changes in social support (ΔSocial Support), self-image (ΔSelf-image), and treatment perception (ΔTreatment) were positively correlated (P < 0.01), as were changes in sexual intercourse (ΔSexual Intercourse) and concern about infertility (ΔConcern on Infertility) (P < 0.01). Laparoscopic surgery for endometriosis significantly improves HRQoL by alleviating pain and positively influencing daily functioning and emotional well-being. These findings highlight the critical role of laparoscopic surgery as an effective intervention for enhancing the quality of life in endometriosis patients. |
| format | Article |
| id | doaj-art-bc101ffcab744ab99972d9452a2c4fc0 |
| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-01-01 |
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| spelling | doaj-art-bc101ffcab744ab99972d9452a2c4fc02025-01-12T12:23:28ZengNature PortfolioScientific Reports2045-23222025-01-0115111010.1038/s41598-024-84370-8Evaluating quality of life improvements in endometriosis patients following laparoscopic surgery using EHP-30 scaleYuyan Guo0Penghui Huang1Chaobin Liu2Zhenna Wang3Yi Wang4Wei Qi5Xi Xie6Zhenhong Wang7Jinna Zhang8Shunhe Lin9Department of Physical Examination Center, Fujian Medical University Union HospitalFujian Maternity and Child Health Hospital, College of Clinical Medicine for Obstetrics and Gynecology and Pediatrics, Fujian Medical UniversityFujian Maternity and Child Health Hospital, College of Clinical Medicine for Obstetrics and Gynecology and Pediatrics, Fujian Medical UniversityFujian Maternity and Child Health Hospital, College of Clinical Medicine for Obstetrics and Gynecology and Pediatrics, Fujian Medical UniversityFujian Maternity and Child Health Hospital, College of Clinical Medicine for Obstetrics and Gynecology and Pediatrics, Fujian Medical UniversityFujian Maternity and Child Health Hospital, College of Clinical Medicine for Obstetrics and Gynecology and Pediatrics, Fujian Medical UniversityFujian Maternity and Child Health Hospital, College of Clinical Medicine for Obstetrics and Gynecology and Pediatrics, Fujian Medical UniversityFujian Maternity and Child Health Hospital, College of Clinical Medicine for Obstetrics and Gynecology and Pediatrics, Fujian Medical UniversityFujian Maternity and Child Health Hospital, College of Clinical Medicine for Obstetrics and Gynecology and Pediatrics, Fujian Medical UniversityFujian Maternity and Child Health Hospital, College of Clinical Medicine for Obstetrics and Gynecology and Pediatrics, Fujian Medical UniversityAbstract This study aims to evaluate whether laparoscopic surgery enhances health-related quality of life (HRQoL) in endometriosis patients, utilizing the Endometriosis Health Profile-30 (EHP-30) questionnaire. The study also explores the correlations between disease severity, preoperative scores, and the subsequent changes following surgical intervention. This is a prospective observational study. Seventy women undergoing laparoscopic surgery for endometriosis at Fujian Maternity and Child Health Hospital were prospectively recruited. Each participant was assessed using the EHP-30 questionnaire both 4 weeks prior to and 3 months post-surgery to obtain preoperative and postoperative subscale scores. The Wilcoxon signed-rank test was applied to determine the statistical significance of changes in these scores. Spearman’s rank correlation coefficient was employed to explore the relationships between preoperative EHP-30 scores, serum CA125 levels, and intraoperative revised American Society for Reproductive Medicine (rASRM) scores. Statistically significant correlations were further examined using multivariate linear regression analysis to adjust for potential confounders. Laparoscopic surgery resulted in a significant reduction in EHP-30 subscale scores (P ≤ 0.002), indicating a marked improvement in HRQoL among endometriosis patients. Spearman correlation analysis revealed positive correlations between preoperative serum CA125 levels (P = 0.005) and intraoperative rASRM scores with preoperative pain (P = 0.035) and sexual intercourse scores (P = 0.046). Additionally, multivariate linear regression analyses demonstrated that changes in pain scores (ΔPain), control and powerlessness (ΔControl and Powerlessness), and work life (ΔWork Life) were significantly interrelated (P < 0.01). Emotional well-being (ΔEmotional Well-being), control and powerlessness (ΔControl and Powerlessness), and work life (ΔWork Life) also exhibited significant mutual influences (P < 0.01). Furthermore, changes in social support (ΔSocial Support), self-image (ΔSelf-image), and treatment perception (ΔTreatment) were positively correlated (P < 0.01), as were changes in sexual intercourse (ΔSexual Intercourse) and concern about infertility (ΔConcern on Infertility) (P < 0.01). Laparoscopic surgery for endometriosis significantly improves HRQoL by alleviating pain and positively influencing daily functioning and emotional well-being. These findings highlight the critical role of laparoscopic surgery as an effective intervention for enhancing the quality of life in endometriosis patients.https://doi.org/10.1038/s41598-024-84370-8EndometriosisLaparoscopic surgeryHealth-related quality of life (HRQoL)Endometriosis Health Profile-30 (EHP-30)Serum CA125rASRM scores |
| spellingShingle | Yuyan Guo Penghui Huang Chaobin Liu Zhenna Wang Yi Wang Wei Qi Xi Xie Zhenhong Wang Jinna Zhang Shunhe Lin Evaluating quality of life improvements in endometriosis patients following laparoscopic surgery using EHP-30 scale Scientific Reports Endometriosis Laparoscopic surgery Health-related quality of life (HRQoL) Endometriosis Health Profile-30 (EHP-30) Serum CA125 rASRM scores |
| title | Evaluating quality of life improvements in endometriosis patients following laparoscopic surgery using EHP-30 scale |
| title_full | Evaluating quality of life improvements in endometriosis patients following laparoscopic surgery using EHP-30 scale |
| title_fullStr | Evaluating quality of life improvements in endometriosis patients following laparoscopic surgery using EHP-30 scale |
| title_full_unstemmed | Evaluating quality of life improvements in endometriosis patients following laparoscopic surgery using EHP-30 scale |
| title_short | Evaluating quality of life improvements in endometriosis patients following laparoscopic surgery using EHP-30 scale |
| title_sort | evaluating quality of life improvements in endometriosis patients following laparoscopic surgery using ehp 30 scale |
| topic | Endometriosis Laparoscopic surgery Health-related quality of life (HRQoL) Endometriosis Health Profile-30 (EHP-30) Serum CA125 rASRM scores |
| url | https://doi.org/10.1038/s41598-024-84370-8 |
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