FAM20C: A key protein kinase in multiple diseases
Family with sequence similarity 20 C (FAM20C) is a Golgi protein kinase that phosphorylates the serine residue in the S-x-E/pS motif of target proteins. FAM20C phosphorylates most secreted proteins, which play important roles in multiple biological processes, including cancer progression, biomineral...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
KeAi Communications Co., Ltd.
2025-03-01
|
| Series: | Genes and Diseases |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2352304223004622 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1846107734898900992 |
|---|---|
| author | Rui Zhang Yanming Ren Yan Ju Yuekang Zhang Yan Zhang Yuan Wang |
| author_facet | Rui Zhang Yanming Ren Yan Ju Yuekang Zhang Yan Zhang Yuan Wang |
| author_sort | Rui Zhang |
| collection | DOAJ |
| description | Family with sequence similarity 20 C (FAM20C) is a Golgi protein kinase that phosphorylates the serine residue in the S-x-E/pS motif of target proteins. FAM20C phosphorylates most secreted proteins, which play important roles in multiple biological processes, including cancer progression, biomineralization, and lipid homeostasis. Numerous studies have documented the potential contribution of FAM20C to the growth, invasion, and metastasis of glioma, breast cancer, and other cancers, as well as to the mineralization process of teeth and bone. In addition, FAM20C has been found to be associated with the occurrence and development of certain cardiovascular diseases and endocrine metabolism disorders. It raises hopes that understanding the disease-specific mechanisms of FAM20C may hold the key to developing new strategies for these diseases. This review comprehensively covers the existing literature to provide a summary of the structure and biological functions of FAM20C, with a particular focus on its roles in the disease context. |
| format | Article |
| id | doaj-art-bc04c2a50863445f8dbe963415bd3ed9 |
| institution | Kabale University |
| issn | 2352-3042 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | KeAi Communications Co., Ltd. |
| record_format | Article |
| series | Genes and Diseases |
| spelling | doaj-art-bc04c2a50863445f8dbe963415bd3ed92024-12-26T08:56:22ZengKeAi Communications Co., Ltd.Genes and Diseases2352-30422025-03-01122101179FAM20C: A key protein kinase in multiple diseasesRui Zhang0Yanming Ren1Yan Ju2Yuekang Zhang3Yan Zhang4Yuan Wang5Department of Neurosurgery, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, ChinaDepartment of Neurosurgery, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, ChinaDepartment of Neurosurgery, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, ChinaDepartment of Neurosurgery, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, ChinaNational Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China; Corresponding author.Department of Neurosurgery, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China; Corresponding author.Family with sequence similarity 20 C (FAM20C) is a Golgi protein kinase that phosphorylates the serine residue in the S-x-E/pS motif of target proteins. FAM20C phosphorylates most secreted proteins, which play important roles in multiple biological processes, including cancer progression, biomineralization, and lipid homeostasis. Numerous studies have documented the potential contribution of FAM20C to the growth, invasion, and metastasis of glioma, breast cancer, and other cancers, as well as to the mineralization process of teeth and bone. In addition, FAM20C has been found to be associated with the occurrence and development of certain cardiovascular diseases and endocrine metabolism disorders. It raises hopes that understanding the disease-specific mechanisms of FAM20C may hold the key to developing new strategies for these diseases. This review comprehensively covers the existing literature to provide a summary of the structure and biological functions of FAM20C, with a particular focus on its roles in the disease context.http://www.sciencedirect.com/science/article/pii/S2352304223004622Biological functionsBiomineralizationCancer progressionFAM20CProtein phosphorylation |
| spellingShingle | Rui Zhang Yanming Ren Yan Ju Yuekang Zhang Yan Zhang Yuan Wang FAM20C: A key protein kinase in multiple diseases Genes and Diseases Biological functions Biomineralization Cancer progression FAM20C Protein phosphorylation |
| title | FAM20C: A key protein kinase in multiple diseases |
| title_full | FAM20C: A key protein kinase in multiple diseases |
| title_fullStr | FAM20C: A key protein kinase in multiple diseases |
| title_full_unstemmed | FAM20C: A key protein kinase in multiple diseases |
| title_short | FAM20C: A key protein kinase in multiple diseases |
| title_sort | fam20c a key protein kinase in multiple diseases |
| topic | Biological functions Biomineralization Cancer progression FAM20C Protein phosphorylation |
| url | http://www.sciencedirect.com/science/article/pii/S2352304223004622 |
| work_keys_str_mv | AT ruizhang fam20cakeyproteinkinaseinmultiplediseases AT yanmingren fam20cakeyproteinkinaseinmultiplediseases AT yanju fam20cakeyproteinkinaseinmultiplediseases AT yuekangzhang fam20cakeyproteinkinaseinmultiplediseases AT yanzhang fam20cakeyproteinkinaseinmultiplediseases AT yuanwang fam20cakeyproteinkinaseinmultiplediseases |