Extrachromosomal circular DNA and their roles in cancer progression
Extrachromosomal circular DNA (eccDNA), a chromosome-independent circular DNA, has garnered significant attention due to its widespread distribution and intricate biogenesis in carcinoma. Existing research findings propose that multiple eccDNAs contribute to drug resistance in cancer treatments thro...
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| Format: | Article |
| Language: | English |
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KeAi Communications Co., Ltd.
2025-01-01
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| Series: | Genes and Diseases |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2352304223004853 |
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| author | Siqi Zheng Yunong Li Lin Wang Qian Wei Minjie Wei Tao Yu Lin Zhao |
| author_facet | Siqi Zheng Yunong Li Lin Wang Qian Wei Minjie Wei Tao Yu Lin Zhao |
| author_sort | Siqi Zheng |
| collection | DOAJ |
| description | Extrachromosomal circular DNA (eccDNA), a chromosome-independent circular DNA, has garnered significant attention due to its widespread distribution and intricate biogenesis in carcinoma. Existing research findings propose that multiple eccDNAs contribute to drug resistance in cancer treatments through complex and interrelated regulatory mechanisms. The unique structure and genetic properties of eccDNA increase tumor heterogeneity. This increased diversity is a result of eccDNA's ability to stimulate oncogene remodeling and participate in anomalous splicing processes through chimeric cyclization and the reintegration of loop DNA back into the linear genome. Such actions promote oncogene amplification and silencing. eccDNA orchestrates protein interactions and modulates protein degradation by acting as a regulatory messenger. Moreover, it plays a pivotal role in modeling the tumor microenvironment and intensifying the stemness characteristics of tumor cells. This review presented detailed information about the biogenesis, distinguishing features, and functions of eccDNA, emphasized the role and mechanisms of eccDNA during cancer treatment, and further proposed the great potential of eccDNA in inspiring novel strategies for precision cancer therapy and facilitating the discovery of prognostic biomarkers for cancer. |
| format | Article |
| id | doaj-art-bbc9abfbac054507b74d551e67e0ab1f |
| institution | Kabale University |
| issn | 2352-3042 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | KeAi Communications Co., Ltd. |
| record_format | Article |
| series | Genes and Diseases |
| spelling | doaj-art-bbc9abfbac054507b74d551e67e0ab1f2024-11-13T04:29:48ZengKeAi Communications Co., Ltd.Genes and Diseases2352-30422025-01-01121101202Extrachromosomal circular DNA and their roles in cancer progressionSiqi Zheng0Yunong Li1Lin Wang2Qian Wei3Minjie Wei4Tao Yu5Lin Zhao6Department of Pharmacology, School of Pharmacy, China Liaoning Key Laboratory of Molecular Targeted Anti-Tumor Drug Development and Evaluation, Liaoning Cancer Immune Peptide Drug Engineering Technology Research Center, Key Laboratory of Precision Diagnosis and Treatment of Gastrointestinal Tumors, Ministry of Education, China Medical University, Shenyang, Liaoning 110122, ChinaDepartment of Pharmacology, School of Pharmacy, China Liaoning Key Laboratory of Molecular Targeted Anti-Tumor Drug Development and Evaluation, Liaoning Cancer Immune Peptide Drug Engineering Technology Research Center, Key Laboratory of Precision Diagnosis and Treatment of Gastrointestinal Tumors, Ministry of Education, China Medical University, Shenyang, Liaoning 110122, ChinaDepartment of Pharmacology, School of Pharmacy, China Liaoning Key Laboratory of Molecular Targeted Anti-Tumor Drug Development and Evaluation, Liaoning Cancer Immune Peptide Drug Engineering Technology Research Center, Key Laboratory of Precision Diagnosis and Treatment of Gastrointestinal Tumors, Ministry of Education, China Medical University, Shenyang, Liaoning 110122, ChinaDepartment of Pharmacology, School of Pharmacy, China Liaoning Key Laboratory of Molecular Targeted Anti-Tumor Drug Development