CAR-T cell therapy: developments, challenges and expanded applications from cancer to autoimmunity

CAR-T cell therapy: developments, challenges and expanded applications from cancer to autoimmunity

Chimeric Antigen Receptor (CAR)-T cell therapy has rapidly emerged as a groundbreaking approach in cancer treatment, particularly for hematologic malignancies. However, the application of CAR-T cell therapy in solid tumors remains challenging. This review summarized the development of CAR-T technolo...

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Bibliographic Details
Main Authors: Yaojie Kong, Jingyao Li, Xueyao Zhao, Yanwei Wu, Liang Chen
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-01-01
Series:Frontiers in Immunology
Subjects:
CAR-T cell therapy
solid tumors
autoimmune diseases
dual-CAR strategy
CAR-Treg
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1519671/full
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