Mucosal SARS-CoV-2 S1 adenovirus-based vaccine elicits robust systemic and mucosal immunity and protects against disease in animals

Mucosal SARS-CoV-2 S1 adenovirus-based vaccine elicits robust systemic and mucosal immunity and protects against disease in animals

ABSTRACT The COVID-19 pandemic has emphasized the importance and need for accessible safe, effective, and versatile vaccine platforms. While approved SARS-CoV-2 vaccines have been instrumental in saving lives and reducing healthcare and economic burdens, the induction of mucosal immunity remains an...

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Main Authors: Najwa D. Aljehani, Levi Tamming, Muhammad Yasir Khan, Rwaa H. Abdulal, Mohamed A. Alfaleh, Aishah Ghazwani, Asalah Helal, Reem M. Alsulaiman, Mohammad A. Sanki, Khalid Alluhaybi, Farah Ayman Sukareh, Rahaf H. Alharbi, Faris H. Alyami, M-Zaki ElAssouli, Salima Shebbo, Wesam H. Abdulaal, Abdullah Algaissi, Ahmad Bakur Mahmoud, Mohammad Basabrain, Diana Duque, Jegarubee Bavananthasivam, Wangxue Chen, Lisheng Wang, Simon Sauve, Turki S. Abujamel, Tarfa Altorki, Rowa Alhabbab, Anh Tran, Xuguang Li, Anwar M. Hashem
Format: Article
Language:English
Published: American Society for Microbiology 2025-01-01
Series:mBio
Subjects:
vaccine
SARS-CoV-2
mucosal vaccines
adenoviruses
Online Access:https://journals.asm.org/doi/10.1128/mbio.02170-24
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