and Evaluation, Liaoning Cancer Immune Peptide Drug Engineering Technology Research Center, Key Laboratory of Precision Diagnosis and Treatment of Gastrointestinal Tumors, Ministry of Education, China Medical University, Shenyang, Liaoning 110122, ChinaDepartment of Pharmacology, School of Pharmacy, China Liaoning Key Laboratory of Molecular Targeted Anti-Tumor Drug Development and Evaluation, Liaoning Cancer Immune Peptide Drug Engineering Technology Research Center, Key Laboratory of Precision Diagnosis and Treatment of Gastrointestinal Tumors, Ministry of Education, China Medical University, Shenyang, Liaoning 110122, ChinaDepartment of Medical Imaging, Cancer Hospital of China Medical University, Liaoning Cancer Hospital & Institute, Shenyang, Liaoning 110042, China; Corresponding author. Department of Medical Imaging, Cancer Hospital of China Medical University, Liaoning Cancer Hospital & Institute, No. 44 Xiaoheyan Road, Dadong District, Shenyang, Liaoning 110042, China. Fax: +86 02424315679.Department of Pharmacology, School of Pharmacy, China Liaoning Key Laboratory of Molecular Targeted Anti-Tumor Drug Development and Evaluation, Liaoning Cancer Immune Peptide Drug Engineering Technology Research Center, Key Laboratory of Precision Diagnosis and Treatment of Gastrointestinal Tumors, Ministry of Education, China Medical University, Shenyang, Liaoning 110122, China; Corresponding author. China Medical University, Shenyang, Liaoning 110122, China. Fax: +86 02424315679.Extrachromosomal circular DNA (eccDNA), a chromosome-independent circular DNA, has garnered significant attention due to its widespread distribution and intricate biogenesis in carcinoma. Existing research findings propose that multiple eccDNAs contribute to drug resistance in cancer treatments through complex and interrelated regulatory mechanisms. The unique structure and genetic properties of eccDNA increase tumor heterogeneity. This increased diversity is a result of eccDNA's ability to stimulate oncogene remodeling and participate in anomalous splicing processes through chimeric cyclization and the reintegration of loop DNA back into the linear genome. Such actions promote oncogene amplification and silencing. eccDNA orchestrates protein interactions and modulates protein degradation by acting as a regulatory messenger. Moreover, it plays a pivotal role in modeling the tumor microenvironment and intensifying the stemness characteristics of tumor cells. This review presented detailed information about the biogenesis, distinguishing features, and functions of eccDNA, emphasized the role and mechanisms of eccDNA during cancer treatment, and further proposed the great potential of eccDNA in inspiring novel strategies for precision cancer therapy and facilitating the discovery of prognostic biomarkers for cancer.http://www.sciencedirect.com/science/article/pii/S2352304223004853Alternative splicingCancer stem cellExtrachromosomal circle DNAProtein–protein interactionTumor heterogeneityTumor immune microenvironment |
| spellingShingle | Siqi Zheng Yunong Li Lin Wang Qian Wei Minjie Wei Tao Yu Lin Zhao Extrachromosomal circular DNA and their roles in cancer progression Genes and Diseases Alternative splicing Cancer stem cell Extrachromosomal circle DNA Protein–protein interaction Tumor heterogeneity Tumor immune microenvironment |
| title | Extrachromosomal circular DNA and their roles in cancer progression |
| title_full | Extrachromosomal circular DNA and their roles in cancer progression |
| title_fullStr | Extrachromosomal circular DNA and their roles in cancer progression |
| title_full_unstemmed | Extrachromosomal circular DNA and their roles in cancer progression |
| title_short | Extrachromosomal circular DNA and their roles in cancer progression |
| title_sort | extrachromosomal circular dna and their roles in cancer progression |
| topic | Alternative splicing Cancer stem cell Extrachromosomal circle DNA Protein–protein interaction Tumor heterogeneity Tumor immune microenvironment |
| url | http://www.sciencedirect.com/science/article/pii/S2352304223004853 |
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